| Entry |
|
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| Name |
Tetrahydrozoline hydrochloride (JAN/USP);
Tyzine (TN) |
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| Formula |
C13H16N2. HCl
|
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| Exact mass |
236.1080
|
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| Mol weight |
236.74
|
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
|
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| Remark |
| Product (mixture): | D04251<JP> |
|
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| Efficacy |
Vasoconstrictor, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Imidazoline derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AA Sympathomimetics, plain
R01AA06 Tetryzoline
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
R01AB Sympathomimetics, combinations excl. corticosteroids
R01AB03 Tetryzoline
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA02 Tetryzoline
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Cold-Cough
Tetrahydrozoline
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for ophthalmologic use
62 General eye drops
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
Agents for otolaryngologic use
70 Nasal sprays for inflammation
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Tetryzoline
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01030 Tetryzoline
D01023 Tetrahydrozoline hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01023 Tetrahydrozoline hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01030 Tetryzoline
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 16
1 C1y C 18.2700 -16.5200
2 C8y C 17.0800 -17.2900
3 C2y C 18.2700 -15.1200
4 C1x C 19.4600 -17.2200
5 C8y C 17.0800 -18.6900
6 C8x C 15.8200 -16.5900
7 N1x N 19.3900 -14.3500
8 N2x N 17.1500 -14.3500
9 C1x C 19.4600 -18.6200
10 C1x C 18.2700 -19.3200
11 C8x C 15.8200 -19.3200
12 C8x C 14.6300 -17.2900
13 C1x C 18.9700 -13.0200
14 C1x C 17.5700 -13.0200
15 C8x C 14.6300 -18.6900
16 X Cl 21.4900 -18.0600
BOND 17
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 8 14 1
14 11 15 2
15 9 10 1
16 12 15 1
17 13 14 1
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