| Entry |
|
|---|
| Name |
Troglitazone (JAN/USAN/INN);
Rezulin (TN) |
|---|
| Formula |
C24H27NO5S
|
|---|
| Exact mass |
441.161
|
|---|
| Mol weight |
441.5399
|
|---|
| Structure |
|
|---|
| Class |
|
|---|
| Remark |
|
|---|
| Efficacy |
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist |
|---|
| Comment |
hepatotoxicity
Thiazolidinedione derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07222 | Peroxisome proliferator-activated receptor (PPAR) agonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BG Thiazolidinediones
A10BG01 Troglitazone
D00395 Troglitazone (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C3 (PPARG)
D00395 Troglitazone (JAN/USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00395
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 31
1 C8y C 14.4237 -16.8030
2 C8y C 14.4237 -18.2037
3 C8y C 15.6367 -18.9040
4 C8y C 16.8497 -18.2037
5 C8y C 16.8497 -16.8030
6 C8y C 15.6367 -16.1027
7 C1x C 18.0627 -18.9040
8 C1x C 19.2757 -18.2037
9 C1z C 19.2757 -16.8030
10 O2x O 18.0627 -16.1027
11 O2a O 21.7017 -16.8030
12 C1b C 20.4887 -16.1027
13 C8y C 22.9147 -16.1027
14 C8x C 22.9147 -14.7020
15 C8x C 24.1277 -16.8030
16 C8x C 25.3407 -16.1027
17 C8y C 25.3407 -14.7020
18 C8x C 24.1277 -14.0017
19 O5x O 26.5538 -16.8030
20 C5x C 27.7668 -16.1027
21 C1y C 27.7668 -14.7020
22 C1b C 26.5538 -14.0017
23 N1x N 29.0989 -16.5355
24 C5x C 29.9222 -15.4024
25 S2x S 29.0989 -14.2692
26 C1a C 15.6367 -14.7022
27 C1a C 13.2107 -16.1027
28 O1a O 13.2107 -18.9040
29 C1a C 15.6367 -20.3045
30 O5x O 31.3016 -15.4024
31 C1a C 20.4881 -17.5030
BOND 34
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 11 12 1
13 9 12 1
14 11 13 1
15 13 14 2
16 13 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 14 18 1
21 19 20 2
22 20 21 1
23 21 22 1
24 17 22 1
25 20 23 1
26 23 24 1
27 24 25 1
28 21 25 1
29 6 26 1
30 1 27 1
31 2 28 1
32 3 29 1
33 24 30 2
34 9 31 1
|
|---|
