KEGG   DRUG: AcetazolamideHelp
Entry
D00218                      Drug                                   

Name
Acetazolamide (JP17/USP/INN);
Diamox (TN)
Product
  Generic
ACETAZOLAMIDE (A-S Medication Solutions), ACETAZOLAMIDE (A-S Medication Solutions), ACETAZOLAMIDE (American Health Packaging), ACETAZOLAMIDE (American Health Packaging), ACETAZOLAMIDE (AvKARE), ACETAZOLAMIDE (AvKARE), ACETAZOLAMIDE (Golden State Medical Supply), ACETAZOLAMIDE (Heritage Pharmaceuticals), ACETAZOLAMIDE (Heritage Pharmaceuticals), ACETAZOLAMIDE (Ingenus Pharmaceuticals), ACETAZOLAMIDE (KAISER FOUNDATION HOSPITALS), ACETAZOLAMIDE (Lannett Company), ACETAZOLAMIDE (Marlex Pharmaceuticals), ACETAZOLAMIDE (NCS HealthCare of KY), ACETAZOLAMIDE (Nostrum Laboratories), ACETAZOLAMIDE (PD-Rx Pharmaceuticals), ACETAZOLAMIDE (PD-Rx Pharmaceuticals), ACETAZOLAMIDE (RedPharm Drug), ACETAZOLAMIDE (Strides Shasun Limited), ACETAZOLAMIDE (Taro Pharmaceuticals U.S.A.), ACETAZOLAMIDE (Teva Pharmaceuticals USA), ACETAZOLAMIDE (Zydus Pharmaceuticals USA)
Formula
C4H6N4O3S2
Exact mass
221.9881
Mol weight
222.2454
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01534  Carbonic anhydrase inhibitor
Remark
Same as: C06805
Therapeutic category: 2134
ATC code: S01EC01
Chemical structure group: DG01134
Product (DG01134): D00218<JP/US> D01196<JP/US>
Efficacy
Antiglaucoma, Carbonic anhydrase inhibitor
  Disease
Chronic simple (open-angle) glaucoma [DS:H00612]
Comment
Sulfonamide derivative
Diuretic action
Target
  Pathway
hsa04964  Proximal tubule bicarbonate reclamation
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07033  Anticonvulsants
map07054  Antiglaucoma agents
map07055  Sulfonamide derivatives - overview
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC01 Acetazolamide
      D00218  Acetazolamide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Carbonic Anhydrase Inhibitors
   Acetazolamide
    D00218  Acetazolamide (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Acetazolamide
    D00218  Acetazolamide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2134  Carbonic anhydrase inhibitors
     D00218  Acetazolamide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA
     D00218  Acetazolamide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00218  Acetazolamide
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00218
BRITE hierarchy
Other DBs
CAS: 59-66-5
PubChem: 7847285
ChEBI: 27690
ChEMBL: CHEMBL20
DrugBank: DB00819
PDB-CCD: AZM[PDBj]
LigandBox: D00218
NIKKAJI: J1.395A
LinkDB All DBs
KCF data Show

ATOM        13
            1   C8y C    19.6602  -17.3655
            2   S2x S    20.7952  -16.5406
            3   N5x N    20.0991  -18.6934
            4   S4a S    18.2620  -17.3595
            5   C8y C    21.9303  -17.3655
            6   N5x N    21.4973  -18.6934
            7   N1a N    18.2503  -18.7579
            8   O3c O    18.2503  -15.9613
            9   O3c O    16.8579  -17.3595
            10  N1b N    23.1354  -16.6517
            11  C5a C    24.3464  -17.3538
            12  C1a C    25.5574  -16.6459
            13  O5a O    24.3464  -18.7519
BOND        13
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     4   9 2
            9     5  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 2
            13    5   6 2

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