| Entry |
|
|---|
| Name |
Tetrahydrozoline nitrate (JAN);
Narbel (TN) |
|---|
| Formula |
C13H16N2. HNO3
|
|---|
| Exact mass |
263.127
|
|---|
| Mol weight |
263.2924
|
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| Structure |
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
|
|---|
| Remark |
|
|---|
| Efficacy |
Vasoconstrictor, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Imidazoline derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AA Sympathomimetics, plain
R01AA06 Tetryzoline
D00756 Tetrahydrozoline nitrate (JAN)
R01AB Sympathomimetics, combinations excl. corticosteroids
R01AB03 Tetryzoline
D00756 Tetrahydrozoline nitrate (JAN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA02 Tetryzoline
D00756 Tetrahydrozoline nitrate (JAN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for otolaryngologic use
70 Nasal sprays for inflammation
D00756 Tetrahydrozoline nitrate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Tetryzoline
D00756 Tetrahydrozoline nitrate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01030 Tetryzoline
D00756 Tetrahydrozoline nitrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00756 Tetrahydrozoline nitrate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01030 Tetryzoline
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 19
1 C8x C 12.8100 -18.6900
2 C8x C 12.8100 -17.2900
3 C8x C 14.0000 -16.5900
4 C8y C 15.2600 -17.2900
5 C8y C 15.2600 -18.6900
6 C8x C 14.0000 -19.3900
7 C1y C 16.4500 -16.5900
8 C1x C 17.6400 -17.2900
9 C1x C 17.6400 -18.6900
10 C1x C 16.4500 -19.3900
11 C2y C 16.4500 -15.1900
12 N2x N 15.3300 -14.3500
13 C1x C 15.7500 -13.0200
14 C1x C 17.1500 -13.0200
15 N1x N 17.5700 -14.3500
16 O3a O 21.4200 -16.8000
17 N2b N 21.4200 -18.2000 #+
18 O1b O 20.1600 -18.9000
19 O3a O 22.6100 -18.9000 #-
BOND 20
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 7 11 1
13 11 12 2
14 12 13 1
15 13 14 1
16 14 15 1
17 11 15 1
18 16 17 2
19 17 18 1
20 17 19 1
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