KEGG   DRUG: NatamycinHelp
Entry
D00884                      Drug                                   

Name
Natamycin (USP/INN);
Pimaricin (JP17);
PMR;
Natacyn (TN)
Product
Formula
C33H47NO13
Exact mass
665.3047
Mol weight
665.7252
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Sequence
0 Mak  1 Mad  2 Mad  3 Mad  4 Mad  5 Mak  6 Mak  7 Mtk  8 Man
9 Mak  10 Mad  11 Mad  12 Man
  Type
PK
Source
Streptomyces natalensis [TAX:68242]
Remark
Same as: C08073
Therapeutic category: 1317
ATC code: A01AB10 A07AA03 D01AA02 G01AA02 S01AA10
Product: D00884<JP/US>
Efficacy
Antibacterial, Antifungal
Comment
Polyene
Target
Ergosterol
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB10 Natamycin
      D00884  Natamycin (USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA03 Natamycin
      D00884  Natamycin (USP/INN) <JP/US>
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AA Antibiotics
     D01AA02 Natamycin
      D00884  Natamycin (USP/INN) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA02 Natamycin
      D00884  Natamycin (USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA10 Natamycin
      D00884  Natamycin (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antifungals
  Natamycin
   D00884  Natamycin (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D00884  Natamycin (USP/INN); Pimaricin (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00884  Pimaricin
Antiinfectives [br08350.html]
 Antifungals
  D00884
BRITE hierarchy
Other DBs
CAS: 7681-93-8
PubChem: 7847948
ChEBI: 7488
DrugBank: DB00826
LigandBox: D00884
NIKKAJI: J3.429K
LinkDB All DBs
KCF data Show

ATOM        47
            1   C1y C    13.7782  -18.2793
            2   O2x O    12.5596  -17.5821
            3   C1y C    11.3432  -18.2826
            4   C1y C    11.3451  -19.6873
            5   C1y C    12.5634  -20.3916
            6   C1y C    13.7800  -19.6841
            7   C1y C    12.5738  -11.9903
            8   C1y C    12.5738  -13.3918
            9   C1y C    13.7913  -14.0890
            10  O2x O    14.9948  -13.3918
            11  C1z C    14.9948  -11.9903
            12  C1x C    13.7913  -11.2859
            13  C1b C    16.2008  -11.2859
            14  C1c C    17.4122  -11.9832
            15  C1b C    18.6233  -11.2790
            16  C1y C    19.8348  -11.9763
            17  C1y C    21.0462  -11.2719
            18  C2b C    22.2574  -11.9692
            19  C2b C    23.4617  -11.2648
            20  O6a O    25.8845  -11.2579
            21  C1b C    13.7932  -15.4905
            22  C1c C    15.0018  -16.1932
            23  C2b C    16.2078  -15.4834
            24  C2b C    17.4191  -16.1876
            25  C2b C    18.6304  -15.4834
            26  C2b C    19.8419  -16.1876
            27  C2b C    21.0531  -15.4834
            28  C2b C    22.2645  -16.1876
            29  C2b C    23.4688  -15.4834
            30  C2b C    24.6801  -16.1876
            31  C1b C    25.8913  -15.4834
            32  C1c C    25.8845  -14.0819
            33  O7a O    24.6663  -13.3908
            34  C7a C    24.6590  -11.9832
            35  O2x O    19.8277  -10.5748
            36  O1a O    17.4051  -13.3847
            37  O1a O    14.9824  -10.5888
            38  O2a O    14.9894  -17.5892
            39  C1a C    27.0957  -13.3776
            40  O1a O    11.3554  -11.2859
            41  C6a C    11.3554  -14.0819
            42  O1a O    10.1230  -20.3780
            43  N1a N    12.5652  -21.7930
            44  O1a O    14.9886  -20.3867
            45  C1a C    10.1276  -17.5870
            46  O6a O    10.1448  -13.3778
            47  O6a O    11.3475  -15.4834
BOND        50
            1    12   7 1
            2    24  25 1
            3     6   1 1
            4    25  26 2
            5    11  13 1
            6    26  27 1
            7    27  28 2
            8    13  14 1
            9    28  29 1
            10    1   2 1
            11   29  30 2
            12   14  15 1
            13   30  31 1
            14    2   3 1
            15   31  32 1
            16   15  16 1
            17   32  33 1
            18    3   4 1
            19   33  34 1
            20   16  17 1
            21   16  35 1
            22   17  35 1
            23    4   5 1
            24   14  36 1 #Down
            25   17  18 1
            26   11  37 1 #Down
            27    5   6 1
            28   18  19 2
            29   22  38 1 #Down
            30   19  34 1
            31   32  39 1 #Down
            32    7   8 1
            33    7  40 1 #Up
            34   34  20 2
            35    8  41 1 #Down
            36    1  38 1 #Down
            37    8   9 1
            38    4  42 1 #Down
            39    9  21 1
            40    5  43 1 #Up
            41    9  10 1
            42    6  44 1 #Up
            43   21  22 1
            44    3  45 1 #Up
            45   10  11 1
            46   41  46 2
            47   22  23 1
            48   41  47 1
            49   11  12 1
            50   23  24 2

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