 | | DRUG: Phenylephrine hydrochloride | |
| Entry |
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| Name |
Phenylephrine hydrochloride (JP18/USP);
Neo-synephrine (TN) |
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| Product |
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| Generic |
PHENYLEPHRINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), PHENYLEPHRINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), PHENYLEPHRINE HYDROCHLORIDE (Armas Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (BE Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (Bausch & Lomb Americas), PHENYLEPHRINE HYDROCHLORIDE (Camber Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (Caplin Steriles Limited), PHENYLEPHRINE HYDROCHLORIDE (Caplin Steriles Limited), PHENYLEPHRINE HYDROCHLORIDE (Cardinal Health 107), PHENYLEPHRINE HYDROCHLORIDE (Dr.Reddy's Laboratories Inc.,), PHENYLEPHRINE HYDROCHLORIDE (Endo USA), PHENYLEPHRINE HYDROCHLORIDE (Eugia US LLC), PHENYLEPHRINE HYDROCHLORIDE (Eugia US LLC), PHENYLEPHRINE HYDROCHLORIDE (Fresenius Kabi USA), PHENYLEPHRINE HYDROCHLORIDE (Fresenius Kabi USA), PHENYLEPHRINE HYDROCHLORIDE (Fresenius Kabi USA), PHENYLEPHRINE HYDROCHLORIDE (Gland Pharma Limited), PHENYLEPHRINE HYDROCHLORIDE (Gland Pharma Limited), PHENYLEPHRINE HYDROCHLORIDE (HF Acquisition Co LLC), PHENYLEPHRINE HYDROCHLORIDE (Hainan Poly Pharm.), PHENYLEPHRINE HYDROCHLORIDE (Henry Schein), PHENYLEPHRINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (Leading Pharma), PHENYLEPHRINE HYDROCHLORIDE (Lifestar Pharma LLC), PHENYLEPHRINE HYDROCHLORIDE (Lifestar Pharma LLC), PHENYLEPHRINE HYDROCHLORIDE (Lifestar Pharma LLC), PHENYLEPHRINE HYDROCHLORIDE (Medical Purchasing Solutions), PHENYLEPHRINE HYDROCHLORIDE (Medical Purchasing Solutions), PHENYLEPHRINE HYDROCHLORIDE (Medical Purchasing Solutions), PHENYLEPHRINE HYDROCHLORIDE (Medical Purchasing Solutions), PHENYLEPHRINE HYDROCHLORIDE (Medical Purhasing Solutions), PHENYLEPHRINE HYDROCHLORIDE (Meitheal Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (Meitheal Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (NorthStar RxLLC), PHENYLEPHRINE HYDROCHLORIDE (NorthStar RxLLC), PHENYLEPHRINE HYDROCHLORIDE (Novadoz Pharmaceuticals LLC), PHENYLEPHRINE HYDROCHLORIDE (Provepharm), PHENYLEPHRINE HYDROCHLORIDE (SOLA Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (Sagent Pharmaceuticals), PHENYLEPHRINE HYDROCHLORIDE (Sandoz), PHENYLEPHRINE HYDROCHLORIDE (Sandoz), PHENYLEPHRINE HYDROCHLORIDE (Somerset Therapeutics), PHENYLEPHRINE HYDROCHLORIDE (Somerset Therapeutics), PHENYLEPHRINE HYDROCHLORIDE (Somerset Therapeutics), PHENYLEPHRINE HYDROCHLORIDE (Xellia Pharmaceuticals USA LLC) |
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| Formula |
C9H13NO2. HCl
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| Exact mass |
203.0713
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| Mol weight |
203.66
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
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| Remark |
| Product (DG00215): | D00511<JP/US> |
| Product (mixture): | D04081<JP> D10837<US> D11698<US> D11853<US> D12138<US> |
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| Efficacy |
Antihypotensive, Midriatic, Vasoconstrictor, alpha1-Adrenergic receptor agonist |
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| Comment |
Phenethylamine derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
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| Interaction |
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| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA06 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AX Other agents for treatment of hemorrhoids and anal fissures for topical use
C05AX06 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AA Sympathomimetics, plain
R01AA04 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
R01AB Sympathomimetics, combinations excl. corticosteroids
R01AB01 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
R01B NASAL DECONGESTANTS FOR SYSTEMIC USE
R01BA Sympathomimetics
R01BA03 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01F MYDRIATICS AND CYCLOPLEGICS
S01FB Sympathomimetics excl. antiglaucoma preparations
S01FB01 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA05 Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Alpha-adrenergic Agonists
Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP)
Ophthalmic Agents
Ophthalmic Agents, Other
Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1311 Mydriatic agents
D00511 Phenylephrine hydrochloride (JP18/USP)
2 Agents affecting individual organs
21 Cardiovascular agents
216 Vasoconstrictors
2160 Vasoconstrictors
D00511 Phenylephrine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Phenylephrine
D00511 Phenylephrine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG00215 Phenylephrine
D00511 Phenylephrine hydrochloride
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG00215 Phenylephrine
D00511 Phenylephrine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00511 Phenylephrine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00511 Phenylephrine hydrochloride
Rx-to-OTC switch list in the USA [br08315.html]
D00511
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG00215 Phenylephrine
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG00215 Phenylephrine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 13
1 X Cl 25.9001 -19.1101
2 C8y C 18.0600 -16.7300
3 C8x C 18.0600 -18.1300
4 C8x C 19.2500 -18.8300
5 C8x C 20.4400 -18.1300
6 C8y C 20.4400 -16.7300
7 C8x C 19.2500 -16.0300
8 O1a O 16.8000 -16.0300
9 C1c C 21.7000 -16.0300
10 C1b C 22.8900 -16.7300
11 O1a O 21.7000 -14.6300
12 N1b N 24.0800 -16.0300
13 C1a C 25.2700 -16.7300
BOND 12
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 2 8 1
8 6 9 1
9 9 10 1
10 9 11 1 #Up
11 10 12 1
12 12 13 1
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