KEGG   DRUG: Pilocarpine
Entry
D00525                      Drug                                   
Name
Pilocarpine (JAN/USP);
Ocusert pilo-20 (TN)
Formula
C11H16N2O2
Exact mass
208.1212
Mol weight
208.2569
Structure
Simcomp
Source
Pilocarpus [TAX:77016]
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
 DG01719  Parasympathomimetic agent
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Remark
Same as: C07474
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Antiglaucoma, Muscarinic acetylcholine receptor agonist
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D00525  Pilocarpine (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D00525  Pilocarpine (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
    D00525  Pilocarpine
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
    D00525  Pilocarpine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
    D00525  Pilocarpine
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
    D00525  Pilocarpine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D00525  Pilocarpine (JAN/USP)
    CHRM3
     D00525  Pilocarpine (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00525
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
Other DBs
CAS: 92-13-7
PubChem: 7847591
ChEBI: 8207
PDB-CCD: 9PL[PDBj]
LigandBox: D00525
NIKKAJI: J9.328I
LinkDB
KCF data

ATOM        15
            1   C1y C    24.1199  -19.7000
            2   C1y C    22.7112  -19.7000
            3   C1b C    25.3415  -20.3431
            4   C1x C    24.5641  -18.3555
            5   C7x C    22.2729  -18.3555
            6   C1b C    21.8810  -20.8399
            7   C8y C    26.4112  -19.7058
            8   O7x O    23.4185  -17.5255
            9   O6a O    20.9284  -17.9171
            10  C1a C    20.4782  -20.8338
            11  N4y N    27.8257  -19.7058
            12  C8x C    25.9670  -18.3614
            13  C8x C    28.2584  -18.3614
            14  C1a C    28.6499  -20.8456
            15  N5x N    27.1186  -17.5313
BOND        16
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2

» Japanese version   » Back

KEGG   DRUG: Pilocarpine hydrochloride
Entry
D02200                      Drug                                   
Name
Pilocarpine hydrochloride (JP18/USP);
Isopto carpine (TN);
Pilopine HS (TN);
Salagen (TN);
Sanpilo (TN)
Product
  Generic
Formula
C11H16N2O2. HCl
Exact mass
244.0979
Mol weight
244.7179
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
 DG01719  Parasympathomimetic agent
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Remark
Therapeutic category: 1312 2399
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Antiglaucoma, Miotic, Salivation accelaletor, Muscarinic acetylcholine receptor agonist
  Disease
Open-angle glaucoma [DS:H00612]
Sjogren's Syndrome [DS:H01502]
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D02200  Pilocarpine hydrochloride (JP18/USP)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Cholinergic Agonists, Ophthalmic
    Pilocarpine
     D02200  Pilocarpine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1312  Miotic agents
     D02200  Pilocarpine hydrochloride (JP18/USP)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D02200  Pilocarpine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
    D02200  Pilocarpine hydrochloride
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
    D02200  Pilocarpine hydrochloride
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
    D02200  Pilocarpine hydrochloride
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
    D02200  Pilocarpine hydrochloride
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D02200  Pilocarpine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D02200  Pilocarpine hydrochloride (JP18/USP) <JP/US>
    CHRM3
     D02200  Pilocarpine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02200  Pilocarpine hydrochloride
  D02200  Pilocarpine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02200
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
Other DBs
CAS: 54-71-7
PubChem: 7849260
LigandBox: D02200
NIKKAJI: J231.249B
LinkDB
KCF data

ATOM        16
            1   C1y C    22.9454  -19.7221
            2   C1y C    21.4986  -19.7221
            3   C1b C    24.1589  -20.3289
            4   C1x C    23.3654  -18.3687
            5   C7x C    21.0786  -18.3687
            6   C1b C    20.7052  -20.8422
            7   C8y C    25.2323  -19.7221
            8   O7x O    22.2454  -17.5286
            9   O6a O    19.7251  -17.9019
            10  C1a C    19.3051  -20.8422
            11  N4y N    26.6324  -19.7221
            12  C8x C    24.7656  -18.3687
            13  C8x C    27.0525  -18.3687
            14  C1a C    27.4725  -20.8422
            15  N5x N    25.9323  -17.5286
            16  X   Cl   29.8072  -18.8353
BOND        16
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2

» Japanese version   » Back

KEGG   DRUG: Pilocarpine nitrate
Entry
D05478                      Drug                                   
Name
Pilocarpine nitrate (USP);
Pilagan (TN)
Formula
C11H16N2O2. HNO3
Exact mass
271.1168
Mol weight
271.2698
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
 DG01719  Parasympathomimetic agent
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Remark
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Miotic, Muscarinic acetylcholine receptor agonist
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D05478  Pilocarpine nitrate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D05478  Pilocarpine nitrate (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
    D05478  Pilocarpine nitrate
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
    D05478  Pilocarpine nitrate
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
    D05478  Pilocarpine nitrate
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
    D05478  Pilocarpine nitrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D05478  Pilocarpine nitrate (USP)
    CHRM3
     D05478  Pilocarpine nitrate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05478
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
Other DBs
CAS: 148-72-1
PubChem: 47207147
LigandBox: D05478
NIKKAJI: J262.833C
LinkDB
KCF data

ATOM        19
            1   C1y C    28.6049  -17.6741
            2   C1y C    27.1960  -17.6741
            3   C1b C    29.8268  -18.3174
            4   C1x C    29.0492  -16.3294
            5   C7x C    26.7576  -16.3294
            6   C1b C    26.3656  -18.8143
            7   C8y C    30.8967  -17.6799
            8   O7x O    27.9034  -15.4992
            9   O6a O    25.4128  -15.8909
            10  C1a C    24.9625  -18.8082
            11  N4y N    32.3115  -17.6799
            12  C8x C    30.4524  -16.3353
            13  C8x C    32.7443  -16.3353
            14  C1a C    33.1359  -18.8200
            15  N5x N    31.6043  -15.5050
            16  N2b N    37.8531  -17.0458 #+
            17  O3a O    37.8472  -15.6499
            18  O3a O    39.0961  -17.7559 #-
            19  O1b O    36.6419  -17.7522
BOND        19
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2
            17   16  17 2
            18   16  18 1
            19   16  19 1

» Japanese version   » Back

KEGG   DRUG: Pilocarpine borate
Entry
D08376                      Drug                                   
Name
Pilocarpine borate;
pilolarpin ophtha (TN)
Formula
C11H16N2O2. xH3BO3
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
 DG01719  Parasympathomimetic agent
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Remark
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Miotic, Muscrinic receptor agonist
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D08376  Pilocarpine borate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D08376  Pilocarpine borate
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
    D08376  Pilocarpine borate
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
    D08376  Pilocarpine borate
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
    D08376  Pilocarpine borate
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
    D08376  Pilocarpine borate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D08376  Pilocarpine borate
    CHRM3
     D08376  Pilocarpine borate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08376
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00992  Pilocarpine
  DG01719  Parasympathomimetic agent
   DG00992  Pilocarpine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00992  Pilocarpine
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00992  Pilocarpine
Other DBs
CAS: 16509-56-1
PubChem: 96025062
LigandBox: D08376
LinkDB
KCF data

ATOM        19
            1   C1y C    18.3400  -18.5500
            2   C1y C    16.8700  -18.5500
            3   C1b C    19.5300  -19.2500
            4   C1x C    18.7600  -17.2200
            5   C7x C    16.4500  -17.2200
            6   C1b C    16.1000  -19.7400
            7   C8y C    20.5800  -18.6200
            8   O7x O    17.6400  -16.3800
            9   O6a O    15.1200  -16.8000
            10  C1a C    14.7000  -19.7400
            11  N4y N    22.0500  -18.6200
            12  C8x C    20.1600  -17.2200
            13  C8x C    22.4700  -17.2200
            14  C1a C    22.8200  -19.7400
            15  N5x N    21.2800  -16.3800
            16  Z   B    29.8900  -18.4800
            17  O1a O    29.8900  -17.0800
            18  O1a O    28.6776  -19.1800
            19  O1a O    31.1024  -19.1800
BOND        19
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2
            17   16  17 1
            18   16  18 1
            19   16  19 1
BRACKET     1    26.8800  -19.8100   26.8800  -16.0300
            1    32.9000  -16.0300   32.9000  -19.8100
            1  x
 ORIGINAL  1   16  17  18  19
 REPEAT    1

» Japanese version   » Back

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