| Entry |
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| Name |
Pioglitazone hydrochloride (JP18/USP);
Actos (TN) |
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| Product |
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| Generic |
PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (Accord Healthcare), PIOGLITAZONE (American Health Packaging), PIOGLITAZONE (Aphena Pharma Solutions - Tennessee), PIOGLITAZONE (AvKARE), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Coupler LLC), PIOGLITAZONE (Coupler LLC), PIOGLITAZONE (DIRECT RX), PIOGLITAZONE (Macleods Pharmaceuticals Limited), PIOGLITAZONE (Major Pharmaceuticals), PIOGLITAZONE (NorthStar RxLLC), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (Preferred Pharmaceuticals), PIOGLITAZONE (Preferred Pharmaceuticals), PIOGLITAZONE (Proficient Rx LP), PIOGLITAZONE (REMEDYREPACK), PIOGLITAZONE (REMEDYREPACK), PIOGLITAZONE (REMEDYREPACK), PIOGLITAZONE (Rising Pharma Holdings), PIOGLITAZONE (Sandoz), PIOGLITAZONE (Solco Healthcare LLC), PIOGLITAZONE (Teva Pharmaceuticals USA), PIOGLITAZONE (Zydus Lifesciences Limited), PIOGLITAZONE (Zydus Pharmaceuticals USA), PIOGLITAZONE HYDROCHLORIDE (A-S Medication Solutions), PIOGLITAZONE HYDROCHLORIDE (A-S Medication Solutions), PIOGLITAZONE HYDROCHLORIDE (A-S Medication Solutions), PIOGLITAZONE HYDROCHLORIDE (A-S Medication Solutions), PIOGLITAZONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PIOGLITAZONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PIOGLITAZONE HYDROCHLORIDE (Aurobindo Pharma Limited), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Chartwell RX), PIOGLITAZONE HYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONE HYDROCHLORIDE (QUALLENT PHARMACEUTICALS HEALTH LLC), PIOGLITAZONE HYDROCHLORIDE (REMEDYREPACK), PIOGLITAZONEHYDROCHLORIDE (Proficient Rx LP) |
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| Formula |
C19H20N2O3S. HCl
|
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| Exact mass |
392.0961
|
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| Mol weight |
392.90
|
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Therapeutic category: | 3969 |
| Product (DG00117): | D00945<JP/US> |
| Product (mixture): | D09744<JP/US> D09848<JP/US> D10159<JP/US> |
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| Efficacy |
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist |
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| Disease |
Type 2 diabetes mellitus [DS: H00409] |
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| Comment |
Thiazolidinedione derivative
|
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C8 [HSA: 1558]
|
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| Interaction |
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| Structure map |
| map07222 | Peroxisome proliferator-activated receptor (PPAR) agonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BG Thiazolidinediones
A10BG03 Pioglitazone
D00945 Pioglitazone hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
Antidiabetic Agents
Thiazolidinedione
Pioglitazone
D00945 Pioglitazone hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
396 Antidiabetic agents
3969 Others
D00945 Pioglitazone hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
DG00117 Pioglitazone
D00945 Pioglitazone hydrochloride
DG02044 Hypoglycemic agent
DG01683 Thiazolidinedione
DG00117 Pioglitazone
D00945 Pioglitazone hydrochloride
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00117 Pioglitazone
D00945 Pioglitazone hydrochloride
Drug classes [BR:br08332]
Antidiabetic agent
DG01683 Thiazolidinedione
D00945 Pioglitazone hydrochloride
DG02044 Hypoglycemic agent
D00945 Pioglitazone hydrochloride
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C3 (PPARG)
D00945 Pioglitazone hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00945 Pioglitazone hydrochloride
D00945 Pioglitazone hydrochloride tablets
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D00945
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00945
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D00945
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00945
Drug groups [BR:br08330]
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
DG00117 Pioglitazone
DG02044 Hypoglycemic agent
DG01683 Thiazolidinedione
DG00117 Pioglitazone
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00117 Pioglitazone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 C1y C 36.4918 -16.3605
2 C1b C 35.2747 -15.6584
3 C5x C 36.5002 -17.7636
4 S2x S 37.8328 -15.9323
5 C8y C 34.0636 -16.3605
6 N1x N 37.8315 -18.1968
7 O5x O 35.3724 -18.5929
8 C5x C 38.6556 -17.0654
9 C8x C 32.8527 -15.6584
10 C8x C 34.0636 -17.7589
11 O5x O 40.0558 -17.0643
12 C8x C 31.6415 -16.3605
13 C8x C 32.8527 -18.4610
14 C8y C 31.6415 -17.7589
15 O2a O 30.4304 -18.4610
16 C1b C 29.2134 -17.7589
17 C1b C 28.0023 -18.4610
18 C8y C 26.7911 -17.7589
19 C8x C 26.7911 -16.3664
20 N5x N 25.5800 -18.4668
21 C8x C 25.5800 -15.6701
22 C8x C 24.3689 -17.7647
23 C8y C 24.3689 -16.3664
24 C1b C 23.1580 -15.6701
25 C1a C 21.9409 -16.3664
26 X Cl 42.2119 -18.3454
BOND 27
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 3 7 2
7 4 8 1
8 5 9 2
9 5 10 1
10 8 11 2
11 9 12 1
12 10 13 2
13 12 14 2
14 14 15 1
15 15 16 1
16 16 17 1
17 17 18 1
18 18 19 2
19 18 20 1
20 19 21 1
21 20 22 2
22 21 23 2
23 23 24 1
24 24 25 1
25 6 8 1
26 13 14 1
27 22 23 1
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