| Entry |
|
|---|
| Name |
Zidovudine (JP18/USP/INN);
Azidothymidine;
Retrovir (TN) |
|---|
| Abbr |
AZT, ZDV |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C10H13N5O4
|
|---|
| Exact mass |
267.0968
|
|---|
| Mol weight |
267.24
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
Transporter substrate
DG02859 SLC22A6 substrate
DG02860 SLC22A8 substrate
|
|---|
| Remark |
| Therapeutic category: | 6250 |
| Product (mixture): | D07507<JP/US> D10838<US> |
|
|---|
| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
|---|
| Disease |
|
|---|
| Target |
HIV-1 reverse transcriptase [KO: K24802] |
|---|
| Pathway |
| ko03260 | Virion - Human immunodeficiency virus |
|
|---|
| Metabolism |
Transporter: SLC22A6 [HSA: 9356], SLC22A8 [HSA: 9376]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF01 Zidovudine
D00413 Zidovudine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
Zidovudine
D00413 Zidovudine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D00413 Zidovudine (JP18/USP/INN)
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
D00413 Zidovudine
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
D00413 Zidovudine
Transporter substrate
DG02859 SLC22A6 substrate
D00413 Zidovudine
DG02860 SLC22A8 substrate
D00413 Zidovudine
Drug classes [BR:br08332]
Antiviral
DG03107 Anti-HIV agent
D00413 Zidovudine
Antimicrobials [BR:br08307]
Antivirals
Genome replication inhibitor
HIV reverse transcriptase inhibitor
D00413 Zidovudine (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
Genome replication inhibitor
HIV reverse transcriptase inhibitor
D00413 Zidovudine (JP18/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00413 Zidovudine
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D00413
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 19
1 C1y C 18.8657 -16.2961
2 N4y N 20.5359 -15.5648
3 C1x C 18.4295 -17.5962
4 O2x O 17.7601 -15.4854
5 C8y C 21.6329 -16.2525
6 C8x C 20.4803 -14.1952
7 C1y C 17.0654 -17.5917
8 C1y C 16.6491 -16.2888
9 N4x N 22.8245 -15.5863
10 O5x O 21.6194 -17.6179
11 C8y C 21.6659 -13.5204
12 N2b N 16.2659 -18.6975
13 C1b C 15.3431 -15.8696
14 C8y C 22.8512 -14.2198
15 C1a C 21.6815 -12.1564
16 O1a O 14.3229 -16.7755
17 O5x O 24.0708 -13.6122
18 N0 N 15.3644 -19.7657 #+
19 N2a N 14.3822 -20.9233 #-
BOND 20
1 1 2 1 #Up
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 4 8 1
8 5 9 1
9 5 10 2
10 6 11 2
11 7 12 1 #Down
12 8 13 1 #Up
13 9 14 1
14 11 15 1
15 13 16 1
16 14 17 2
17 7 8 1
18 11 14 1
19 12 18 2
20 18 19 2
|
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