KEGG   DRUG: Dacarbazine
Entry
D00288                      Drug                                   
Name
Dacarbazine (JAN/USP/INN);
DTIC-Dome (TN)
Product
  Generic
DACARBAZINE (Fresenius Kabi USA), DACARBAZINE (Hikma Pharmaceuticals USA), DACARBAZINE (Meitheal Pharmaceuticals)
Formula
C6H10N6O
Exact mass
182.0916
Mol weight
182.18
Structure
Simcomp
Class
Antineoplastic
 DG01677  Alkylating agent
Remark
Same as: C06936
Therapeutic category: 4219
ATC code: L01AX04
Chemical structure group: DG00680
Product (DG00680): D00288<JP/US>
Efficacy
Antineoplastic, Alkylating agent
  Disease
Malignant melanoma [DS:H00038]
Hodgkin's disease [DS:H00007]
Target
DNA
RNA
Interaction
Structure map
map07040  Antineoplastics - alkylating agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AX Other alkylating agents
     L01AX04 Dacarbazine
      D00288  Dacarbazine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Alkylating Agents, Other
    Dacarbazine
     D00288  Dacarbazine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   421  Alkylating agents
    4219  Others
     D00288  Dacarbazine (JAN/USP/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   DG00680  Dacarbazine
    D00288  Dacarbazine
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   DG00680  Dacarbazine
Other DBs
CAS: 4342-03-4
PubChem: 7847354
ChEBI: 4305
LigandBox: D00288
NIKKAJI: J2.212H
LinkDB
KCF data

ATOM        13
            1   C8y C    19.2500  -18.5500
            2   C8y C    19.2500  -19.9500
            3   N5x N    20.5815  -20.3826
            4   C8x C    21.4044  -19.2500
            5   N4x N    20.5815  -18.1174
            6   N2b N    18.0376  -17.8500
            7   N2b N    16.8251  -18.5500
            8   N1a N    16.8251  -19.9500
            9   C5a C    18.0376  -20.6500
            10  O5a O    18.0376  -22.0498
            11  N1c N    15.5940  -17.8390
            12  C1a C    14.3888  -18.5347
            13  C1a C    15.5943  -16.4501
BOND        13
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 2
            8     8   9 1
            9     2   9 1
            10    9  10 2
            11    7  11 1
            12   11  12 1
            13   11  13 1

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KEGG   DRUG: Dacarbazine citrate
Entry
D07772                      Drug                                   
Name
Dacarbazine citrate
Formula
C6H8O7. C6H10N6O
Exact mass
374.1186
Mol weight
374.31
Structure
Class
Antineoplastic
 DG01677  Alkylating agent
Remark
ATC code: L01AX04
Chemical structure group: DG00680
Product (DG00680): D00288<JP/US>
Efficacy
Antineoplastic, Alkylating agent
Target
DNA
RNA
Interaction
Structure map
map07040  Antineoplastics - alkylating agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AX Other alkylating agents
     L01AX04 Dacarbazine
      D07772  Dacarbazine citrate
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   DG00680  Dacarbazine
    D07772  Dacarbazine citrate
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   DG00680  Dacarbazine
Other DBs
CAS: 64038-56-8
PubChem: 96024470
LigandBox: D07772
LinkDB
KCF data

ATOM        26
            1   C8y C    21.0732   -6.8628
            2   C8y C    21.0732   -8.2631
            3   N5x N    22.4034   -8.6831
            4   C8x C    23.2435   -7.5630
            5   N4x N    22.4034   -6.4428
            6   N2b N    19.8830   -6.1627
            7   N2b N    18.6228   -6.8628
            8   N1a N    18.6228   -8.2631
            9   C5a C    19.8830   -8.9632
            10  O5a O    19.8830  -10.3634
            11  N1c N    17.4326   -6.1627
            12  C1a C    16.2424   -6.8628
            13  C1a C    17.4326   -4.7625
            14  C1d C    29.8200   -7.0000
            15  C1b C    28.6300   -7.7000
            16  C1b C    31.0100   -7.7000
            17  C6a C    30.5200   -5.8100
            18  O1a O    29.1200   -5.8100
            19  C6a C    27.4400   -7.0700
            20  C6a C    31.0100   -9.1000
            21  O6a O    29.8200   -4.6200
            22  O6a O    31.9200   -5.8100
            23  O6a O    26.1800   -7.7700
            24  O6a O    27.4400   -5.6700
            25  O6a O    32.2700   -9.8000
            26  O6a O    29.8200   -9.8000
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 2
            8     8   9 1
            9     2   9 1
            10    9  10 2
            11    7  11 1
            12   11  12 1
            13   11  13 1
            14   14  15 1
            15   14  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   16  20 1
            20   17  21 1
            21   17  22 2
            22   19  23 1
            23   19  24 2
            24   20  25 1
            25   20  26 2

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