KEGG   DRUG: ZidovudineHelp
Entry
D00413                      Drug                                   

Name
Zidovudine (JP17/USP/INN);
Retrovir (TN)
Product
  Generic
Formula
C10H13N5O4
Exact mass
267.0968
Mol weight
267.2413
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG01656  HIV reverse transcriptase inhibitor
Unclassified
 DG02859  SLC22A6 (OAT1) substrate
 DG02860  SLC22A8 (OAT3) substrate
Remark
Same as: C07210
Therapeutic category: 6250
ATC code: J05AF01
Product: D00413<JP/US>
Product (mixture): D07507<JP/US> D10838<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Target
RNA-directed DNA polymerase
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
Drug interaction
Structure map
map07044  Antiviral agents
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF01 Zidovudine
      D00413  Zidovudine (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Zidovudine
    D00413  Zidovudine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00413  Zidovudine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00413  Zidovudine
Antiinfectives [br08350.html]
 Antivirals
  D00413
BRITE hierarchy
Other DBs
CAS: 30516-87-1
PubChem: 7847479
ChEBI: 10110
ChEMBL: CHEMBL129
DrugBank: DB00495
PDB-CCD: AZZ[PDBj]
LigandBox: D00413
NIKKAJI: J20.566D
LinkDB All DBs
KCF data Show

ATOM        19
            1   C1y C    18.8657  -16.2961
            2   N4y N    20.5359  -15.5648
            3   C1x C    18.4295  -17.5962
            4   O2x O    17.7601  -15.4854
            5   C8y C    21.6329  -16.2525
            6   C8x C    20.4803  -14.1952
            7   C1y C    17.0654  -17.5917
            8   C1y C    16.6491  -16.2888
            9   N4x N    22.8245  -15.5863
            10  O5x O    21.6194  -17.6179
            11  C8y C    21.6659  -13.5204
            12  N2b N    16.2659  -18.6975
            13  C1b C    15.3431  -15.8696
            14  C8y C    22.8512  -14.2198
            15  C1a C    21.6815  -12.1564
            16  O1a O    14.3229  -16.7755
            17  O5x O    24.0708  -13.6122
            18  N0  N    15.3644  -19.7657 #+
            19  N2a N    14.3822  -20.9233 #-
BOND        20
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1 #Down
            12    8  13 1 #Up
            13    9  14 1
            14   11  15 1
            15   13  16 1
            16   14  17 2
            17    7   8 1
            18   11  14 1
            19   12  18 2
            20   18  19 2

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