KEGG   DRUG: TriamcinoloneHelp
Entry
D00385                      Drug                                   

Name
Triamcinolone (JP17/USP/INN);
Aristocort (TN);
Kenacort (TN)
Formula
C21H27FO6
Exact mass
394.1792
Mol weight
394.4339
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2454
ATC code: A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05
Chemical structure group: DG00010
Product (DG00010): D00385<JP> D00983<JP/US> D00985<US>
Efficacy
Antiasthmatic, Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC01 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA12 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB09 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB02 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB08 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD11 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA06 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA05 Triamcinolone
      D00385  Triamcinolone (JP17/USP/INN) <JP>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Triamcinolone
   D00385  Triamcinolone (JP17/USP/INN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Triamcinolone
   D00385  Triamcinolone (JP17/USP/INN)
  Triamcinolone
   D00385  Triamcinolone (JP17/USP/INN)
  Triamcinolone
   D00385  Triamcinolone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Triamcinolone
    D00385  Triamcinolone (JP17/USP/INN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Triamcinolone
    D00385  Triamcinolone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00385  Triamcinolone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00385  Triamcinolone (JP17/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00385  Triamcinolone
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D00385
BRITE hierarchy
Other DBs
CAS: 124-94-7
PubChem: 7847451
ChEBI: 9667
ChEMBL: CHEMBL1451
DrugBank: DB00620
LigandBox: D00385
NIKKAJI: J2.508I
LinkDB All DBs
KCF data Show

ATOM        28
            1   C2x C    14.0000  -26.6700
            2   C5x C    14.0000  -28.0700
            3   C2x C    15.2124  -28.7700
            4   C2y C    16.4249  -28.0700
            5   C1z C    16.4249  -26.6700
            6   C2x C    15.2124  -25.9700
            7   C1x C    17.6373  -28.7700
            8   C1x C    18.8497  -28.0700
            9   C1y C    18.8497  -26.6700
            10  C1z C    17.6373  -25.9700
            11  C1y C    20.0622  -25.9700
            12  C1z C    20.0622  -24.5700
            13  C1x C    18.8497  -23.8700
            14  C1y C    17.6373  -24.5700
            15  C1x C    22.4870  -25.9700
            16  C1y C    22.4870  -24.5700
            17  C1z C    21.2746  -23.8700
            18  O5x O    12.7876  -28.7700
            19  C1a C    16.4249  -25.2700
            20  X   F    17.6373  -27.3700
            21  O1a O    16.4269  -23.8712
            22  C1a C    20.0622  -23.1700
            23  C5a C    21.2746  -22.1900
            24  O1a O    22.6970  -22.9600
            25  O1a O    23.6866  -23.8773
            26  O5a O    22.4911  -21.4877
            27  C1b C    20.0662  -21.4923
            28  O1a O    18.8727  -22.1816
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   16  25 1 #Down
            29   23  26 2
            30   23  27 1
            31   27  28 1

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