KEGG T01001: 2568

Homo sapiens (human): 2568

Entry

2568              CDS       T01001

Symbol

GABRP

Name

(RefSeq) gamma-aminobutyric acid type A receptor subunit pi

K05189

gamma-aminobutyric acid receptor subunit pi

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

D02594

Adinazolam (DG00911):

D02770 D02771

Adipiplon:

D08840

Alpidem:

D02833

Alprazolam:

D00225<JP/US>

Aminobutyric acid:

D00058<JP>

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

D01245<JP>

Brotizolam:

D01744<JP>

Butabarbital (DG01308):

D00699 D03180

Butobarbital:

D02618

Cenobamate:

D11150<US>

Chlordiazepoxide (DG00908):

D00267<JP> D00693<US>

Cinolazepam:

D07328

Cipepofol:

D12449

Clobazam:

D01253<JP/US>

Clonazepam:

D00280<JP/US>

Clotiazepam:

D01328<JP>

Cloxazolam:

D01268<JP>

Darigabat:

D12146

Delorazepam:

D07784

Dextofisopam:

D03737

Diazepam:

D00293<JP/US>

Estazolam:

D00311<JP/US>

Eszopiclone:

D02624<JP/US>

Ethyl loflazepate:

D01293<JP>

Etizolam:

D01514<JP>

Fludiazepam:

D01354

Flumazenil:

D00697<JP/US>

Flunitrazepam:

D01230<JP>

Flurazepam (DG00919):

D00329 D00695<US> D01408<JP>

Flutazolam:

D01286

Flutoprazepam:

D01279

Gaboxadol:

D04282

Ganaxolone:

D04300<US>

Glutethimide:

D00532

Halazepam:

D00338

Haloxazolam:

D01758<JP>

Hexobarbital:

D01071

Indiplon:

D02640

Iomazenil:

D02283<JP>

Ketazolam:

D04650

Levotofisopam:

D04721

Loprazolam (DG00921):

D07326 D08145

Lorazepam:

D00365<JP/US>

Lormetazepam:

D01657<JP>

Medazepam (DG00909):

D01292<JP> D04882

Meprobamate:

D00376<US>

Metharbital:

D01382

Methylphenobarbital:

D00700

Mexazolam:

D01316<JP>

Midazolam (DG00920):

D00550<JP/US> D00696<US> D05028

Nimetazepam:

D01593

Nitrazepam:

D00531<JP>

Nordazepam:

D08283

Ocinaplon:

D02617

Oxazepam:

D00464<US>

Oxazolam:

D01278<JP>

Pagoclone:

D02616

Panadiplon:

D05346

Pazinaclone:

D05378

Pentobarbital (DG00915):

D00499 D00500<US> D02253<JP>

Phenobarbital (DG00845):

D00506<JP> D00701<JP/US> D08356

Potassium clorazepate (DG01218):

D00694<JP/US> D03562

Prazepam:

D00470

Propofol (DG00797):

D00549<JP/US> D04257

Quazepam:

D00457<JP/US>

Remimazolam (DG03105):

D10194<JP/US> D11788

Rilmazafone (DG01307):

D01564<JP> D08481

Sarmazenil:

D08507

Secobarbital (DG00917):

D00430 D01310

Suritozole:

D05980

Talbutal:

D06887

Temazepam:

D00370<US>

Thiamylal (DG01377):

D00713<JP> D06106

Thiopental (DG00790):

D00714<JP>

Tofisopam:

D01254<JP>

Topiramate:

D00537<JP/US>

Triazolam:

D00387<JP/US>

Zolpidem (DG00922):

D00706<JP/US> D08690

Zopiclone:

D01372<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2568 (GABRP)
   04082 Neuroactive ligand signaling
    2568 (GABRP)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2568 (GABRP)
   04723 Retrograde endocannabinoid signaling
    2568 (GABRP)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2568 (GABRP)
   05033 Nicotine addiction
    2568 (GABRP)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2568 (GABRP)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2568 (GABRP)

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

5:170782720..170814047

AA seq 440 aa
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP
VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT
YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES
WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR
NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN
CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS
SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL
LFPLIFMLANVFYWAYYMYF

NT seq 1323 nt +upstreamnt +downstreamnt
atgaactacagcctccacttggccttcgtgtgtctgagtctcttcactgagaggatgtgc
atccaggggagtcagttcaacgtcgaggtcggcagaagtgacaagctttccctgcctggc
tttgagaacctcacagcaggatataacaaatttctcaggcccaattttggtggagaaccc
gtacagatagcgctgactctggacattgcaagtatctctagcatttcagagagtaacatg
gactacacagccaccatatacctccgacagcgctggatggaccagcggctggtgtttgaa
ggcaacaagagcttcactctggatgcccgcctcgtggagttcctctgggtgccagatact
tacattgtggagtccaagaagtccttcctccatgaagtcactgtgggaaacaggctcatc
cgcctcttctccaatggcacggtcctgtatgccctcagaatcacgacaactgttgcatgt
aacatggatctgtctaaataccccatggacacacagacatgcaagttgcagctggaaagc
tggggctatgatggaaatgatgtggagttcacctggctgagagggaacgactctgtgcgt
ggactggaacacctgcggcttgctcagtacaccatagagcggtatttcaccttagtcacc
agatcgcagcaggagacaggaaattacactagattggtcttacagtttgagcttcggagg
aatgttctgtatttcattttggaaacctacgttccttccactttcctggtggtgttgtcc
tgggtttcattttggatctctctcgattcagtccctgcaagaacctgcattggagtgacg
accgtgttatcaatgaccacactgatgatcgggtcccgcacttctcttcccaacaccaac
tgcttcatcaaggccatcgatgtgtacctggggatctgctttagctttgtgtttggggcc
ttgctagaatatgcagttgctcactacagttccttacagcagatggcagccaaagatagg
gggacaacaaaggaagtagaagaagtcagtattactaatatcatcaacagctccatctcc
agctttaaacggaagatcagctttgccagcattgaaatttccagcgacaacgttgactac
agtgacttgacaatgaaaaccagcgacaagttcaagtttgtcttccgagaaaagatgggc
aggattgttgattatttcacaattcaaaaccccagtaatgttgatcactattccaaacta
ctgtttcctttgatttttatgctagccaatgtattttactgggcatactacatgtatttt
tga

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