KEGG   Homo sapiens (human): 3454
Entry
3454              CDS       T01001                                 
Symbol
IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, IMD106
Name
(RefSeq) interferon alpha and beta receptor subunit 1
  KO
K05130  interferon receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06219  JAK-STAT signaling (cancer)
nt06222  IFN signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06517  TLR signaling
nt06518  JAK-STAT signaling
nt06527  Necroptosis
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00150  Type I IFN signaling pathway
N00471  EBV LMP2A/2B to IFN signaling pathway
N01558  Type I interferon to Jak-STAT signaling pathway
N01662  IFN-RIPK1/3 signaling pathway
Disease
H02525  Disorders of innate immunity
Drug target
Albinterferon alfa-2b: D08844
Anifrolumab: D11082<JP/US>
Interferon alfa natural: D03305<JP>
Interferon alfa-2a: D00745
Interferon alfa-2b: D02745
Interferon alfa-n1: D04552
Interferon alfacon-1: D02744
Interferon alpha  
(abbr) INFalpha (DG01750): D04553
Interferon beta natural: D03304
Interferon beta-1a: D04554<JP/US>
Interferon beta-1b: D00746<JP/US>
Peginterferon alfa-2a: D02747<JP/US>
Peginterferon alfa-2b: D02748
Peginterferon beta-1a: D10483<US>
Ropeginterferon alfa-2b: D11027<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3454 (IFNAR1)
   04151 PI3K-Akt signaling pathway
    3454 (IFNAR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3454 (IFNAR1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3454 (IFNAR1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3454 (IFNAR1)
   04621 NOD-like receptor signaling pathway
    3454 (IFNAR1)
   04650 Natural killer cell mediated cytotoxicity
    3454 (IFNAR1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3454 (IFNAR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3454 (IFNAR1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    3454 (IFNAR1)
   05160 Hepatitis C
    3454 (IFNAR1)
   05171 Coronavirus disease - COVID-19
    3454 (IFNAR1)
   05164 Influenza A
    3454 (IFNAR1)
   05162 Measles
    3454 (IFNAR1)
   05168 Herpes simplex virus 1 infection
    3454 (IFNAR1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3454 (IFNAR1)
   05169 Epstein-Barr virus infection
    3454 (IFNAR1)
   05165 Human papillomavirus infection
    3454 (IFNAR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3454 (IFNAR1)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IFN receptor family
   3454 (IFNAR1)
SSDB
Motif
Pfam: Interfer-bind Tissue_fac fn3 Pombe_5TM
Other DBs
NCBI-GeneID: 3454
NCBI-ProteinID: NP_000620
OMIM: 107450
HGNC: 5432
Ensembl: ENSG00000142166
UniProt: P17181
Structure
LinkDB
Position
21:33324395..33359864
AA seq 557 aa
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVT
FSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSF
TPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERI
ENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQ
NQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQK
GIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTP
VIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSV
FSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDE
YFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSN
EDESESKTSEELQQDFV
NT seq 1674 nt   +upstreamnt  +downstreamnt
atgatggtcgtcctcctgggcgcgacgaccctagtgctcgtcgccgtggcgccatgggtg
ttgtccgcagccgcaggtggaaaaaatctaaaatctcctcaaaaagtagaggtcgacatc
atagatgacaactttatcctgaggtggaacaggagcgatgagtctgtcgggaatgtgact
ttttcattcgattatcaaaaaactgggatggataattggataaaattgtctgggtgtcag
aatattactagtaccaaatgcaacttttcttcactcaagctgaatgtttatgaagaaatt
aaattgcgtataagagcagaaaaagaaaacacttcttcatggtatgaggttgactcattt
acaccatttcgcaaagctcagattggtcctccagaagtacatttagaagctgaagataag
gcaatagtgatacacatctctcctggaacaaaagatagtgttatgtgggctttggatggt
ttaagctttacatatagcttagttatctggaaaaactcttcaggtgtagaagaaaggatt
gaaaatatttattccagacataaaatttataaactctcaccagagactacttattgtcta
aaagttaaagcagcactacttacgtcatggaaaattggtgtctatagtccagtacattgt
ataaagaccacagttgaaaatgaactacctccaccagaaaatatagaagtcagtgtccaa
aatcagaactatgttcttaaatgggattatacatatgcaaacatgacctttcaagttcag
tggctccacgcctttttaaaaaggaatcctggaaaccatttgtataaatggaaacaaata
cctgactgtgaaaatgtcaaaactacccagtgtgtctttcctcaaaacgttttccaaaaa
ggaatttaccttctccgcgtacaagcatctgatggaaataacacatctttttggtctgaa
gagataaagtttgatactgaaatacaagctttcctacttcctccagtctttaacattaga
tcccttagtgattcattccatatctatatcggtgctccaaaacagtctggaaacacgcct
gtgatccaggattatccactgatttatgaaattattttttgggaaaacacttcaaatgct
gagagaaaaattatcgagaaaaaaactgatgttacagttcctaatttgaaaccactgact
gtatattgtgtgaaagccagagcacacaccatggatgaaaagctgaataaaagcagtgtt
tttagtgacgctgtatgtgagaaaacaaaaccaggaaatacctctaaaatttggcttata
gttggaatttgtattgcattatttgctctcccgtttgtcatttatgctgcgaaagtcttc
ttgagatgcatcaattatgtcttctttccatcacttaaaccttcttccagtatagatgag
tatttctctgaacagccattgaagaatcttctgctttcaacttctgaggaacaaatcgaa
aaatgtttcataattgaaaatataagcacaattgctacagtagaagaaactaatcaaact
gatgaagatcataaaaaatacagttcccaaactagccaagattcaggaaattattctaat
gaagatgaaagcgaaagtaaaacaagtgaagaactacagcaggactttgtatga

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