KEGG   DRUG: Phenylephrine hydrochlorideHelp
Entry
D00511                      Drug                                   

Name
Phenylephrine hydrochloride (JP17/USP);
Neo-synephrine (TN)
Product
  Generic
Formula
C9H13NO2. HCl
Exact mass
203.0713
Mol weight
203.666
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Remark
Therapeutic category: 1311 2160
ATC code: C01CA06 R01AA04 R01AB01 R01BA03 S01FB01 S01GA05
Chemical structure group: DG00215
Product (DG00215): D00511<JP/US>
Product (mixture): D04081<JP> D10837<US>
Efficacy
Antihypotensive, Midriatic, Vasoconstrictor, alpha1-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA06 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA04 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB01 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
   R01B NASAL DECONGESTANTS FOR SYSTEMIC USE
    R01BA Sympathomimetics
     R01BA03 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB01 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA05 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Phenylephrine
    D00511  Phenylephrine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D00511  Phenylephrine hydrochloride (JP17/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00511  Phenylephrine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Phenylephrine
    D00511  Phenylephrine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00511  Phenylephrine hydrochloride
Rx-to-OTC switch list in the USA [br08315.html]
 D00511
BRITE hierarchy
Other DBs
CAS: 61-76-7
PubChem: 7847577
ChEBI: 8094
ChEMBL: CHEMBL1200339
DrugBank: DB00388
LigandBox: D00511
NIKKAJI: J98.894D
LinkDB All DBs
KCF data Show

ATOM        13
            1   X   Cl   25.9001  -19.1101
            2   C8y C    18.0600  -16.7300
            3   C8x C    18.0600  -18.1300
            4   C8x C    19.2500  -18.8300
            5   C8x C    20.4400  -18.1300
            6   C8y C    20.4400  -16.7300
            7   C8x C    19.2500  -16.0300
            8   O1a O    16.8000  -16.0300
            9   C1c C    21.7000  -16.0300
            10  C1b C    22.8900  -16.7300
            11  O1a O    21.7000  -14.6300
            12  N1b N    24.0800  -16.0300
            13  C1a C    25.2700  -16.7300
BOND        12
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     6   9 1
            9     9  10 1
            10    9  11 1 #Up
            11   10  12 1
            12   12  13 1

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