KEGG   DRUG: BetamethasoneHelp
Entry
D00244                      Drug                                   

Name
Betamethasone (JP17/USP/INN);
Celestone (TN);
Rinderon (TN)
Formula
C22H29FO5
Exact mass
392.1999
Mol weight
392.4611
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C06848
Therapeutic category: 2454
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Product (mixture): D04447<JP> D10300<US>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D00244  Betamethasone (JP17/USP/INN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Betamethasone
   D00244  Betamethasone (JP17/USP/INN)
  Betamethasone
   D00244  Betamethasone (JP17/USP/INN)
  Betamethasone
   D00244  Betamethasone (JP17/USP/INN)
  Betamethasone
   D00244  Betamethasone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Betamethasone
    D00244  Betamethasone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00244  Betamethasone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00244  Betamethasone (JP17/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00244  Betamethasone
  D00244  Betamethasone tablets
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D00244
 Respiratory agents
  D00244
BRITE hierarchy
Other DBs
CAS: 378-44-9
PubChem: 7847310
ChEBI: 3077
ChEMBL: CHEMBL1377507 CHEMBL1610678 CHEMBL632
DrugBank: DB00443
LigandBox: D00244
NIKKAJI: J2.038I
LinkDB All DBs
KCF data Show

ATOM        28
            1   C2x C     6.7900  -14.9100
            2   C5x C     6.7900  -16.3100
            3   C2x C     8.0024  -17.0100
            4   C2y C     9.2149  -16.3100
            5   C1z C     9.2149  -14.9100
            6   C2x C     8.0024  -14.2100
            7   C1x C    10.4273  -17.0100
            8   C1x C    11.6397  -16.3100
            9   C1y C    11.6397  -14.9100
            10  C1z C    10.4273  -14.2100
            11  C1y C    12.8522  -14.2100
            12  C1z C    12.8522  -12.8100
            13  C1x C    11.6397  -12.1100
            14  C1y C    10.4273  -12.8100
            15  C1x C    15.2770  -14.2100
            16  C1y C    15.2770  -12.8100
            17  C1z C    14.0646  -12.1100
            18  C1a C     9.2149  -13.5100
            19  O1a O     9.2169  -12.1112
            20  C1a C    12.8522  -11.4100
            21  C1a C    16.4766  -12.1173
            22  C5a C    14.0646  -10.3600
            23  X   F    10.4273  -15.6100
            24  O1a O    15.2770  -11.4100
            25  O5x O     5.5776  -17.0100
            26  O5a O    15.2811   -9.6577
            27  C1b C    12.8562   -9.6623
            28  O1a O    11.6627  -10.3516
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Up
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1

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