| Entry |
|
|---|
| Name |
Amiloride hydrochloride (USP);
Midamor (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C6H8ClN7O. 2H2O. HCl
|
|---|
| Exact mass |
301.0457
|
|---|
| Mol weight |
302.12
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01885 Potassium-sparing diuretic
|
|---|
| Remark |
| Product (DG00275): | D00649<US> |
| Product (mixture): | D10271<US> |
|
|---|
| Efficacy |
Diuretic, Epithelial sodium channel blocker |
|---|
| Comment |
potassium-sparing diuretic
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03D ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
C03DB Other potassium-sparing agents
C03DB01 Amiloride
D00649 Amiloride hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Potassium-sparing
Amiloride
D00649 Amiloride hydrochloride (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01885 Potassium-sparing diuretic
DG00275 Amiloride
D00649 Amiloride hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Epithelial sodium channel (SCNN)
SCNN1
D00649 Amiloride hydrochloride (USP) <US>
Drug groups [BR:br08330]
Cardiovascular agent
DG01885 Potassium-sparing diuretic
DG00275 Amiloride
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 18
1 C8y C 22.0858 -17.2962
2 C5a C 23.3026 -17.9925
3 C8y C 22.0858 -15.8920
4 N5x N 20.8805 -17.9925
5 N1b N 24.5137 -17.2904
6 O5a O 23.3026 -19.3907
7 N5x N 20.8805 -15.1959
8 N1a N 23.3026 -15.1959
9 C8y C 19.6636 -17.2962
10 C2c C 25.7247 -17.9925
11 C8y C 19.6636 -15.8920
12 X Cl 18.4466 -17.9925
13 N1a N 26.9358 -17.2904
14 N2a N 25.7247 -19.3907
15 N1a N 18.4466 -15.1959
16 O0 O 32.0313 -18.1505
17 X Cl 31.6217 -15.6801
18 O0 O 32.0313 -18.1505
BOND 15
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 7 11 1
11 9 12 1
12 10 13 1
13 10 14 2
14 11 15 1
15 9 11 2
BRACKET 1 30.0300 -19.1100 30.0300 -17.2200
1 32.6200 -17.2200 32.6200 -19.1100
1 2
ORIGINAL 1 16
REPEAT 1 18
|
|---|
