KEGG   DRUG: Loratadine
Entry
D00364                      Drug                                   
Name
Loratadine (JAN/USP/INN);
Claritin (TN)
Product
  Generic
LORATADINE (Bryant Ranch Prepack)
Formula
C22H23ClN2O2
Exact mass
382.1448
Mol weight
382.8832
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 4490
ATC code: R06AX13
Product: D00364<JP/US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX13 Loratadine
      D00364  Loratadine (JAN/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00364  Loratadine (JAN/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Loratadine
    D00364  Loratadine (JAN/USP/INN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    D00364  Loratadine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D00364  Loratadine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00364  Loratadine
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D00364  Loratadine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00364  Loratadine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00364
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00364
Rx-to-OTC switch list in the USA [br08315.html]
 D00364
Rx-to-OTC switch list in Japan [br08314.html]
 D00364
Other DBs
CAS: 79794-75-5
PubChem: 7847430
ChEBI: 6538
LigandBox: D00364
NIKKAJI: J23.749C
LinkDB
KCF data

ATOM        27
            1   C1x C    14.9552  -13.2773
            2   C8y C    14.1108  -12.1647
            3   C8y C    14.4469  -10.8042
            4   C2y C    15.7114  -10.2245
            5   C1x C    16.3648  -13.3026
            6   C8y C    16.9683  -10.8485
            7   C8y C    17.2556  -12.2210
            8   C8x C    13.4370   -9.8331
            9   C8x C    12.0914  -10.2223
            10  C8y C    11.7553  -11.5828
            11  C8x C    12.7651  -12.5536
            12  C8x C    18.5904  -12.6593
            13  C8x C    19.6375  -11.7223
            14  C8x C    19.3504  -10.3498
            15  N5x N    18.0153   -9.9115
            16  C2y C    15.6631   -8.8458
            17  X   Cl   10.4237  -11.9675
            18  C1x C    16.8756   -8.1458
            19  C1x C    16.8756   -6.7458
            20  N1y N    15.6631   -6.0458
            21  C1x C    14.4507   -6.7458
            22  C1x C    14.4507   -8.1458
            23  C7a C    15.6628   -4.6201
            24  O6a O    14.4631   -3.9277
            25  O7a O    16.8880   -3.9123
            26  C1b C    18.0903   -4.6062
            27  C1a C    19.2739   -3.9225
BOND        30
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   10  17 1
            20   16  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   16  22 1
            26   20  23 1
            27   23  24 2
            28   23  25 1
            29   25  26 1
            30   26  27 1

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