KEGG   ORTHOLOGY: K00501
Entry
K00501                      KO                                     

Symbol
TH
Name
tyrosine 3-monooxygenase [EC:1.14.16.2]
Pathway
map00350  Tyrosine metabolism
map00790  Folate biosynthesis
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04728  Dopaminergic synapse
map04917  Prolactin signaling pathway
map05012  Parkinson disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00501  TH; tyrosine 3-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K00501  TH; tyrosine 3-monooxygenase
  09156 Nervous system
   04728 Dopaminergic synapse
    K00501  TH; tyrosine 3-monooxygenase
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K00501  TH; tyrosine 3-monooxygenase
  09165 Substance dependence
   05030 Cocaine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05031 Amphetamine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05034 Alcoholism
    K00501  TH; tyrosine 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     K00501  TH; tyrosine 3-monooxygenase
Other DBs
RN: R01815 R07212
GO: 0004511
Genes
HSA: 7054(TH)
PTR: 450955(TH)
PPS: 100967895(TH)
GGO: 101135345(TH)
PON: 100454349(TH)
NLE: 100591963(TH)
MCC: 721137(TH)
MCF: 102134074(TH)
CSAB: 103238895(TH)
CATY: 105577265(TH)
PANU: 100997633(TH)
RRO: 104677105(TH)
RBB: 108539190(TH)
TFN: 117081144(TH)
PTEH: 111520620(TH)
CJC: 100393454(TH)
SBQ: 101037795(TH)
MMUR: 105859820(TH)
MMU: 21823(Th)
MCAL: 110298803(Th)
MPAH: 110327669(Th)
RNO: 25085(Th)
MCOC: 116103251(Th)
MUN: 110547270(Th)
PLEU: 114694083(Th)
NGI: 103738985(Th)
HGL: 101721615(Th)
CPOC: 100734150(Th)
CCAN: 109689795(Th)
TUP: 102482570(TH)
CFA: 403444(TH)
VVP: 112924141(TH)
VLG: 121472267(TH)
AML: 100483681(TH)
UMR: 103671121(TH)
UAH: 113243914(TH)
ORO: 101384343(TH)
ELK: 111149999
MPUF: 101682802(TH)
EJU: 114220499(TH)
MLX: 118015655(TH)
FCA: 101090720(TH)
PYU: 121023849(TH)
PBG: 122484125(TH)
PTG: 102954972(TH)
PPAD: 109259420(TH)
AJU: 106971078(TH)
HHV: 120226898(TH)
BTA: 280707(TH)
BOM: 102274970(TH)
BIU: 109554672(TH)
BBUB: 102395073(TH)
CHX: 102179849(TH)
OAS: 101120619(TH)
ODA: 120874169(TH)
CCAD: 122430977(TH)
SSC: 110259705(TH)
CFR: 102508286(TH)
CBAI: 105070385(TH)
CDK: 105106406(TH)
BACU: 103020745(TH)
LVE: 103086024(TH)
OOR: 101278256(TH)
DLE: 111184074(TH)
PCAD: 102996827(TH)
PSIU: 116757983(TH)
ECB: 100146648(TH)
EAI: 106824091(TH)
MYD: 102756871(TH)
MMYO: 118659614(TH)
MNA: 107539915(TH)
PKL: 118713980(TH)
HAI: 109395916(TH)
DRO: 112317145(TH)
SHON: 118988339(TH)
AJM: 119057534(TH)
PDIC: 114500037(TH)
MMF: 118628135(TH)
RFQ: 117030018(TH)
PGIG: 120584600(TH)
RAY: 107513264(TH)
MJV: 108402611(TH)
TOD: 119248786(TH)
TMU: 101347132
MDO: 100021373
GAS: 123248657
GGA: 395592(TH) 771761(THL)
PCOC: 116226760 116242979(TH)
MGP: 723977(TH)
NMEL: 110398023 110401820(TH)
APLA: 101794316 101794610(TH)
ACYG: 106035805 106042638(TH)
SCAN: 103819711 103826755(TH)
PMOA: 120501694 120511421(TH)
PRUF: 121360967(TH) 121363538
PMAJ: 107204189 107205413(TH)
CCAE: 111930777(TH) 111931331
ACUN: 113481167(TH) 113488615
PADL: 103920696(TH) 103924526
AROW: 112972432(TH)
DNE: 112978953(TH)
CPOO: 109315934 109321480(TH)
CPIC: 101937054(TH) 101942670
CABI: 116819344(TH) 116819879
SUND: 121922073(TH) 121930910
PMUR: 107289468 107294041(TH)
PGUT: 117655512 117665229(TH)
PMUA: 114599115(TH) 114605512
XLA: 100037248(th.S) 108710245(th2.L) 108713461(th.L)
XTR: 100488900(th) 100495856(th2)
DRE: 30384(th) 414844(th2)
PHYP: 113529896(th) 113532096
AMEX: 103023599(th) 103026162
TRU: 101078018(th) 446095
CGOB: 115009621(th) 115028288
ELY: 117249390(th2) 117261762(th)
PLEP: 121949711(th) 121961151(th2)
SLUC: 116038785(th) 116060201(th2)
ECRA: 117938735(th2) 117948912(th)
PFLV: 114550010 114560170(th)
GAT: 120809587(th) 120818263(th2)
PPUG: 119196712(th) 119210571(th2)
MSAM: 119894432(th) 119917964(th2)
CUD: 121505421(th2) 121515137(th)
OAU: 116325448(th2) 116328933(th)
OLA: 101168664(th2) 101171548(th)
OML: 112152448(th) 112159073(th2)
PRET: 103459397 103466160(th)
GAF: 122826240(th2) 122834999(th)
CTUL: 119781003(th2) 119796768(th)
KMR: 108233218(th2) 108237537(th)
ALIM: 106515667(th) 106530261
AOCE: 111582533(th) 111586653
SSEN: 122766054(th2) 122775716(th)
HHIP: 117757137(th2) 117763623(th)
SLAL: 111661851(th) 111664688
XGL: 120793270(th) 120799032(th2)
BPEC: 110161487 110165894(th)
MALB: 109967816 109967893(th)
OMY: 110490795(th) 110500050(th2)
SALP: 111961998(th) 111982828
AANG: 118215238 118227840(th) 118232061(th2)
LOC: 102688831(th)
CMK: 103179919(th2) 103186002(th)
BFO: 118407893
BBEL: 109477347
CIN: 493867(th)
SCLV: 120331903
SPU: 581094
SKO: 100329060(TH)
DME: Dmel_CG10118(ple)
DER: 6544948
DSE: 6611046
DSI: Dsimw501_GD13115(Dsim_GD13115)
DAN: 6493759
DSR: 110178770
DPE: 6601668
DMN: 108153568
DWI: 6645135
DGR: 6558407
DAZ: 108614271
DNV: 108652194
DHE: 111600489
DVI: 6623552
CCAT: 101450123
BOD: 106624120
MDE: 101896218
SCAC: 106094605
LCQ: 111683620
ACOZ: 120949126
AARA: 120908669
AAG: 23687518
AALB: 109413955
CPII: 120412867
AME: 408930(TyHyd)
ACER: 107999422
BIM: 100750025
BBIF: 117213312
BVK: 117235037
BVAN: 117158685
BTER: 100646624
BPYO: 122568852
CCAL: 108629537
OBB: 114876902
MGEN: 117228419
NMEA: 116424395
CGIG: 122401921
SOC: 105194448
MPHA: 105838942
AEC: 105145056
ACEP: 105619344
PBAR: 105423652
VEM: 105567121
HST: 105182098
DQU: 106750925
CFO: 105248912
FEX: 115232865
LHU: 105678075
PGC: 109861504
OBO: 105279021
PCF: 106786223
PFUC: 122514164
VPS: 122634890
NVI: 100116056
CSOL: 105360534
TPRE: 106652462
MDL: 103574339
CGLO: 123266818
FAS: 105264303
DAM: 107047468
AGIF: 122856602
CCIN: 107269432
TCA: 654918(Th)
DPA: 109541904
ATD: 109599398
AGB: 108910114
LDC: 111515317
NVL: 108569991
APLN: 108732435
PPYR: 116173388
OTU: 111418800
BMOR: 100270767(Th)
BMAN: 114244521
MSEX: 115441153
BANY: 112049720
PMAC: 106717258
PPOT: 106104489
PXU: 106126313
PRAP: 110997603
ZCE: 119835458
HAW: 110377808
TNL: 113493935
PXY: 105380496(Th)
API: 100167369
DNX: 107161975
AGS: 114123079
RMD: 113554456
BTAB: 109044321
CLEC: 106664402
HHAL: 106690021
NLU: 111049383
FOC: 113202097
ZNE: 110829545
CSEC: 111866340
FCD: 110862051
DMK: 116920573
PVM: 113810884
PJA: 122264525
HAME: 121861638
HAZT: 108677274
EAF: 111708445
DSV: 119464389
RSAN: 119401301
VDE: 111252586
VJA: 111263052
TUT: 107359687
DPTE: 113794892
CSCU: 111638578
CEL: CELE_B0432.5(cat-2)
CBR: CBG_07026(Cbr-cat-2)
BMY: BM_BM4930(Bma-cat-2)
TSP: Tsp_12013
PCAN: 112566735
BGT: 106070594
GAE: 121372643
MYI: 110459086
PMAX: 117327869
OBI: 106871451
OSN: 115215438
SGM: GCM10017557_00900(phhA)
FTJ: FTUN_0679
 » show all
Reference
  Authors
Daubner SC, Le T, Wang S
  Title
Tyrosine hydroxylase and regulation of dopamine synthesis.
  Journal
Arch Biochem Biophys 508:1-12 (2011)
DOI:10.1016/j.abb.2010.12.017
Reference
PMID:2887169
  Authors
Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T
  Title
Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.
  Journal
Biochem Biophys Res Commun 146:971-5 (1987)
DOI:10.1016/0006-291x(87)90742-x
  Sequence
[hsa:7054]
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