KEGG T01001: 3614

Homo sapiens (human): 3614

Entry

3614              CDS       T01001

Symbol

IMPDH1, IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608

Name

(RefSeq) inosine monophosphate dehydrogenase 1

K00088

IMP dehydrogenase [EC:1.1.1.205]

Organism

hsa Homo sapiens (human)

Pathway

hsa00230

Purine metabolism

hsa00983

Drug metabolism - other enzymes

hsa01100

Metabolic pathways

hsa01232

Nucleotide metabolism

Module

hsa_M00050

Guanine ribonucleotide biosynthesis, IMP => GDP,GTP

Disease

H00527

Retinitis pigmentosa

H00837

Leber congenital amaurosis

Drug target

Merimepodib:

D04936

Mizoribine:

D01392<JP>

Mycophenolic acid (DG00739):

D00752<JP/US> D05094<US> D05095<US> D05096

Tiazofurine:

D06130

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    3614 (IMPDH1)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    3614 (IMPDH1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3614 (IMPDH1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.205  IMP dehydrogenase
     3614 (IMPDH1)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3614 (IMPDH1)
  Exosomal proteins of breast cancer cells
   3614 (IMPDH1)

SSDB

Motif

Pfam:

IMPDH CBS NMO FMN_dh His_biosynth NanE Glu_synthase ThiG DHO_dh B12-binding G3P_antiterm YceG_bac

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

7:complement(128392277..128409982)

AA seq 514 aa
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY

NT seq 1545 nt +upstreamnt +downstreamnt
atggcggactacctgatcagcggcggcaccggctacgtgcccgaggatgggctcaccgcg
cagcagctcttcgccagcgccgacggcctcacctacaacgacttcctgattctcccagga
ttcatagacttcatagctgatgaggtggacctgacctcagccctgacccggaagatcacg
ctgaagacgccactgatctcctcccccatggacactgtgacagaggctgacatggccatt
gccatggctctgatgggaggtattggtttcattcaccacaactgcaccccagagttccag
gccaacgaggtgcggaaggtcaagaagtttgaacagggcttcatcacggaccctgtggtg
ctgagcccctcgcacactgtgggcgatgtgctggaggccaagatgcggcatggcttctct
ggcatccccatcactgagacgggcaccatgggcagcaagctggtgggcatcgtcacctcc
cgagacatcgactttcttgctgagaaggaccacaccaccctcctcagtgaggtgatgacg
ccaaggattgaactggtggtggctccagcaggtgtgacgttgaaagaggcaaatgagatc
ctgcagcgtagcaagaaagggaagctgcctatcgtcaatgattgcgatgagctggtggcc
atcatcgcccgcaccgacctgaagaagaaccgagactaccctctggcctccaaggattcc
cagaagcagctgctctgtggggcagctgtgggcacccgtgaggatgacaaataccgtctg
gacctgctcacccaggcgggcgtcgacgtcatagtcttggactcgtcccaagggaattcg
gtgtatcagatcgccatggtgcattacatcaaacagaagtacccccacctccaggtgatt
ggggggaacgtggtgacagcagcccaggccaagaacctgattgatgctggtgtggacggg
ctgcgcgtgggcatgggctgcggctccatctgcatcacccaggaagtgatggcctgtggt
cggccccagggcactgctgtgtacaaggtggctgagtatgcccggcgctttggtgtgccc
atcatagccgatggcggcatccagaccgtgggacacgtggtcaaggccctggcccttgga
gcctccacagtgatgatgggctccctgctggccgccactacggaggcccctggcgagtac
ttcttctcagacggggtgcggctcaagaagtaccggggcatgggctcactggatgccatg
gagaagagcagcagcagccagaaacgatacttcagcgagggggataaagtgaagatcgcg
cagggtgtctcgggctccatccaggacaaaggatccattcagaagttcgtgccctacctc
atagcaggcatccaacacggctgccaggatatcggggcccgcagcctgtctgtccttcgg
tccatgatgtactcaggagagctcaagtttgagaagcggaccatgtcggcccagattgag
ggtggtgtccatggcctgcactcttacgaaaagcggctgtactga

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