KEGG   DRUG: Zidovudine
Entry
D00413                      Drug                                   
Name
Zidovudine (JP18/USP/INN);
Azidothymidine;
Retrovir (TN)
  Abbr
AZT, ZDV
Product
  Generic
Formula
C10H13N5O4
Exact mass
267.0968
Mol weight
267.2413
Structure
Simcomp
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
 DG02859  SLC22A6 substrate
 DG02860  SLC22A8 substrate
Remark
Same as: C07210
Therapeutic category: 6250
ATC code: J05AF01
Product: D00413<JP/US>
Product (mixture): D07507<JP/US> D10838<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Target
HIV-1 reverse transcriptase [KO:K24802]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
Structure map
map07044  Antiviral agents
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF01 Zidovudine
      D00413  Zidovudine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
   Zidovudine
    D00413  Zidovudine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00413  Zidovudine (JP18/USP/INN)
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   D00413  Zidovudine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D00413  Zidovudine
 Transporter substrate
  DG02859  SLC22A6 substrate
   D00413  Zidovudine
  DG02860  SLC22A8 substrate
   D00413  Zidovudine
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D00413  Zidovudine
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D00413  Zidovudine (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D00413  Zidovudine (JP18/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00413  Zidovudine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00413
Other DBs
CAS: 30516-87-1
PubChem: 7847479
ChEBI: 10110
PDB-CCD: AZZ[PDBj]
LigandBox: D00413
NIKKAJI: J20.566D
LinkDB
KCF data

ATOM        19
            1   C1y C    18.8657  -16.2961
            2   N4y N    20.5359  -15.5648
            3   C1x C    18.4295  -17.5962
            4   O2x O    17.7601  -15.4854
            5   C8y C    21.6329  -16.2525
            6   C8x C    20.4803  -14.1952
            7   C1y C    17.0654  -17.5917
            8   C1y C    16.6491  -16.2888
            9   N4x N    22.8245  -15.5863
            10  O5x O    21.6194  -17.6179
            11  C8y C    21.6659  -13.5204
            12  N2b N    16.2659  -18.6975
            13  C1b C    15.3431  -15.8696
            14  C8y C    22.8512  -14.2198
            15  C1a C    21.6815  -12.1564
            16  O1a O    14.3229  -16.7755
            17  O5x O    24.0708  -13.6122
            18  N0  N    15.3644  -19.7657 #+
            19  N2a N    14.3822  -20.9233 #-
BOND        20
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1 #Down
            12    8  13 1 #Up
            13    9  14 1
            14   11  15 1
            15   13  16 1
            16   14  17 2
            17    7   8 1
            18   11  14 1
            19   12  18 2
            20   18  19 2

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