| Entry |
|
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| Name |
Naphazoline hydrochloride (JP18/USP);
Albalon (TN);
Vasocon (TN) |
|---|
| Formula |
C14H14N2. HCl
|
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| Exact mass |
246.0924
|
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| Mol weight |
246.73
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
|
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| Remark |
| Product (DG01032): | D01021<JP> |
|
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| Efficacy |
Vasoconstrictor, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Imidazoline derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AA Sympathomimetics, plain
R01AA08 Naphazoline
D00743 Naphazoline hydrochloride (JP18/USP)
R01AB Sympathomimetics, combinations excl. corticosteroids
R01AB02 Naphazoline
D00743 Naphazoline hydrochloride (JP18/USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA01 Naphazoline
D00743 Naphazoline hydrochloride (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for ophthalmologic use
62 General eye drops
D00743 Naphazoline hydrochloride (JP18/USP)
Agents for otolaryngologic use
70 Nasal sprays for inflammation
D00743 Naphazoline hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Naphazoline
D00743 Naphazoline hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01032 Naphazoline
D00743 Naphazoline hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00743 Naphazoline hydrochloride (JP18/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00743 Naphazoline hydrochloride
Rx-to-OTC switch list in the USA [br08315.html]
D00743
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01032 Naphazoline
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 17
1 X Cl 36.6100 -17.9200
2 C8y C 30.0300 -18.4100
3 C8y C 31.2200 -17.7100
4 C8y C 30.0300 -19.8100
5 C8x C 28.8400 -17.7100
6 C1b C 31.2200 -16.3100
7 C8x C 32.5500 -18.4100
8 C8x C 31.2200 -20.5100
9 C8x C 28.8400 -20.5100
10 C8x C 27.5800 -18.4100
11 C2y C 32.4800 -15.6100
12 C8x C 32.5500 -19.8100
13 C8x C 27.5800 -19.8100
14 N1x N 33.8100 -16.1000
15 N2x N 32.4800 -14.2800
16 C1x C 34.6500 -14.9100
17 C1x C 33.8100 -13.7900
BOND 18
1 2 3 1
2 2 4 2
3 2 5 1
4 3 6 1
5 3 7 2
6 4 8 1
7 4 9 1
8 5 10 2
9 6 11 1
10 7 12 1
11 9 13 2
12 11 14 1
13 11 15 2
14 14 16 1
15 15 17 1
16 8 12 2
17 10 13 1
18 16 17 1
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