KEGG   DRUG: BaclofenHelp
Entry
D00241                      Drug                                   

Name
Baclofen (JP17/USP/INN);
Kemstro (TN);
Lioresal (TN)
Product
  Generic
BACLOFEN (Aidarex Pharmaceuticals LLC), BACLOFEN (American Health Packaging), BACLOFEN (Aphena Pharma Solutions - Tennessee), BACLOFEN (Atlantic Biologicals Corps), BACLOFEN (AvKARE), BACLOFEN (Blenheim Pharmacal), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Cardinal Health), BACLOFEN (Clinical Solutions Wholesale), BACLOFEN (DIRECT RX), BACLOFEN (DIRECT RX), BACLOFEN (Direct Rx), BACLOFEN (Dispensing Solutions), BACLOFEN (H.J. Harkins Company), BACLOFEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lannett Company), BACLOFEN (Major Pharmaceuticals), BACLOFEN (Major Pharmaceuticals), BACLOFEN (Marlex Pharmaceuticals), BACLOFEN (McKesson Corporation), BACLOFEN (McKesson Corporation), BACLOFEN (Med Health Pharma), BACLOFEN (Medsource Pharmaceuticals), BACLOFEN (Mylan Institutional LLC), BACLOFEN (Mylan Institutional LLC), BACLOFEN (NCS HealthCare of KY), BACLOFEN (New Horizon Rx Group), BACLOFEN (Northstar RxLLC), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (PD-Rx Pharmaceuticals), BACLOFEN (PD-Rx Pharmaceuticals), BACLOFEN (Par Pharmaceutical), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Proficient Rx LP), BACLOFEN (Proficient Rx LP), BACLOFEN (Proficient Rx LP), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (Rebel Distributors Corp), BACLOFEN (Rebel Distributors Corp.), BACLOFEN (Sintetica S.A.), BACLOFEN (St Marys Medical Park Pharmacy), BACLOFEN (State of Florida DOH Central Pharmacy), BACLOFEN (Teva Pharmaceuticals USA), BACLOFEN (TruPharma LLC), BACLOFEN (Unit Dose Services), BACLOFEN (Unit Dose Services), BACLOFEN (Unit Dose Services), BACLOFEN (Unit Dose Services), BACLOFEN (Upsher-Smith Laboratories), BACLOFEN (Upsher-Smith Laboratories)
Formula
C10H12ClNO2
Exact mass
213.0557
Mol weight
213.6608
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01565  GABA-B receptor agonist
Other
 DG02029  Muscle relaxant
  DG01974  Centrally acting muscle relaxant
 DG01974  Centrally acting muscle relaxant
Remark
Therapeutic category: 1249
ATC code: M03BX01
Product: D00241<JP/US>
Efficacy
Antispasmodic, Muscle relaxant, GABA-B receptor agonist
Comment
GABA (gamma-aminobutyric acid) mimetic
Target
GABBR [HSA:2550 9568] [KO:K04615]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
    M03BX Other centrally acting agents
     M03BX01 Baclofen
      D00241  Baclofen (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antispasticity Agents
  Baclofen
   D00241  Baclofen (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1249  Others
     D00241  Baclofen (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Metabotropic glutamate receptor family
   GABA (metabotropic)
    GABBR
     D00241  Baclofen (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00241  Baclofen
  D00241  Baclofen tablets
BRITE hierarchy
Other DBs
CAS: 1134-47-0
PubChem: 7847307
ChEBI: 2972
ChEMBL: CHEMBL701
DrugBank: DB00181
LigandBox: D00241
NIKKAJI: J3.661G
LinkDB All DBs
KCF data Show

ATOM        14
            1   C8y C    21.8514  -16.2984
            2   C1c C    21.8514  -14.8937
            3   C8x C    20.6389  -17.0038
            4   C8x C    23.0637  -17.0038
            5   C1b C    20.6448  -14.2001
            6   C1b C    23.0637  -14.2001
            7   C8x C    20.6389  -18.4027
            8   C8x C    23.0637  -18.4027
            9   C6a C    19.4265  -14.8937
            10  N1a N    24.2820  -14.8937
            11  C8y C    21.8514  -19.1022
            12  O6a O    18.2140  -14.2001
            13  O6a O    19.4265  -16.2984
            14  X   Cl   21.8514  -20.5011
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    7  11 1
            11    9  12 1
            12    9  13 2
            13   11  14 1
            14    8  11 2

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