| Entry |
|
|---|
| Name |
Loratadine (JAN/USAN/INN);
Claritin (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C22H23ClN2O2
|
|---|
| Exact mass |
382.1448
|
|---|
| Mol weight |
382.8832
|
|---|
| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A substrate
|
|---|
| Remark |
| Therapeutic category: | 4490 |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX13 Loratadine
D00364 Loratadine (JAN/USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
449 Miscellaneous
4490 Miscellaneous
D00364 Loratadine (JAN/USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Loratadine
D00364 Loratadine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00364 Loratadine (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
Anti-allergic agents
D00364
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00364
Rx-to-OTC switch list in the USA [br08315.html]
D00364
Rx-to-OTC switch list in Japan [br08314.html]
D00364
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| Other DBs |
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| LinkDB |
 |
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| KCF data |
ATOM 27
1 C1x C 14.9552 -13.2773
2 C8y C 14.1108 -12.1647
3 C8y C 14.4469 -10.8042
4 C2y C 15.7114 -10.2245
5 C1x C 16.3648 -13.3026
6 C8y C 16.9683 -10.8485
7 C8y C 17.2556 -12.2210
8 C8x C 13.4370 -9.8331
9 C8x C 12.0914 -10.2223
10 C8y C 11.7553 -11.5828
11 C8x C 12.7651 -12.5536
12 C8x C 18.5904 -12.6593
13 C8x C 19.6375 -11.7223
14 C8x C 19.3504 -10.3498
15 N5x N 18.0153 -9.9115
16 C2y C 15.6631 -8.8458
17 X Cl 10.4237 -11.9675
18 C1x C 16.8756 -8.1458
19 C1x C 16.8756 -6.7458
20 N1y N 15.6631 -6.0458
21 C1x C 14.4507 -6.7458
22 C1x C 14.4507 -8.1458
23 C7a C 15.6628 -4.6201
24 O6a O 14.4631 -3.9277
25 O7a O 16.8880 -3.9123
26 C1b C 18.0903 -4.6062
27 C1a C 19.2739 -3.9225
BOND 30
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 10 17 1
20 16 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 16 22 1
26 20 23 1
27 23 24 2
28 23 25 1
29 25 26 1
30 26 27 1
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