KEGG   DRUG: MetyrosineHelp
Entry
D00762                      Drug                                   

Name
Metyrosine (USP);
Metirosine (JAN/INN);
Demser (TN)
Product
Formula
C10H13NO3
Exact mass
195.0895
Mol weight
195.2151
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01617  Catecholamine synthesis inhibitors
Remark
Same as: C07921
ATC code: C02KB01
Product: D00762<US>
Efficacy
Antihypertensive, Tyrosine monooxygenase inhibitor
  Disease
Pheochromocytoma
Comment
Tyrosine derivative
Target
TH [HSA:7054] [KO:K00501]
  Pathway
hsa00350  Tyrosine metabolism
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02K OTHER ANTIHYPERTENSIVES
    C02KB Tyrosine hydroxylase inhibitors
     C02KB01 Metirosine
      D00762  Metyrosine (USP) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Other monooxygenases
    TH
     D00762  Metyrosine (USP) <US>
BRITE hierarchy
Other DBs
CAS: 672-87-7
PubChem: 7847827
ChEBI: 6912
ChEMBL: CHEMBL1200862
DrugBank: DB00765
LigandBox: D00762
NIKKAJI: J9.465J
LinkDB All DBs
KCF data Show

ATOM        14
            1   C1d C    20.4400  -16.2400
            2   C6a C    21.6300  -15.5400
            3   C1b C    19.2500  -15.5400
            4   C1a C    19.6700  -17.5700
            5   N1a N    21.3500  -17.2900
            6   O6a O    22.8200  -16.2400
            7   O6a O    21.6300  -14.1400
            8   C8y C    17.9900  -16.2400
            9   C8x C    17.9900  -17.5700
            10  C8x C    16.8000  -15.5400
            11  C8x C    16.8000  -18.2700
            12  C8x C    15.6100  -16.2400
            13  C8y C    15.6100  -17.5700
            14  O1a O    14.4200  -18.2700
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     8   9 2
            9     8  10 1
            10    9  11 1
            11   10  12 2
            12   11  13 2
            13   13  14 1
            14   12  13 1

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