Homo sapiens (human): 43
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Entry
43 CDS
T01001
Symbol
ACHE, ACEE, ARACHE, N-ACHE, YT
Name
(RefSeq) acetylcholinesterase (Yt blood group)
KO
K01049
acetylcholinesterase [EC:
3.1.1.7
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00564
Glycerophospholipid metabolism
hsa04082
Neuroactive ligand signaling
hsa04725
Cholinergic synapse
Network
nt06544
Neuroactive ligand signaling
Element
N01896
Acetylcholine metabolism and transport in neuron
Drug target
Acotiamide:
D08838
<JP>
Ambenonium (
DG00990
):
D01001
<JP>
Benzgalantamine (
DG03314
):
D12930
D12931
<US>
Buntanetap (
DG03220
):
D12318
D12319
Demecarium:
D00667
Dimetacrine:
D02565
Distigmine (
DG00989
):
D01228
<JP>
Donepezil (
DG00983
):
D00670
<JP/US>
D07869
<JP>
Ecothiopate (
DG01131
):
D02193
<US>
Edrophonium:
D00994
<JP>
Fluostigmine:
D00043
Galantamine (
DG00985
):
D02173
<JP/US>
D04292
Gallamine:
D02292
Icopezil maleate:
D03751
Ipidacrine:
D09750
Itopride (
DG01395
):
D02729
<JP>
D08094
Ladostigil tartrate:
D03239
Latrepirdine (
DG01379
):
D09917
D09918
Neostigmine (
DG00987
):
D00995
<JP>
D00998
<JP/US>
D08261
Obidoxime:
D05215
Paraoxon:
D10529
Physostigmine (
DG01132
):
D00196
D02418
D03826
Pralidoxime (
DG01153
):
D00469
<US>
D01572
<JP>
D05590
Pyridostigmine (
DG00988
):
D00487
<JP/US>
Quilostigmine:
D03823
Rivastigmine (
DG00984
):
D02558
<US>
D03822
<JP/US>
Suronacrine maleate:
D05981
Tacrine (
DG00982
):
D02068
D08555
Velnacrine maleate:
D06288
Zanapezil fumarate:
D09835
Zifrosilone:
D06365
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00564 Glycerophospholipid metabolism
43 (ACHE)
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
43 (ACHE)
09150 Organismal Systems
09156 Nervous system
04725 Cholinergic synapse
43 (ACHE)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:
hsa00537
]
43 (ACHE)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.7 acetylcholinesterase
43 (ACHE)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:
hsa00537
]
Enzymes
43 (ACHE)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
COesterase
AChE_tetra
BD-FAE
Abhydrolase_3
Motif
Other DBs
NCBI-GeneID:
43
NCBI-ProteinID:
NP_000656
OMIM:
100740
HGNC:
108
Ensembl:
ENSG00000087085
UniProt:
P22303
Structure
PDB
PDBj
LinkDB
All DBs
Position
7:complement(100889994..100896994)
Genome browser
AA seq
614 aa
AA seq
DB search
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
NT seq
1845 nt
NT seq
+upstream
nt +downstream
nt
atgaggcccccgcagtgtctgctgcacacgccttccctggcttccccactccttctcctc
ctcctctggctcctgggtggaggagtgggggctgagggccgggaggatgcagagctgctg
gtgacggtgcgtgggggccggctgcggggcattcgcctgaagacccccgggggccctgtc
tctgctttcctgggcatcccctttgcggagccacccatgggaccccgtcgctttctgcca
ccggagcccaagcagccttggtcaggggtggtagacgctacaaccttccagagtgtctgc
taccaatatgtggacaccctatacccaggttttgagggcaccgagatgtggaaccccaac
cgtgagctgagcgaggactgcctgtacctcaacgtgtggacaccatacccccggcctaca
tcccccacccctgtcctcgtctggatctatgggggtggcttctacagtggggcctcctcc
ttggacgtgtacgatggccgcttcttggtacaggccgagaggactgtgctggtgtccatg
aactaccgggtgggagcctttggcttcctggccctgccggggagccgagaggccccgggc
aatgtgggtctcctggatcagaggctggccctgcagtgggtgcaggagaacgtggcagcc
ttcgggggtgacccgacatcagtgacgctgtttggggagagcgcgggagccgcctcggtg
ggcatgcacctgctgtccccgcccagccggggcctgttccacagggccgtgctgcagagc
ggtgcccccaatggaccctgggccacggtgggcatgggagaggcccgtcgcagggccacg
cagctggcccaccttgtgggctgtcctccaggcggcactggtgggaatgacacagagctg
gtagcctgccttcggacacgaccagcgcaggtcctggtgaaccacgaatggcacgtgctg
cctcaagaaagcgtcttccggttctccttcgtgcctgtggtagatggagacttcctcagt
gacaccccagaggccctcatcaacgcgggagacttccacggcctgcaggtgctggtgggt
gtggtgaaggatgagggctcgtattttctggtttacggggccccaggcttcagcaaagac
aacgagtctctcatcagccgggccgagttcctggccggggtgcgggtcggggttccccag
gtaagtgacctggcagccgaggctgtggtcctgcattacacagactggctgcatcccgag
gacccggcacgcctgagggaggccctgagcgatgtggtgggcgaccacaatgtcgtgtgc
cccgtggcccagctggctgggcgactggctgcccagggtgcccgggtctacgcctacgtc
tttgaacaccgtgcttccacgctctcctggcccctgtggatgggggtgccccacggctac
gagatcgagttcatctttgggatccccctggacccctctcgaaactacacggcagaggag
aaaatcttcgcccagcgactgatgcgatactgggccaactttgcccgcacaggggatccc
aatgagccccgagaccccaaggccccacaatggcccccgtacacggcgggggctcagcag
tacgttagtctggacctgcggccgctggaggtgcggcgggggctgcgcgcccaggcctgc
gccttctggaaccgcttcctccccaaattgctcagcgccaccgacacgctcgacgaggcg
gagcgccagtggaaggccgagttccaccgctggagctcctacatggtgcactggaagaac
cagttcgaccactacagcaagcaggatcgctgctcagacctgtga
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integrated database retrieval system