KEGG   DRUG: Enoxacin
Entry
D00310                      Drug                                   
Name
Enoxacin (USAN/INN);
Penetrex (TN)
Formula
C15H17FN4O3
Exact mass
320.1285
Mol weight
320.32
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
Same as: C06979
ATC code: J01MA04
Chemical structure group: DG00619
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Target
DNA gyrase [KO:K02469 K02470]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Structure map
map07014  Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA04 Enoxacin
      D00310  Enoxacin (USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00619  Enoxacin
     D00310  Enoxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00619  Enoxacin
    D00310  Enoxacin
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D00310  Enoxacin (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00310
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00619  Enoxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00619  Enoxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00619  Enoxacin
Other DBs
CAS: 74011-58-8
PubChem: 7847376
ChEBI: 157175
LigandBox: D00310
NIKKAJI: J20.568K
LinkDB
KCF data

ATOM        23
            1   C8y C    22.3469  -17.3424
            2   C8y C    22.3528  -15.9491
            3   N4y N    23.5535  -18.0535
            4   N5x N    21.1462  -18.0535
            5   C8y C    23.5652  -15.2613
            6   C8x C    21.1462  -15.2496
            7   C8x C    24.7660  -17.3598
            8   C1b C    23.5418  -19.4523
            9   C8y C    19.9337  -17.3481
            10  C8y C    24.7718  -15.9608
            11  O5x O    23.5768  -13.8566
            12  C8y C    19.9279  -15.9434
            13  C1a C    22.3236  -20.1461
            14  N1y N    18.7154  -18.0476
            15  C6a C    25.9958  -15.2730
            16  X   F    18.7154  -15.2496
            17  C1x C    18.7154  -19.4523
            18  C1x C    17.5030  -17.3424
            19  O6a O    27.2024  -15.9784
            20  O6a O    26.0017  -13.8682
            21  C1x C    17.5030  -20.1461
            22  C1x C    16.2907  -18.0476
            23  N1x N    16.2907  -19.4523
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1

» Japanese version   » Back

KEGG   DRUG: Enoxacin hydrate
Entry
D05461                      Drug                                   
Name
Enoxacin hydrate (JP18)
Formula
(C15H17FN4O3)3. 2H2O
Exact mass
996.4065
Mol weight
996.99
Structure
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
ATC code: J01MA04
Chemical structure group: DG00619
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Target
DNA gyrase [KO:K02469 K02470]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Structure map
map07014  Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA04 Enoxacin
      D05461  Enoxacin hydrate (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00619  Enoxacin
     D05461  Enoxacin hydrate
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00619  Enoxacin
    D05461  Enoxacin hydrate
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D05461  Enoxacin hydrate (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D05461  Enoxacin hydrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05461
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00619  Enoxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00619  Enoxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00619  Enoxacin
Other DBs
CAS: 84294-96-2
PubChem: 47207130
LigandBox: D05461
LinkDB
KCF data

ATOM        71
            1   C8y C    30.8700  -15.8200
            2   C8y C    30.8700  -14.4200
            3   N4y N    32.0600  -16.5200
            4   N5x N    29.6800  -16.5200
            5   C8y C    32.1300  -13.7200
            6   C8x C    29.6800  -13.7200
            7   C8x C    33.3200  -15.8200
            8   C1b C    32.0600  -17.9200
            9   C8y C    28.4900  -15.8200
            10  C8y C    33.3200  -14.4200
            11  O5x O    32.1300  -12.3200
            12  C8y C    28.4900  -14.4200
            13  C1a C    30.8700  -18.6200
            14  N1y N    27.2300  -16.5200
            15  C6a C    34.5100  -13.7200
            16  X   F    27.2300  -13.7200
            17  C1x C    27.2300  -17.9200
            18  C1x C    26.0400  -15.8200
            19  O6a O    35.7700  -14.4200
            20  O6a O    34.5100  -12.3200
            21  C1x C    26.0400  -18.6200
            22  C1x C    24.8500  -16.5200
            23  N1x N    24.8500  -17.9200
            24  O0  O    40.1100  -15.5400
            25  C8y C    30.8700  -15.8200
            26  C8y C    30.8700  -14.4200
            27  C8y C    32.1300  -13.7200
            28  C8y C    33.3200  -14.4200
            29  C6a C    34.5100  -13.7200
            30  O6a O    35.7700  -14.4200
            31  O6a O    34.5100  -12.3200
            32  C8x C    33.3200  -15.8200
            33  N4y N    32.0600  -16.5200
            34  C1b C    32.0600  -17.9200
            35  C1a C    30.8700  -18.6200
            36  O5x O    32.1300  -12.3200
            37  C8x C    29.6800  -13.7200
            38  C8y C    28.4900  -14.4200
            39  X   F    27.2300  -13.7200
            40  C8y C    28.4900  -15.8200
            41  N5x N    29.6800  -16.5200
            42  N1y N    27.2300  -16.5200
            43  C1x C    27.2300  -17.9200
            44  C1x C    26.0400  -18.6200
            45  N1x N    24.8500  -17.9200
            46  C1x C    24.8500  -16.5200
            47  C1x C    26.0400  -15.8200
            48  C8y C    30.8700  -15.8200
            49  C8y C    30.8700  -14.4200
            50  C8y C    32.1300  -13.7200
            51  C8y C    33.3200  -14.4200
            52  C6a C    34.5100  -13.7200
            53  O6a O    35.7700  -14.4200
            54  O6a O    34.5100  -12.3200
            55  C8x C    33.3200  -15.8200
            56  N4y N    32.0600  -16.5200
            57  C1b C    32.0600  -17.9200
            58  C1a C    30.8700  -18.6200
            59  O5x O    32.1300  -12.3200
            60  C8x C    29.6800  -13.7200
            61  C8y C    28.4900  -14.4200
            62  X   F    27.2300  -13.7200
            63  C8y C    28.4900  -15.8200
            64  N5x N    29.6800  -16.5200
            65  N1y N    27.2300  -16.5200
            66  C1x C    27.2300  -17.9200
            67  C1x C    26.0400  -18.6200
            68  N1x N    24.8500  -17.9200
            69  C1x C    24.8500  -16.5200
            70  C1x C    26.0400  -15.8200
            71  O0  O    40.1100  -15.5400
BOND        75
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1
            26   25  26 2
            27   25  33 1
            28   25  41 1
            29   26  27 1
            30   26  37 1
            31   33  32 1
            32   33  34 1
            33   41  40 2
            34   27  28 1
            35   27  36 2
            36   37  38 2
            37   34  35 1
            38   40  42 1
            39   28  29 1
            40   38  39 1
            41   42  43 1
            42   42  47 1
            43   29  30 1
            44   29  31 2
            45   43  44 1
            46   47  46 1
            47   44  45 1
            48   32  28 2
            49   40  38 1
            50   46  45 1
            51   48  49 2
            52   48  56 1
            53   48  64 1
            54   49  50 1
            55   49  60 1
            56   56  55 1
            57   56  57 1
            58   64  63 2
            59   50  51 1
            60   50  59 2
            61   60  61 2
            62   57  58 1
            63   63  65 1
            64   51  52 1
            65   61  62 1
            66   65  66 1
            67   65  70 1
            68   52  53 1
            69   52  54 2
            70   66  67 1
            71   70  69 1
            72   67  68 1
            73   55  51 2
            74   63  61 1
            75   69  68 1
BRACKET     1    23.3100  -19.3900   23.3100  -11.8300
            1    37.1000  -11.8300   37.1000  -19.3900
            1  3
 ORIGINAL  1    1   2   5  10  15  19  20   7   3   8  13  11   6  12  16   9
            1    4  14  17  21  23  22  18
 REPEAT    1   25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
            1   41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56
            1   57  58  59  60  61  62  63  64  65  66  67  68  69  70
            2    38.1500  -16.3800   38.1500  -14.7000
            2    40.6000  -14.7000   40.6000  -16.3800
            2  2
 ORIGINAL  2   24
 REPEAT    2   71

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