KEGG   DRUG: Flumazenil
Entry
D00697                      Drug                                   
Name
Flumazenil (JAN/USP/INN);
Romazicon (TN)
Product
  Generic
FLUMAZENIL (A-S Medication Solutions), FLUMAZENIL (Baxter Healthcare Corporation), FLUMAZENIL (Fresenius Kabi USA), FLUMAZENIL (HF Acquisition Co LLC), FLUMAZENIL (HF Acquisition Co. LLC), FLUMAZENIL (HF Acquisition Co. LLC), FLUMAZENIL (Henry Schein), FLUMAZENIL (Henry Schein), FLUMAZENIL (Henry Schein), FLUMAZENIL (Henry Schein), FLUMAZENIL (Hikma Pharmaceuticals USA), FLUMAZENIL (Hikma Pharmaceuticals USA), FLUMAZENIL (Medical Purchasing Solutions), FLUMAZENIL (Medical Purchasing Solutions), FLUMAZENIL (Medical Purchasing Solutions), FLUMAZENIL (Medical Purchasing Solutions)
Formula
C15H14FN3O3
Exact mass
303.1019
Mol weight
303.29
Structure
Simcomp
Remark
Same as: C07825
Therapeutic category: 2219
ATC code: V03AB25
Product: D00697<JP/US>
Efficacy
Antidote (benzodiazepines), Respiratory stimulant
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB25 Flumazenil
      D00697  Flumazenil (JAN/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   221  Respiratory stimulants
    2219  Others
     D00697  Flumazenil (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00697  Flumazenil (JAN/USP/INN) <JP/US>
Other DBs
CAS: 78755-81-4
PubChem: 7847762
ChEBI: 5103
PDB-CCD: FYP[PDBj]
LigandBox: D00697
NIKKAJI: J23.594F
LinkDB
KCF data

ATOM        22
            1   C5x C    10.4234  -11.5594
            2   C8y C     9.5813  -10.4498
            3   C8y C     9.9165   -9.0930
            4   N4y N    11.1775   -8.5149
            5   N1y N    11.8292  -11.5846
            6   C8y C    12.4311   -9.1372
            7   C1x C    12.7176  -10.5059
            8   C8x C     8.9094   -8.1246
            9   C8x C     7.5674   -8.5127
            10  C8y C     7.2322   -9.8695
            11  C8x C     8.2393  -10.8376
            12  X   F     5.8674  -10.2639
            13  O5x O     9.7889  -12.8091
            14  C1a C    12.4025  -12.8276
            15  C8y C    13.4103   -8.1372
            16  N5x N    12.7619   -6.8969
            17  C8x C    11.3820   -7.1303
            18  C7a C    14.8103   -8.1372
            19  O7a O    15.5101   -9.3492
            20  O6a O    15.5248   -6.8989
            21  C1b C    16.9396   -9.3485
            22  C1a C    17.6542  -10.5842
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 2
            15    5  14 1
            16    6  15 2
            17   15  16 1
            18   16  17 2
            19    4  17 1
            20   15  18 1
            21   18  19 1
            22   18  20 2
            23   19  21 1
            24   21  22 1

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