KEGG   DRUG: Pyridostigmine bromideHelp
Entry
D00487                      Drug                                   

Name
Pyridostigmine bromide (JP17/USP/INN);
Mestinon (TN)
Product
  Generic
Formula
C9H13N2O2. Br
Exact mass
260.016
Mol weight
261.1157
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Other
 DG01719  Parasympathomimetic agent
Remark
Therapeutic category: 1233
ATC code: N07AA02
Chemical structure group: DG00988
Product (DG00988): D00487<JP/US>
Efficacy
Acetylcholinesterase inhibitor
  Disease
Myasthenia gravis [DS:H01594]
Comment
Physostigmine derivative
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA02 Pyridostigmine
      D00487  Pyridostigmine bromide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antimyasthenic Agents
  Parasympathomimetics
   Pyridostigmine
    D00487  Pyridostigmine bromide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1233  Neostigmines
     D00487  Pyridostigmine bromide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D00487  Pyridostigmine bromide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00487  Pyridostigmine bromide
BRITE hierarchy
Other DBs
CAS: 101-26-8
PubChem: 7847553
ChEBI: 8666
ChEMBL: CHEMBL812
DrugBank: DB00545
LigandBox: D00487
NIKKAJI: J252.883E
LinkDB All DBs
KCF data Show

ATOM        14
            1   C8y C    22.7500  -20.9300
            2   O7a O    21.4900  -20.2300
            3   C8x C    22.7500  -22.3300
            4   C8x C    23.9400  -20.2300
            5   C7a C    20.3000  -20.9300
            6   N5y N    23.9400  -23.0300 #+
            7   C8x C    25.1300  -20.9300
            8   N1c N    19.1100  -20.2300
            9   O6a O    20.3000  -22.3300
            10  C8x C    25.1300  -22.3300
            11  C1a C    23.9400  -24.4300
            12  C1a C    17.8500  -20.9300
            13  C1a C    19.1100  -18.8300
            14  X   Br   26.6700  -23.1700 #-
BOND        13
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 1
            8     5   9 2
            9     6  10 1
            10    6  11 1
            11    8  12 1
            12    8  13 1
            13    7  10 2

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