ORTHOLOGY: K18245
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Entry
K18245 KO
Symbol
CA2
Name
carbonic anhydrase 2 [EC:
4.2.1.1
]
Pathway
map00910
Nitrogen metabolism
map01100
Metabolic pathways
map04964
Proximal tubule bicarbonate reclamation
map04966
Collecting duct acid secretion
map04971
Gastric acid secretion
map04972
Pancreatic secretion
map04976
Bile secretion
Reaction
R10092
carbonate hydro-lyase (carbon-dioxide-forming)
Disease
H00241
Combined proximal and distal renal tubular acidosis (RTA type 3)
H00436
Osteopetrosis
H02310
Renal tubular acidosis
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09102 Energy metabolism
00910 Nitrogen metabolism
K18245 CA2; carbonic anhydrase 2
09150 Organismal Systems
09154 Digestive system
04971 Gastric acid secretion
K18245 CA2; carbonic anhydrase 2
04972 Pancreatic secretion
K18245 CA2; carbonic anhydrase 2
04976 Bile secretion
K18245 CA2; carbonic anhydrase 2
09155 Excretory system
04964 Proximal tubule bicarbonate reclamation
K18245 CA2; carbonic anhydrase 2
04966 Collecting duct acid secretion
K18245 CA2; carbonic anhydrase 2
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome
K18245 CA2; carbonic anhydrase 2
Enzymes [BR:
ko01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.1 carbonic anhydrase
K18245 CA2; carbonic anhydrase 2
Exosome [BR:
ko04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
K18245 CA2; carbonic anhydrase 2
BRITE hierarchy
Other DBs
GO:
0004089
Genes
HSA:
760
(CA2)
PTR:
450162
(CA2)
PPS:
103782648
(CA2)
GGO:
101130277
(CA2)
PON:
100439372
(CA2)
PPYG:
129042669
(CA2)
NLE:
100597559
(CA2)
HMH:
116813377
(CA2)
SSYN:
129486565
(CA2)
MCC:
574263
(CA2)
MCF:
101866067
(CA2)
MTHB:
126961179
MNI:
105477141
(CA2)
CSAB:
103237071
(CA2)
CATY:
105572895
(CA2)
PANU:
101026583
(CA2)
TGE:
112630001
(CA2)
RRO:
104676872
(CA2)
RBB:
108513910
(CA2)
TFN:
117079528
(CA2)
PTEH:
111553185
(CA2)
CJC:
100399152
(CA2)
SBQ:
101051669
(CA2)
CIMI:
108299489
(CA2)
ANAN:
105729997
(CA2)
CSYR:
103267642
MMUR:
105876545
(CA2)
LCAT:
123645210
(CA2)
PCOQ:
105809767
(CA2)
OGA:
100958433
(CA2)
MMU:
12349
(Car2)
MCAL:
110290838
(Ca2)
MPAH:
110320114
(Ca2)
RNO:
54231
(Car2)
MCOC:
116094960
(Ca2)
ANU:
117719135
MUN:
110565873
CGE:
100774844
(Ca2)
MAUA:
101822909
(Ca2)
PROB:
127231353
(Ca2)
PLEU:
114704100
MORG:
121432463
(Ca2)
MFOT:
126513412
AAMP:
119800670
119826287
(Ca2)
NGI:
103737199
(Ca2)
HGL:
101697802
(Ca2)
CPOC:
100719293
CCAN:
109696006
(Ca2)
DORD:
105982850
(Ca2)
DSP:
122096727
PLOP:
125360487
(Ca2)
NCAR:
124964038
OCU:
100009156
(CA2)
OPI:
101517573
(CA2)
TUP:
102489985
(CA2)
GVR:
103590417
(CA2)
CFA:
477928
(CA2)
CLUD:
112650731
(CA2)
VVP:
112931543
(CA2)
VLG:
121499147
(CA2)
NPO:
129495793
(CA2)
AML:
100474697
(CA2)
UMR:
103661462
(CA2)
UAH:
113252986
(CA2)
UAR:
123797918
ELK:
111146638
LLV:
125098721
MPUF:
101681304
(CA2)
MNP:
132014132
(CA2)
MLK:
131826639
(CA2)
NVS:
122904470
(CA2)
ORO:
101373598
(CA2)
EJU:
114214687
(CA2)
ZCA:
113932142
(CA2)
MLX:
118014981
(CA2)
NSU:
110579119
(CA2)
LWW:
102738329
(CA2)
FCA:
101094903
(CA2)
PYU:
121038035
(CA2)
PCOO:
112859736
(CA2)
PBG:
122495556
PVIV:
125156723
(CA2)
LRUF:
124507749
PTG:
102955030
(CA2)
PPAD:
109269438
(CA2)
PUC:
125924578
AJU:
106982309
HHV:
120246136
(CA2)
BTA:
280740
(CA2)
BOM:
102266781
(CA2)
BIU:
109568598
(CA2)
BBUB:
102416531
(CA2)
BBIS:
104993104
(CA2)
CHX:
102174762
OAS:
101113341
(CA2)
BTAX:
128059231
(CA2)
ODA:
120878526
(CA2)
CCAD:
122450824
(CA2)
MBEZ:
129560394
(CA2)
SSC:
100154873
CFR:
102512347
(CA2)
CBAI:
105066579
(CA2)
CDK:
105088502
(CA2)
BACU:
103014000
(CA2)
BMUS:
118883854
(CA2)
LVE:
103077109
(CA2)
OOR:
101289174
(CA2)
DLE:
111164950
(CA2)
PCAD:
102986103
(CA2)
PSIU:
116742742
(CA2)
NASI:
112390638
(CA2)
ECB:
100050059
(CA2)
EPZ:
103566710
(CA2)
EAI:
106829849
(CA2)
MYB:
102262761
(CA2)
MYD:
102764293
(CA2)
MMYO:
118670453
MLF:
102436958
MDT:
132219649
(CA2)
PKL:
118718501
(CA2)
EFUS:
103303360
(CA2)
MNA:
107526484
(CA2)
DRO:
112320764
(CA2)
SHON:
118989873
(CA2)
AJM:
119043148
(CA2)
PDIC:
114501998
PHAS:
123825823
(CA2)
MMF:
118631896
(CA2)
PPAM:
129088323
(CA2)
RFQ:
117033930
(CA2)
PALE:
102895979
(CA2)
PGIG:
120585564
(CA2)
PVP:
105302745
(CA2)
RAY:
107514919
(CA2)
MJV:
108401866
(CA2)
TOD:
119240114
(CA2)
SARA:
101555359
101558840
(CA2)
SETR:
126020647
(CA2)
LAV:
100662562
(CA2)
TMU:
101349680
ETF:
101660614
(CA2)
DNM:
101432091
(CA2)
MDO:
100025850
(CA2)
GAS:
123231640
123242877
123249967
SHR:
100918259
AFZ:
127543703
127564393
PCW:
110214700
(CA2)
TVP:
118834525
118840403
118851067
OAA:
100075583
GGA:
396257
(CA2)
PCOC:
116227582
MGP:
100539753
104910394
CJO:
107310310
TPAI:
128090827
LMUT:
125690418
NMEL:
110393964
APLA:
101802744
ACYG:
106030632
CATA:
118247955
AFUL:
116486233
TGU:
100224950
LSR:
110477417
SCAN:
103813316
PMOA:
120495786
OTC:
121340283
PRUF:
121351977
GFR:
102038402
(CA2)
FAB:
101818231
(CA2)
OMA:
130250334
PHI:
102102545
PMAJ:
107200179
CCAE:
111924584
CCW:
104692773
CBRC:
103613436
(CA2)
ETL:
114065898
(CA2)
ZAB:
102064495
ZLE:
135444616
ACHL:
103807028
(CA2)
SVG:
106849855
MMEA:
130576434
HRT:
120749946
SATI:
136369827
FPG:
101919433
(CA2)
FCH:
102050825
CCRI:
104168377
SHAB:
115619372
ACUN:
113476157
TALA:
104361638
ACHC:
115340683
HALD:
104316758
HLE:
104832155
(CA2)
AGEN:
126048417
GCL:
127029939
CSTI:
104552256
LDI:
104352502
MNB:
103768514
(CA2)
DPUB:
104309198
AVIT:
104278822
(CA2)
BRHI:
104495343
(CA2)
EGZ:
104123327
(CA2)
NNI:
104022793
(CA2)
PCRI:
104036482
PCAO:
104040699
PADL:
103924062
(CA2)
FGA:
104074484
GSTE:
104258925
CLV:
102091786
PGUU:
104464803
PLET:
104617071
(CA2)
EHS:
104508472
(CA2)
CMAC:
104474566
(CA2)
CUCA:
104056800
TEO:
104382245
(CA2)
BREG:
104640316
OHA:
104339442
(CA2)
CPEA:
104396560
CVF:
104292543
(CA2)
RTD:
128904816
AAM:
106496231
AROW:
112970920
NPD:
112960315
(CA2)
TGT:
104573108
(CA2)
DNE:
112982988
(CA2)
SCAM:
104143953
ASN:
102376447
(CA2)
AMJ:
102559447
(CA2)
CPOO:
109320129
GGN:
109305002
PSS:
102453298
(CA2)
CMY:
102930688
119563918
CCAY:
125624069
125632616
DCC:
119850560
CPIC:
101931774
101938201
(CA2)
TST:
117867615
117873630
CABI:
116820642
(CA2)
MRV:
120387556
120399209
ACS:
100552322
(ca2)
ASAO:
132774960
PVT:
110086873
SUND:
121928869
(CA2)
PBI:
103065165
PMUR:
107294436
(CA2)
107301657
CTIG:
120308861
(CA2)
TSR:
106540908
(CA2)
PGUT:
117668473
APRI:
131194945
(CA2)
PTEX:
113439933
NSS:
113428636
VKO:
123020342
PMUA:
114600457
(CA2)
PRAF:
128417293
ZVI:
118090305
(CA2)
HCG:
128324262
(CA2)
GJA:
107122376
(CA2)
STOW:
125438766
EMC:
129333152
(CA2)
XLA:
108719319
379058
(ca2.S)
379772
(ca2.L)
496283
XTR:
548446
(ca2)
780246
(car1_predicted)
NPR:
108786473
RTEM:
120941248
120941254
BBUF:
121000795
(CA2)
121001285
BGAR:
122922744
122937783
MUO:
115478650
GSH:
117355308
DRE:
30331
(cahz)
387526
(ca2)
SRX:
107731791
107732112
107751363
107755757
SANH:
107657784
107664098
107677316
107686019
SGH:
107550722
107554903
107585971
CAUA:
113042532
113045548
113068972
113077757
113085539
113092650
CGIB:
127945820
127950761
128013350
128029425
PTET:
122323969
122330109
(ca2)
LROH:
127155846
(ca2)
127178273
(cahz)
OMC:
131520311
(cahz)
131533628
(ca2)
PPRM:
120482703
(cahz)
120488158
(ca2)
RKG:
130078385
130084101
(ca2)
MAMB:
125251072
(cahz)
125257924
(ca2)
CIDE:
127499473
127506134
CERY:
137003365
(cahz)
137013545
(ca2)
MASI:
127431826
127434648
127440484
127442377
TROS:
130547254
(ca2)
130554928
(cahz)
TDW:
130413325
(ca2)
130418259
(cahz)
MANU:
129426253
(ca2)
129442164
(cahz)
IPU:
100528361
(cahz)
108265147
IFU:
128606100
128624168
(cahz)
PHYP:
113526888
113543047
SMEO:
124384399
124403340
(cahz)
TFD:
113640376
(cahz)
113649407
TVC:
132846274
132847969
(cahz)
TRN:
134302396
(cahz)
134309757
AMEX:
103021731
103030997
(cahz)
125801685
CMAO:
118796896
(cahz)
118823183
EEE:
113575687
(ca2)
CHAR:
105900523
(cahz)
105910902
TRU:
101067061
101075460
TFS:
130514217
130539472
(cahz)
TNG:
GSTEN00011437G001
GSTEN00025516G001
LCO:
104931498
104938779
NCC:
104942383
104953668
TBEN:
117473786
(cahz)
117497659
117498129
CGOB:
115025402
PGEO:
117442352
117462964
(cahz)
117465716
GACU:
117536249
117544747
117559694
EMAC:
134865984
(cahz)
134883947
ELY:
117264780
117271961
(cahz)
EFO:
125881758
125895504
125902833
(cahz)
PLEP:
121951443
(cahz)
121960751
SLUC:
116043909
(cahz)
116048581
ECRA:
117937833
117954648
(cahz)
ESP:
116672106
116699663
PFLV:
114549085
114565039
GAT:
120811536
120816137
(cahz)
120816334
PPUG:
119198468
119209297
(cahz)
AFB:
129094278
(cahz)
129110451
CLUM:
117746229
(cahz)
117749383
PSWI:
130197701
(cahz)
130206447
MSAM:
119901602
(cahz)
119912177
SCHU:
122866807
122886656
(cahz)
CUD:
121519803
(ca8)
121527616
ALAT:
119008564
119011013
(cahz)
MZE:
101465512
101475553
ONL:
100698193
100709107
OAU:
116310345
116322640
(cahz)
OLA:
101161087
101168081
OML:
112147241
(cahz)
112151462
CSAI:
133423668
133452285
(cahz)
XMA:
102225374
102230409
XCO:
114136870
114146736
XHE:
116711798
116721846
PRET:
103456787
PFOR:
103131821
103140569
PLAI:
106942139
106951300
PMEI:
106907080
106923814
GAF:
122823982
122840777
(cahz)
PPRL:
129352113
129362070
(cahz)
CVG:
107099263
107104089
CTUL:
119781460
119798431
GMU:
124858435
124868758
124869369
(cahz)
NFU:
107383032
107384348
KMR:
108228698
(cahz)
108230237
(ca2)
ALIM:
106515565
106525964
NWH:
119414365
119414860
119426513
AOCE:
111569220
111570373
MCEP:
124995711
125011326
(cahZ)
CSEM:
103377360
103396641
POV:
109639467
109639638
SSEN:
122765373
122777296
HHIP:
117753840
117767021
HSP:
118098607
118123437
PPLT:
128425617
128458355
SMAU:
118291210
118310945
(cahz)
LCF:
108896759
(cahz)
108900025
SDU:
111224337
111233273
SLAL:
111646404
111673646
XGL:
120789813
120799221
(cahz)
HCQ:
109524176
109524719
SSCV:
125985047
125985694
125985695
125985696
SBIA:
133492682
133511182
(cahz)
PEE:
133396412
133411386
(cahz)
PTAO:
133470302
133489211
(cahz)
BPEC:
110161277
110165516
MALB:
109951169
109962464
BSPL:
114844043
(cahz)
114854100
SJO:
128369077
(cahz)
128382048
SASA:
100195268
(cahz)
106590208
106599341
STRU:
115157040
115169734
115195711
OTW:
112226915
112227900
112260495
(cahz)
OMY:
100135826
100135827
(cahz)
110508700
OGO:
124009679
(cahz)
124039728
124041839
ONE:
115103065
115114443
115130311
OKI:
109871599
109874543
109899425
OKE:
118372584
118394683
118402083
(cahz)
SALP:
111953804
111956731
111979343
SNH:
120020064
120051106
120055890
(cahz)
CCLU:
121535246
(cahz)
121569366
121580943
ELS:
105024217
105026392
105031590
SFM:
108927765
108938304
PKI:
111838699
111846202
(ca2)
AANG:
118226188
118233831
(cahz)
LOC:
102686149
(ca2)
PSPA:
121314170
(cahz)
ARUT:
117394951
117400453
PSEX:
120530124
CMK:
103184961
PMRN:
116954150
116954174
LRJ:
133355916
133355919
133356013
BFO:
118418518
118418520
BBEL:
109473539
SCLV:
120330673
SPU:
577690
LPIC:
129254514
APLC:
110981370
110983275
ARUN:
117289119
AJC:
117109474
117122458
RZE:
108356319
SCAC:
106089132
106094503
AARA:
120897471
AMER:
121590459
AFUN:
125765328
AMOU:
128297784
AALI:
118459096
118460905
AAG:
5566891
AALB:
109622044
ASUA:
134224554
CQU:
CpipJ_CPIJ018437
CPII:
120413796
MGEN:
117222848
FEX:
115234707
PFUC:
122513935
NVI:
100123691
TPRE:
106649496
106656531
LBD:
127278636
MDL:
103572862
106694129
CGLO:
123258751
FAS:
105267653
105267856
DAM:
107040168
107043209
107048341
107048346
VCAN:
122408548
CCIN:
107262719
APLN:
108739107
PPYR:
116164918
OTU:
111417003
111420842
111422331
111429452
MSEX:
119189872
VCD:
124532426
MCIX:
123654890
PRAP:
123689388
SLIU:
111355698
ACOO:
126845665
126845737
HHAL:
106684408
HVI:
124358795
124360188
124360189
124361197
124361490
124362453
124362454
MQU:
128995335
129004876
129004909
CSEC:
111874633
IEL:
124168341
124168562
DMK:
116919181
PVM:
113817163
PJA:
122266655
PCHN:
125034622
125034623
125034624
125034625
PTRU:
123499199
HAZT:
108681742
EAF:
111704415
111708271
111708480
111711790
111712048
111712057
111713456
LSM:
121122347
TCF:
131889206
131892222
131893252
PPOI:
119090688
119090689
119093089
119094284
119105749
119105788
119106102
RSAN:
119388960
119391186
119405026
VDE:
111251595
VJA:
111272193
DPTE:
113789526
DFR:
124500356
PTEP:
107450528
107450531
UDV:
129227663
SDM:
118196005
LPOL:
106459495
PMEO:
129597044
129598040
NAI:
NECAME_06528
NECAME_06529
BMY:
BM_BM4831
(Bma-cah-3)
LOA:
LOAG_08956
LOAG_13353
HRO:
HELRODRAFT_65386
HELRODRAFT_71060
LGI:
LOTGIDRAFT_205401
PCAN:
112553390
BGT:
106062110
GAE:
121366167
121368129
121368865
121368869
121368870
121369147
121369148
121381776
HRF:
124123381
124123402
124131146
124140403
124144310
124144354
124144356
124144363
124147273
124147275
124147298
HRJ:
124264337
124264845
124288048
124292192
124292193
124292195
124292220
124292229
CRG:
105333462
105342594
105347585
117690307
CANU:
128178458
128181444
CVN:
111102140
111130106
111130107
111133247
111134104
OED:
125645563
125665669
125675393
125675406
130047076
MYI:
110447613
PMAX:
117337429
MCAF:
127703140
127703141
127703143
MMER:
123531633
123531655
123531680
123534416
123545414
DPOL:
127834121
127834123
127834125
127834555
127836127
127846145
127846343
127853895
MAEA:
128223786
128223788
128224659
128224660
128224663
128231076
128242134
OBI:
106879616
LJP:
135477809
SMM:
Smp_028670.1
OVI:
T265_07875
EGL:
EGR_07248
NVE:
5507293
5508237
EPA:
110250524
110250861
110250881
110251104
ATEN:
116293596
116297796
116306267
116306269
ADF:
107330479
107349784
107352682
107353128
AMIL:
114956785
114957406
114958848
114972776
PDAM:
113667207
113672902
113677715
113677716
113677718
113682220
113682239
113683909
SPIS:
111327039
111330399
111330400
111333012
111337799
111337813
111339021
111339044
111339045
111344412
XEN:
124433990
124433998
124434005
124441797
HSY:
130613677
130622589
130629760
RES:
135683467
135683597
TAD:
TRIADDRAFT_18628
TRIADDRAFT_51646
TRIADDRAFT_51649
AQU:
100631784
» show all
Taxonomy
UniProt
Reference
PMID:
15990874
Authors
Alvarez BV, Vilas GL, Casey JR
Title
Metabolon disruption: a mechanism that regulates bicarbonate transport.
Journal
EMBO J 24:2499-511 (2005)
DOI:
10.1038/sj.emboj.7600736
Sequence
[hsa:
760
]
LinkDB
All DBs
DBGET
integrated database retrieval system