KEGG   DRUG: DigoxinHelp
Entry
D00298                      Drug                                   

Name
Digoxin (JP17/USP);
Lanoxicaps (TN);
Lanoxin (TN)
Product
  Generic
DIGOX (Aidarex Pharmaceuticals LLC), DIGOXIN (American Health Packaging), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Cardinal Health), DIGOXIN (Cardinal Health), DIGOX (Carilion Materials Management), DIGOX (Carilion Materials Management), DIGOXIN (Clinical Solutions Wholesale), DIGOXIN (DEPT HEALTH CENTRAL PHARMACY), DIGOXIN (General Injectables and Vaccines), DIGOXIN (Golden State Medical Supply), DIGOXIN (HF Acquisition Co LLC), DIGOXIN (Impax Generics), DIGOXIN (Jerome Stevens Pharmaceuticals), DIGOX (Lake Erie Medical DBA Quality Care Products LLC), DIGOX (Lake Erie Medical DBA Quality Care Products LLC), DIGOX (Lannett Company), DIGOXIN (Major Pharmaceuticals), DIGITEK (Mylan Institutional), DIGITEK (Mylan Pharmaceuticals), DIGOXIN (NCS HealthCare of KY), DIGOXIN (NCS HealthCare of KY), DIGOXIN (NCS HealthCare of KY), DIGOXIN (NCS HealthCare of KY), DIGOXIN (NCS HealthCare of KY), DIGOXIN (Northstar Rx LLC), DIGOXIN (Northwind Pharmaceuticals), DIGOXIN (Northwind Pharmaceuticals), DIGOXIN (NuCare Pharmaceuticals), DIGOXIN (NuCare Pharmaceuticals), DIGOXIN (NuCare Pharmaceuticals), DIGOXIN (NuCare Pharmaceuticals), DIGOXIN (NuCare Pharmaceuticals), DIGOXIN (NuCare Pharmaceuticals), DIGOXIN (PD-Rx Pharmaceuticals), DIGOX (PD-Rx Pharmaceuticals), DIGOXIN (Par Pharmaceutical), DIGOX (Proficient Rx LP), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (Sandoz), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOXIN (Sun Pharmaceutical Industries), DIGOX (TYA Pharmaceuticals), DIGOXIN (Unit Dose Services), DIGOXIN (Unit Dose Services), DIGOXIN (Unit Dose Services), DIGOXIN (Unit Dose Services), DIGOXIN (West-Ward Pharmaceuticals Corp), DIGOXIN (West-Ward Pharmaceuticals Corp.), DIGOXIN (West-Ward Pharmaceuticals Corp.)
Formula
C41H64O14
Exact mass
780.4296
Mol weight
780.9385
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01698  Cardiac glycoside
   DG01697  Digitalis cardiac glycoside
 DG01653  Antiarrhythmics
Transporter substrate
 DG01665  ABCB1(P-GP) substrate
Remark
Same as: C06956
Therapeutic category: 2113
ATC code: C01AA05
Product: D00298<JP/US>
Efficacy
Cardiotonic
Comment
Digitalis glycoside
Target
ATP1A [HSA:476 477 478 480] [KO:K01539]
  Pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Structure map
map07233  Ion transporter inhibitors
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01A CARDIAC GLYCOSIDES
    C01AA Digitalis glycosides
     C01AA05 Digoxin
      D00298  Digoxin (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Other
   Digoxin
    D00298  Digoxin (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2113  Digitalis
     D00298  Digoxin (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP1A
     D00298  Digoxin (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00298  Digoxin
  D00298  Digoxin tablets
  D00298  Digoxin injection
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00298
BRITE hierarchy
Other DBs
CAS: 20830-75-5
PubChem: 7847364
ChEBI: 4551
ChEMBL: CHEMBL1751
DrugBank: DB00390
PDB-CCD: DGX[PDBj]
LigandBox: D00298
NIKKAJI: J4.082G
LinkDB All DBs
KCF data Show

ATOM        55
            1   O2a O    19.8800  -19.5300
            2   C1y C    21.0700  -18.7600
            3   C1x C    22.2600  -19.4600
            4   C1y C    23.4500  -18.7600
            5   C1z C    23.4500  -17.3600
            6   C1x C    22.2600  -16.6600
            7   C1x C    21.0700  -17.3600
            8   C1x C    24.7100  -19.4600
            9   C1x C    25.9000  -18.7600
            10  C1y C    25.9000  -17.3600
            11  C1y C    24.7100  -16.6600
            12  C1z C    27.0900  -16.6600
            13  C1z C    27.0900  -15.2600
            14  C1y C    25.9000  -14.5600
            15  C1x C    24.7100  -15.2600
            16  C1a C    27.0900  -13.8600
            17  O1a O    27.0900  -18.0600
            18  C1a C    23.4500  -15.9600
            19  C1y C    18.6200  -18.9000
            20  O2x O    18.6200  -17.5000
            21  C1y C    17.3600  -16.8000
            22  C1y C    16.1700  -17.5000
            23  C1y C    16.1700  -18.9000
            24  C1x C    17.3600  -19.6000
            25  O2a O    14.9800  -16.8000
            26  C1y C    13.7900  -17.5000
            27  O2x O    13.7900  -18.9000
            28  O1a O    14.9800  -19.6000
            29  C1x C    12.5300  -16.8000
            30  C1y C    11.3400  -17.5000
            31  C1y C    11.3400  -18.9000
            32  C1y C    12.5300  -19.6000
            33  O1a O    10.1500  -16.8000
            34  O2x O     8.8900  -17.5000
            35  C1y C     8.8900  -18.9000
            36  O2a O    10.1500  -19.6000
            37  C1y C     7.7000  -16.8000
            38  C1y C     6.5100  -17.5000
            39  C1y C     6.5100  -18.9000
            40  C1x C     7.7000  -19.6000
            41  O1a O     5.2500  -16.8000
            42  O1a O     5.2500  -19.6000
            43  C1a C    17.3600  -15.4000
            44  C1a C    12.5300  -21.0000
            45  C1a C     7.7000  -15.4000
            46  O1a O    25.9000  -13.1600
            47  C1x C    29.5400  -16.6600
            48  C1x C    29.5400  -15.2600
            49  C1y C    28.2800  -14.5600
            50  C2y C    28.2800  -13.1600
            51  C2x C    29.7500  -13.1600
            52  C7x C    30.1700  -11.8300
            53  O7x O    29.0500  -10.9900
            54  C1x C    27.9300  -11.7600
            55  O6a O    31.5000  -11.4100
BOND        62
            1     2   1 1 #Up
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    5  11 1
            13   10  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   11  15 1
            18   13  16 1 #Up
            19   12  17 1 #Up
            20    5  18 1 #Up
            21   19   1 1 #Up
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1 #Down
            29   26  25 1 #Down
            30   26  27 1
            31   23  28 1 #Down
            32   26  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   27  32 1
            37   30  33 1 #Up
            38   34  35 1
            39   35  36 1 #Up
            40   31  36 1 #Up
            41   34  37 1
            42   37  38 1
            43   38  39 1
            44   39  40 1
            45   35  40 1
            46   38  41 1 #Down
            47   39  42 1 #Down
            48   21  43 1 #Up
            49   32  44 1 #Down
            50   37  45 1 #Up
            51   14  46 1 #Up
            52   12  47 1
            53   47  48 1
            54   48  49 1
            55   13  49 1
            56   49  50 1 #Up
            57   50  51 2
            58   51  52 1
            59   52  53 1
            60   53  54 1
            61   52  55 2
            62   50  54 1

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