Entry |
|
Name |
Itraconazole (JP18/USP); Itrizole (TN); Sporanox (TN) |
Abbr |
ITC |
Product |
|
Generic |
ITRACONAZOLE (Alembic Pharmaceuticals Limited), ITRACONAZOLE (Alembic Pharmaceuticals), ITRACONAZOLE (American Health Packaging), ITRACONAZOLE (Amneal Pharmaceuticals LLC), ITRACONAZOLE (Amneal Pharmaceuticals LLC), ITRACONAZOLE (Ascend Laboratories), ITRACONAZOLE (AvPAK), ITRACONAZOLE (Camber Pharmaceuticals), ITRACONAZOLE (NorthStar RxLLC), ITRACONAZOLE (Par Pharmaceutical), ITRACONAZOLE (REMEDYREPACK), ITRACONAZOLE (Rising Pharma Holdings), ITRACONAZOLE (Torrent Pharmaceuticals Limited), ITRACONAZOLE (Zydus Lifesciences Limited), ITRACONAZOLE (Zydus Pharmaceuticals USA), ITRACONAZOLE ORAL (Natco Pharma USA LLC) |
Formula |
C35H38Cl2N8O4
|
Exact mass |
704.2393
|
Mol weight |
705.63
|
Structure |

|
Simcomp |
|
Class |
Antifungal
DG01523 Triazole antifungal
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
Remark |
Therapeutic category: | 6290 |
|
Efficacy |
Antifungal, Ergosterol biosynthesis inhibitor |
Disease |
Blastomycosis [DS: H01501] Histoplasmosis [DS: H01062] Aspergillosis [DS: H01328] Onychomycosis of the toenail, fingernail [DS: H01316] |
Target |
sterol 14alpha-demethylase [KO: K05917] |
Pathway |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
Transporter inhibition: ABCB1 [HSA: 5243]
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AC Triazole and tetrazole derivatives
J02AC02 Itraconazole
D00350 Itraconazole (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antifungals
Itraconazole
D00350 Itraconazole (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D00350 Itraconazole (JP18/USP)
Drug groups [BR:br08330]
Antifungal
DG01523 Triazole antifungal
D00350 Itraconazole
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00350 Itraconazole
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
D00350 Itraconazole
Transporter inhibitor
DG01622 ABCB1 inhibitor
D00350 Itraconazole
Drug classes [BR:br08332]
Antifungal
DG01523 Triazole antifungal
D00350 Itraconazole
Antimicrobials [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
Triazole
D00350 Itraconazole (JP18/USP) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antifungals
Ergosterol biosynthesis inhibitor
Triazole
D00350 Itraconazole (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00350 Itraconazole
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00350
Drug transporters
D00350
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Other DBs |
|
LinkDB |
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KCF data |
ATOM 49
1 C8x C 19.8100 -8.8900
2 C8x C 21.2100 -8.8900
3 C8y C 21.9100 -7.6776
4 C8x C 21.2100 -6.4651
5 C8x C 19.8100 -6.4651
6 C8y C 19.1100 -7.6776
7 N1y N 23.3098 -7.6776
8 C1x C 24.0197 -8.9068
9 C1x C 25.4197 -8.9066
10 N1y N 26.1196 -7.6941
11 C1x C 25.4097 -6.4649
12 C1x C 24.0097 -6.4651
13 C8y C 27.5100 -7.6940
14 C8x C 28.2127 -8.9109
15 C8x C 29.6127 -8.9108
16 C8y C 30.3126 -7.6983
17 C8x C 29.6099 -6.4814
18 C8x C 28.2099 -6.4815
19 N4y N 31.7100 -7.6981
20 C8y C 32.5339 -8.8319
21 N4y N 33.8668 -8.3987
22 N5x N 33.8666 -6.9972
23 C8x C 32.5337 -6.5642
24 O2a O 17.7102 -7.6776
25 C1b C 17.0004 -8.9068
26 C1y C 15.6101 -8.9066
27 O5x O 32.1066 -10.1479
28 C1c C 35.0792 -9.0986
29 C1b C 36.2916 -8.3985
30 C1a C 35.0794 -10.5000
31 C1a C 37.4808 -9.0853
32 O2x O 14.7793 -7.7630
33 C1z C 13.4350 -8.1998
34 O2x O 13.4349 -9.6132
35 C1x C 14.7792 -10.0501
36 C8y C 13.4350 -6.7998
37 C1b C 12.0350 -8.1998
38 C8x C 14.6554 -6.0952
39 C8x C 14.6555 -4.6952
40 C8y C 13.4430 -3.9952
41 C8x C 12.2226 -4.6997
42 C8y C 12.2226 -6.0997
43 X Cl 13.4431 -2.5900
44 N4y N 11.3405 -9.4027
45 X Cl 11.0350 -6.7855
46 C8x C 9.9405 -9.4027
47 N5x N 9.5079 -10.7342
48 C8x C 10.6405 -11.5571
49 N5x N 11.7731 -10.7342
BOND 55
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 3 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 7 12 1
14 10 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 16 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 2
26 19 23 1
27 6 24 1
28 24 25 1
29 26 25 1 #Up
30 20 27 2
31 21 28 1
32 28 29 1
33 28 30 1
34 29 31 1
35 26 32 1
36 32 33 1
37 33 34 1
38 34 35 1
39 26 35 1
40 33 36 1 #Down
41 33 37 1 #Up
42 36 38 2
43 38 39 1
44 39 40 2
45 40 41 1
46 41 42 2
47 36 42 1
48 40 43 1
49 37 44 1
50 42 45 1
51 44 46 1
52 46 47 2
53 47 48 1
54 48 49 2
55 44 49 1
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