KEGG   DRUG: Mycophenolate mofetil
Entry
D00752                      Drug                                   
Name
Mycophenolate mofetil (JAN/USP);
Cellcept (TN)
Product
  Generic
MYCOPHENOLATE MOFETIL (A-S Medication Solutions), MYCOPHENOLATE MOFETIL (A-S Medication Solutions), MYCOPHENOLATE MOFETIL (Accord Healthcare), MYCOPHENOLATE MOFETIL (Akorn), MYCOPHENOLATE MOFETIL (Akorn), MYCOPHENOLATE MOFETIL (American Health Packaging), MYCOPHENOLATE MOFETIL (American Health Packaging), MYCOPHENOLATE MOFETIL (Amneal Pharmaceuticals LLC), MYCOPHENOLATE MOFETIL (Amneal Pharmaceuticals NY LLC), MYCOPHENOLATE MOFETIL (Amneal Pharmaceuticals NY LLC), MYCOPHENOLATE MOFETIL (Aphena Pharma Solutions - Tennessee), MYCOPHENOLATE MOFETIL (Ascend Laboratories), MYCOPHENOLATE MOFETIL (Ascend Laboratories), MYCOPHENOLATE MOFETIL (Avet Pharmaceuticals), MYCOPHENOLATE MOFETIL (Avet Pharmaceuticals), MYCOPHENOLATE MOFETIL (Bryant Ranch Prepack), MYCOPHENOLATE MOFETIL (CONCORD BIOTECH LIMITED), MYCOPHENOLATE MOFETIL (CONCORD BIOTECH LIMITED), MYCOPHENOLATE MOFETIL (Cardinal Health), MYCOPHENOLATE MOFETIL (Cardinal Health 107), MYCOPHENOLATE MOFETIL (Golden State Medical Supply), MYCOPHENOLATE MOFETIL (Hikma Pharmaceuticals USA), MYCOPHENOLATE MOFETIL (Lannett Company), MYCOPHENOLATE MOFETIL (Lupin Pharmaceuticals), MYCOPHENOLATE MOFETIL (Lupin Pharmaceuticals), MYCOPHENOLATE MOFETIL (Major Pharmaceuticals), MYCOPHENOLATE MOFETIL (Major Pharmaceuticals), MYCOPHENOLATE MOFETIL (Meitheal Pharmaceuticals), MYCOPHENOLATE MOFETIL (Mylan Institutional), MYCOPHENOLATE MOFETIL (Mylan Institutional LLC), MYCOPHENOLATE MOFETIL (Mylan Pharmaceuticals), MYCOPHENOLATE MOFETIL (NorthStar RxLLC), MYCOPHENOLATE MOFETIL (Par Pharmaceutical), MYCOPHENOLATE MOFETIL (REMEDYREPACK), MYCOPHENOLATE MOFETIL (REMEDYREPACK), MYCOPHENOLATE MOFETIL (REMEDYREPACK), MYCOPHENOLATE MOFETIL (Sandoz), MYCOPHENOLATE MOFETIL (Strides Pharma Science Limited), MYCOPHENOLATE MOFETIL (Teva Pharmaceuticals USA), MYCOPHENOLATE MOFETIL (Teva Pharmaceuticals USA), MYCOPHENOLATE MOFETIL (Teva Pharmaceuticals), MYCOPHENOLATE MOFETIL (VistaPharm), MYCOPHENOLATE MOFETIL (Zydus Lifesciences Limited), MYCOPHENOLATE MOFETIL (Zydus Pharmaceuticals USA)
Formula
C23H31NO7
Exact mass
433.2101
Mol weight
433.4947
Structure
Simcomp
Remark
Same as: C07908
Therapeutic category: 3999
ATC code: L04AA06
Chemical structure group: DG00739
Product (DG00739): D00752<JP/US> D05094<US> D05095<US>
Efficacy
Immunosuppressant, Inosine monophosphate dehydrogenase inhibitor
  Disease
Prophylaxis of organ rejection [DS:H00083]
Comment
Active form of prodrug: Mycophenolic acid [DR:D05096]
Target
IMPDH [HSA:3614 3615] [KO:K00088]
  Pathway
hsa00230  Purine metabolism
Interaction
Structure map
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA06 Mycophenolic acid
      D00752  Mycophenolate mofetil (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunosuppressants
   Antimetabolites, Antiproliferative
    Mycophenolic Acid
     D00752  Mycophenolate mofetil (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00752  Mycophenolate mofetil (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    IMPDH
     D00752  Mycophenolate mofetil (JAN/USP) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00752
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00752
Prodrugs [br08324.html]
 D00752
Prodrugs [br08324.html]
 DG00739
Other DBs
CAS: 128794-94-5
PubChem: 7847817
ChEBI: 8764
LigandBox: D00752
NIKKAJI: J378.713C
LinkDB
KCF data

ATOM        31
            1   C8y C    32.4696  -17.7102
            2   C8y C    32.4638  -16.2982
            3   C8y C    31.2561  -18.4045
            4   C1x C    33.8058  -18.1420
            5   C8y C    31.2561  -15.5981
            6   C7x C    33.7999  -15.8664
            7   C8y C    30.0424  -17.7102
            8   C1a C    31.2561  -19.8107
            9   O7x O    34.6284  -17.0042
            10  C8y C    30.0424  -16.2982
            11  O1a O    31.2561  -14.1978
            12  O6a O    34.2376  -14.5304
            13  O2a O    28.8289  -18.4045
            14  C1b C    28.8289  -15.5981
            15  C1a C    28.8289  -19.8107
            16  C2b C    27.6154  -16.2925
            17  C2c C    26.4017  -15.5923
            18  C1b C    25.1939  -16.2866
            19  C1a C    26.4076  -14.1920
            20  C1b C    23.9804  -15.5864
            21  C7a C    22.7668  -16.2749
            22  O7a O    21.5532  -15.5807
            23  O6a O    22.7610  -17.6810
            24  C1b C    20.3455  -16.2691
            25  C1b C    19.1377  -15.5747
            26  N1y N    17.9242  -16.2632
            27  C1x C    16.7164  -15.5631
            28  C1x C    17.9183  -17.6578
            29  C1x C    15.5087  -16.2575
            30  C1x C    16.7048  -18.3579
            31  O2x O    15.5728  -17.6519
BOND        33
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13   10  14 1
            14   13  15 1
            15   14  16 1
            16   16  17 2
            17   17  18 1
            18   17  19 1
            19   18  20 1
            20   20  21 1
            21   21  22 1
            22   21  23 2
            23   22  24 1
            24   24  25 1
            25   25  26 1
            26   26  27 1
            27   26  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31    6   9 1
            32    7  10 1
            33   30  31 1

» Japanese version   » Back

KEGG   DRUG: Mycophenolate mofetil hydrochloride
Entry
D05094                      Drug                                   
Name
Mycophenolate mofetil hydrochloride (USAN);
Cellcept (TN)
Product
Formula
C23H31NO7. HCl
Exact mass
469.1867
Mol weight
469.9557
Structure
Simcomp
Remark
ATC code: L04AA06
Chemical structure group: DG00739
Product (DG00739): D00752<JP/US> D05094<US> D05095<US>
Efficacy
Immunosuppressant, Inosine monophosphate dehydrogenase inhibitor
Comment
Active form of prodrug: Mycophenolic acid [DR:D05096]
Target
IMPDH [HSA:3614 3615] [KO:K00088]
  Pathway
hsa00230  Purine metabolism
Interaction
Structure map
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA06 Mycophenolic acid
      D05094  Mycophenolate mofetil hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    IMPDH
     D05094  Mycophenolate mofetil hydrochloride (USAN) <US>
Prodrugs [br08324.html]
 DG00739
Other DBs
CAS: 116680-01-4
PubChem: 47206819
LigandBox: D05094
LinkDB
KCF data

ATOM        32
            1   C8y C    32.5108  -17.7327
            2   C8y C    32.5050  -16.3189
            3   C8y C    31.2957  -18.4278
            4   C1x C    33.8487  -18.1650
            5   C8y C    31.2957  -15.6179
            6   C7x C    33.8427  -15.8865
            7   C8y C    30.0805  -17.7327
            8   C1a C    31.2957  -19.8358
            9   O7x O    34.6723  -17.0258
            10  C8y C    30.0805  -16.3189
            11  O1a O    31.2957  -14.2158
            12  O6a O    34.2810  -14.5488
            13  O2a O    28.8654  -18.4278
            14  C1b C    28.8654  -15.6179
            15  C1a C    28.8654  -19.8358
            16  C2b C    27.6504  -16.3132
            17  C2c C    26.4352  -15.6121
            18  C1b C    25.2258  -16.3072
            19  C1a C    26.4411  -14.2100
            20  C1b C    24.0108  -15.6062
            21  C7a C    22.7957  -16.2955
            22  O7a O    21.5805  -15.6005
            23  O6a O    22.7899  -17.7034
            24  C1b C    20.3713  -16.2897
            25  C1b C    19.1620  -15.5944
            26  N1y N    17.9469  -16.2838
            27  C1x C    16.7376  -15.5828
            28  C1x C    17.9410  -17.6802
            29  C1x C    15.5284  -16.2781
            30  C1x C    16.7260  -18.3812
            31  O2x O    15.5225  -17.6743
            32  X   Cl   37.3800  -19.1800
BOND        33
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13   10  14 1
            14   13  15 1
            15   14  16 1
            16   16  17 2
            17   17  18 1
            18   17  19 1
            19   18  20 1
            20   20  21 1
            21   21  22 1
            22   21  23 2
            23   22  24 1
            24   24  25 1
            25   25  26 1
            26   26  27 1
            27   26  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31    6   9 1
            32    7  10 1
            33   30  31 1

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