KEGG   DRUG: Neostigmine methylsulfate
Entry
D00998                      Drug                                   
Name
Neostigmine methylsulfate (JP18/USP);
Bloxiverz (TN);
Prostigmin (TN)
Product
  Generic
Formula
C12H19N2O2. CH3SO4
Exact mass
334.1199
Mol weight
334.3886
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01719  Parasympathomimetic agent
Remark
Same as: C08200
Therapeutic category: 1233
ATC code: N07AA01 S01EB06
Chemical structure group: DG00987
Product (DG00987): D00995<JP> D00998<JP/US>
Product (mixture): D04114<JP> D09186<JP>
Efficacy
Parasympathomimetic, Acetylcholinesterase inhibitor
Comment
Physostigmine derivative
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA01 Neostigmine
      D00998  Neostigmine methylsulfate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB06 Neostigmine
      D00998  Neostigmine methylsulfate (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1233  Neostigmines
     D00998  Neostigmine methylsulfate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  62 General eye drops
   D00998  Neostigmine methylsulfate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Neostigmine
    D00998  Neostigmine methylsulfate (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00987  Neostigmine
     D00998  Neostigmine methylsulfate
  DG01719  Parasympathomimetic agent
   DG00987  Neostigmine
    D00998  Neostigmine methylsulfate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D00998  Neostigmine methylsulfate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00998  Neostigmine methylsulfate
  D00998  Neostigmine methylsulfate injection
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00987  Neostigmine
  DG01719  Parasympathomimetic agent
   DG00987  Neostigmine
Other DBs
CAS: 51-60-5
PubChem: 7848061
ChEBI: 7516
LigandBox: D00998
NIKKAJI: J262.808B
LinkDB
KCF data

ATOM        22
            1   C8y C    21.6932  -17.0217
            2   C8x C    22.9128  -16.3157
            3   C8x C    21.6932  -18.4279
            4   O7a O    20.4737  -16.3214
            5   C8y C    24.1207  -17.0217
            6   C8x C    22.9128  -19.1281
            7   C7a C    19.2600  -17.0274
            8   C8x C    24.1207  -18.4221
            9   N1d N    25.3402  -16.3157 #+
            10  N1c N    18.0405  -16.3274
            11  O6a O    19.2600  -18.4338
            12  C1a C    26.7988  -15.3937
            13  C1a C    24.6750  -15.2537
            14  C1a C    26.1630  -17.5234
            15  C1a C    16.8326  -17.0334
            16  C1a C    18.0405  -14.9210
            17  S4a S    32.7856  -17.4302
            18  O2a O    31.4201  -17.4243
            19  O1d O    32.7739  -18.7022
            20  O1d O    32.7272  -15.8138
            21  O1d O    34.1686  -17.4302 #-
            22  C1a C    30.6791  -16.3389
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 2
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16    6   8 1
            17   17  18 1
            18   17  19 2
            19   17  20 2
            20   17  21 1
            21   18  22 1

» Japanese version   » Back

DBGET integrated database retrieval system