KEGG   DRUG: DofetilideHelp
Entry
D00647                      Drug                                   

Name
Dofetilide (JAN/USAN/INN);
Tikosyn (TN)
Product
  Generic
Formula
C19H27N3O5S2
Exact mass
441.1392
Mol weight
441.5648
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01648  Class III antiarrhythmic agent
Remark
Same as: C07751
ATC code: C01BD04
Product: D00647<US>
Efficacy
Antiarrhythmic, Potassium channel blocker
Comment
Sematilide derivative
Target
KCNH2 [HSA:3757] [KO:K04905]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BD Antiarrhythmics, class III
     C01BD04 Dofetilide
      D00647  Dofetilide (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Dofetilide
    D00647  Dofetilide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNH2
     D00647  Dofetilide (JAN/USAN/INN) <US>
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00647
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00647
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00647
BRITE hierarchy
Other DBs
CAS: 115256-11-6
PubChem: 7847713
ChEBI: 4681
ChEMBL: CHEMBL473
DrugBank: DB00204
LigandBox: D00647
NIKKAJI: J291.759I
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8y C    36.7713  -17.2369
            2   C8x C    35.5584  -17.9484
            3   C8x C    36.7713  -15.8199
            4   N1b N    37.9901  -17.9427
            5   C8x C    34.4038  -17.2369
            6   C8x C    35.5584  -15.1259
            7   S4a S    39.2206  -17.2369
            8   C8y C    34.3396  -15.8140
            9   C1a C    40.4278  -17.9427
            10  O3c O    37.9901  -16.5314
            11  O3c O    40.2937  -16.5255
            12  C1b C    33.1150  -15.1201
            13  C1b C    31.8962  -15.8082
            14  N1c N    30.6831  -15.1084
            15  C1b C    29.4702  -15.8023
            16  C1a C    30.6890  -13.7029
            17  C1b C    28.2514  -15.1025
            18  O2a O    27.0326  -15.7966
            19  C8y C    25.8197  -15.1025
            20  C8x C    25.8197  -13.7029
            21  C8x C    24.6066  -15.7966
            22  C8x C    24.6066  -12.9974
            23  C8x C    23.3937  -15.0968
            24  C8y C    23.3937  -13.6972
            25  N1b N    22.1806  -12.9857
            26  S4a S    20.9736  -13.6855
            27  C1a C    19.7665  -12.9740
            28  O3c O    19.7605  -14.3736
            29  O3c O    22.1806  -14.3853
BOND        30
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 2
            10    7  11 2
            11    8  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1
            16   15  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 2
            20   19  21 1
            21   20  22 1
            22   21  23 2
            23   22  24 2
            24   24  25 1
            25   25  26 1
            26   26  27 1
            27   26  28 2
            28   26  29 2
            29    6   8 2
            30   23  24 1

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