KEGG   DRUG: Interferon alfa-2a
Entry
D00745                      Drug                                   

Name
Interferon alfa-2a (USAN/INN);
Interferon alfa-2a (genetical recombination) (JAN);
Roferon A (TN)
Formula
C860H1353N227O255S9
Exact mass
19228.7369
Mol weight
19240.8977
Sequence
CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
  Type
Peptide
Class
Antineoplastic
 DG01752  Interferone
Remark
ATC code: L03AB04
Chemical structure group: DG01750
Product (DG01750): D02745<US> D03305<JP> D04553<US>
Efficacy
Antineoplastic, Biological response modifier
Target
IFNAR1 [HSA:3454] [KO:K05130]
IFNAR2 [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB04 Interferon alfa-2a
      D00745  Interferon alfa-2a (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interferon receptors
    IFNAR1
     D00745  Interferon alfa-2a (USAN/INN)
    IFNAR2
     D00745  Interferon alfa-2a (USAN/INN)
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Entry, fusion or uncoating inhibitor
   Interferon
    DG01750  Interferon alpha
Other DBs
CAS: 76543-88-9
PubChem: 7847810
ChEBI: 5937
DrugBank: DB00034
LinkDB

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