KEGG   DRUG: Triamcinolone acetonide
Entry
D00983                      Drug                                   

Name
Triamcinolone acetonide (JP17/USP);
Azmacort (TN);
Kenalog (TN);
Nasacort (TN)
Product
  Generic
TRIAMCINOLONE ACETONIDE (A-S Medication Solutions), TRIAMCINOLONE ACETONIDE (A-S Medication Solutions), TRIAMCINOLONE ACETONIDE (Amneal Pharmaceuticals LLC), TRIAMCINOLONE ACETONIDE (Amneal Pharmaceuticals LLC), TRIAMCINOLONE ACETONIDE (Amneal Pharmaceuticals LLC), TRIAMCINOLONE ACETONIDE (Artesa Labs), TRIAMCINOLONE ACETONIDE (Ascend Laboratories), TRIAMCINOLONE ACETONIDE (Ascend Laboratories), TRIAMCINOLONE ACETONIDE (AvKARE), TRIAMCINOLONE ACETONIDE (Cintex Services), TRIAMCINOLONE ACETONIDE (Cosette Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Cosette Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Cosette Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Cosette Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Cosette Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Cosette Pharmaceuticals), TRIDERM (Crown Laboratories), TRIAMCINOLONE ACETONIDE (DIRECT RX), TRIAMCINOLONE ACETONIDE (DIRECTRX), TRIAMCINOLONE ACETONIDE (Direct_Rx), TRIAMCINOLONE ACETONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), TRIAMCINOLONE ACETONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Glenmark Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Glenmark Pharmaceuticals), TRIAMCINOLONE ACETONIDE (INA Pharmaceutics), PROTHERIX (IT3 Medical LLC), TRIAMCINOLONE ACETONIDE (Lake Erie Medical DBA Quality Care Products LLC), TRIAMCINOLONE ACETONIDE (Lake Erie Medical DBA Quality Care Products LLC), TRIAMCINOLONE ACETONIDE (Lake Erie Medical DBA Quality Care Products LLC), TRIAMCINOLONE ACETONIDE (Macleods Pharmaceuticals Limited), TRIAMCINOLONE ACETONIDE (Macleods Pharmaceuticals Limited), TRIAMCINOLONE ACETONIDE (Mayne Pharma), TRIAMCINOLONE ACETONIDE (Morton Grove Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Morton Grove Pharmaceuticals), TRIAMCINOLONE ACETONIDE (NorthStar Rx LLC), TRIAMCINOLONE ACETONIDE (Novel Laboratories), TRIAMCINOLONE ACETONIDE (NuCare Pharmaceuticals), TRIAMCINOLONE ACETONIDE (NuCare Pharmaceuticals), TRIAMCINOLONE ACETONIDE (NuCare Pharmaceuticals), TRIAMCINOLONE ACETONIDE (NuCare Pharmaceuticals), TRIAMCINOLONE ACETONIDE (NuCare Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Perrigo New York), TRIAMCINOLONE ACETONIDE (Perrigo New York), TRIAMCINOLONE ACETONIDE (Perrigo New York), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Preferred Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (Proficient Rx LP), TRIAMCINOLONE ACETONIDE (QUAGEN PHARMACEUTICALS LLC), TRIAMCINOLONE ACETONIDE (REMEDYREPACK), TRIAMCINOLONE ACETONIDE (RPK Pharmaceuticals), TRIAMCINOLONE ACETONIDE (RPK Pharmaceuticals), TRIAMCINOLONE ACETONIDE (RPK Pharmaceuticals), TRIAMCINOLONE ACETONIDE (RPK Pharmaceuticals), TRIAMCINOLONE ACETONIDE (RPK Pharmaceuticals), TRIAMCINOLONE ACETONIDE (RPK Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Rising Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Rising Pharmaceuticals), TRIAMCINOLONE ACETONIDE (Strides Pharma Science Limited), TRIAMCINOLONE ACETONIDE (Strides Pharma Science Limited), TRIAMCINOLONE ACETONIDE (Taro Pharmaceuticals U.S.A.), ORALONE (Taro Pharmaceuticals U.S.A.), TRIAMCINOLONE ACETONIDE (Taro Pharmaceuticals U.S.A.), TRIAMCINOLONE ACETONIDE (Taro Pharmaceuticals U.S.A.), TRIAMCINOLONE ACETONIDE (Teligent Pharma), TRIAMCINOLONE ACETONIDE (Teligent Pharma), TRIAMCINOLONE ACETONIDE (Teligent Pharma), TRIAMCINOLONE ACETONIDE (Teligent Pharma), TRIAMCINOLONE ACETONIDE (Teligent Pharma), TRIAMCINOLONE ACETONIDE (Teva Parenteral Medicines), TRIAMCINOLONE ACETONIDE (Versapharm Incorporated), TRIAMCINOLONE ACETONIDE (Versapharm Incorporated), TRIAMCINOLONE ACETONIDE (medsource pharmaceuticals), TRIAMCINOLONE ACETONIDE (Encube Ethicals Private Limited), SCARZEN (Village Pharma LLC)
Formula
C24H31FO6
Exact mass
434.2105
Mol weight
434.4977
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C08183
Therapeutic category: 1319 2399 2454 2646 2649
ATC code: A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05
Chemical structure group: DG00010
Product (DG00010): D00385<JP> D00983<JP/US>
Product (mixture): D10299<US>
Efficacy
Antiasthmatic, Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Perennial or seasonal allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Primary adrenocortical insufficiency [DS:H01598]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Thrombocytopenia [DS:H00978]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Nephrotic syndrome [DS:H01657]
Pulmonary tuberculosis [DS:H00342]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC01 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA12 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB09 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB02 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB08 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD11 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA06 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA05 Triamcinolone
      D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Triamcinolone
   D00983  Triamcinolone acetonide (JP17/USP)
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Triamcinolone
     D00983  Triamcinolone acetonide (JP17/USP)
   Glucocorticoids, High Potency
    Triamcinolone
     D00983  Triamcinolone acetonide (JP17/USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Triamcinolone
   D00983  Triamcinolone acetonide (JP17/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Triamcinolone
    D00983  Triamcinolone acetonide (JP17/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Triamcinolone
     D00983  Triamcinolone acetonide (JP17/USP)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Triamcinolone
    D00983  Triamcinolone acetonide (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00983  Triamcinolone acetonide (JP17/USP)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00983  Triamcinolone acetonide (JP17/USP)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00983  Triamcinolone acetonide (JP17/USP)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00983  Triamcinolone acetonide (JP17/USP)
    2649  Others
     D00983  Triamcinolone acetonide (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for dental and stomatological use
  74 Stomatitis remedies
   D00983  Triamcinolone acetonide (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Triamcinolone acetonide
    D00983  Triamcinolone acetonide (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Triamcinolone acetonide
    D00983  Triamcinolone acetonide (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00983  Triamcinolone acetonide (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00983  Triamcinolone acetonide
Topical steroids potency [br08317.html]
 Classification in the USA
  D00983
 Classification in Japan
  D00983
Rx-to-OTC switch list in the USA [br08315.html]
 D00983
Rx-to-OTC switch list in Japan [br08314.html]
 D00983
Other DBs
CAS: 76-25-5
PubChem: 7848046
ChEBI: 71418
ChEMBL: CHEMBL1504 CHEMBL275338
DrugBank: DB00620
PDB-CCD: 1TA[PDBj]
LigandBox: D00983
NIKKAJI: J55.714E
LinkDB
KCF data

ATOM        31
            1   C2x C    18.6900  -28.5600
            2   C5x C    18.6900  -29.8900
            3   C2x C    19.8800  -30.5900
            4   C2y C    21.0700  -29.8900
            5   C1z C    21.0700  -28.5600
            6   C2x C    19.8800  -27.8600
            7   C1x C    22.2600  -30.5900
            8   C1x C    23.4500  -29.8900
            9   C1y C    23.4500  -28.5600
            10  C1z C    22.2600  -27.8600
            11  C1y C    24.5700  -27.8600
            12  C1z C    24.5700  -26.5300
            13  C1x C    23.4500  -25.8300
            14  C1y C    22.2600  -26.5300
            15  C1x C    26.9500  -27.8600
            16  C1y C    26.9500  -26.5300
            17  C1z C    25.7600  -25.8300
            18  O5x O    17.5700  -30.5900
            19  C1a C    21.0700  -27.1600
            20  X   F    22.2600  -29.1900
            21  O1a O    21.0700  -25.8300
            22  C1a C    24.5700  -25.1300
            23  C5a C    25.7600  -24.2200
            24  O2x O    27.1600  -24.9200
            25  O5a O    26.9500  -23.5200
            26  C1b C    24.5700  -23.5200
            27  O1a O    23.4500  -24.2200
            28  O2x O    28.3500  -26.5300
            29  C1z C    28.5600  -24.9200
            30  C1a C    29.9600  -24.9200
            31  C1a C    28.5600  -23.5200
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   23  25 2
            29   23  26 1
            30   26  27 1
            31   16  28 1 #Down
            32   24  29 1
            33   29  28 1
            34   29  30 1
            35   29  31 1

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