KEGG   Homo sapiens (human): 1544
Entry
1544              CDS       T01001                                 
Symbol
CYP1A2, CP12, CYPIA2, P3-450, P450(PA)
Name
(RefSeq) cytochrome P450 family 1 subfamily A member 2
  KO
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00232  Caffeine metabolism
hsa00380  Tryptophan metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06250  DNA adduct formation (cancer)
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01369  4-ABP to DNA adducts
N01370  PhIP to DNA adducts
N01371  PhIP to DNA adducts
N01372  IQ to DNA adducts
N01373  MeIQx to DNA adducts
N01378  AFB1 to DNA adducts
N01396  4-Aminobiphenyl to CYP-mediated metabolism
N01397  4-Aminobiphenyl to CYP-mediated metabolism
N01398  Pentachlorophenol to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1544 (CYP1A2)
   00591 Linoleic acid metabolism
    1544 (CYP1A2)
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    1544 (CYP1A2)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1544 (CYP1A2)
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    1544 (CYP1A2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1544 (CYP1A2)
   00982 Drug metabolism - cytochrome P450
    1544 (CYP1A2)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1544 (CYP1A2)
   05207 Chemical carcinogenesis - receptor activation
    1544 (CYP1A2)
   05208 Chemical carcinogenesis - reactive oxygen species
    1544 (CYP1A2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1544 (CYP1A2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1544 (CYP1A2)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP1 family
   1544 (CYP1A2)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1544
NCBI-ProteinID: NP_000752
OMIM: 124060
HGNC: 2596
Ensembl: ENSG00000140505
UniProt: P05177
Structure
LinkDB
Position
15:74748845..74756607
AA seq 516 aa
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
NT seq 1551 nt   +upstreamnt  +downstreamnt
atggcattgtcccagtctgttcccttctcggccacagagcttctcctggcctctgccatc
ttctgcctggtattctgggtgctcaagggtttgaggcctcgggtccccaaaggcctgaaa
agtccaccagagccatggggctggcccttgctcgggcatgtgctgaccctggggaagaac
ccgcacctggcactgtcaaggatgagccagcgctacggggacgtcctgcagatccgcatt
ggctccacgcccgtgctggtgctgagccgcctggacaccatccggcaggccctggtgcgg
cagggcgacgatttcaagggccggcctgacctctacacctccaccctcatcactgatggc
cagagcttgaccttcagcacagactctggaccggtgtgggctgcccgccggcgcctggcc
cagaatgccctcaacaccttctccatcgcctctgacccagcttcctcatcctcctgctac
ctggaggagcatgtgagcaaggaggctaaggccctgatcagcaggttgcaggagctgatg
gcagggcctgggcacttcgacccttacaatcaggtggtggtgtcagtggccaacgtcatt
ggtgccatgtgcttcggacagcacttccctgagagtagcgatgagatgctcagcctcgtg
aagaacactcatgagttcgtggagactgcctcctccgggaaccccctggacttcttcccc
atccttcgctacctgcctaaccctgccctgcagaggttcaaggccttcaaccagaggttc
ctgtggttcctgcagaaaacagtccaggagcactatcaggactttgacaagaacagtgtc
cgggacatcacgggtgccctgttcaagcacagcaagaaggggcctagagccagcggcaac
ctcatcccacaggagaagattgtcaaccttgtcaatgacatctttggagcaggatttgac
acagtcaccacagccatctcctggagcctcatgtaccttgtgaccaagcctgagatacag
aggaagatccagaaggagctggacactgtgattggcagggagcggcggccccggctctct
gacagaccccagctgccctacttggaggccttcatcctggagaccttccgacactcctcc
ttcttgcccttcaccatcccccacagcacaacaagggacacaacgctgaatggcttctac
atccccaagaaatgctgtgtcttcgtaaaccagtggcaggtcaaccatgacccagagctg
tgggaggacccctctgagttccggcctgagcggttcctcaccgccgatggcactgccatt
aacaagcccttgagtgagaagatgatgctgtttggcatgggcaagcgccggtgtatcggg
gaagtcctggccaagtgggagatcttcctcttcctggccatcctgctacagcaactggag
ttcagcgtgccgccgggcgtgaaagtcgacctgacccccatctacgggctgaccatgaag
cacgcccgctgtgaacatgtccaggcgcggctgcgcttctccatcaattga

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