KEGG   DRUG: Tolterodine tartrate
Entry
D01148                      Drug                                   
Name
Tolterodine tartrate (JAN/USP);
Detrol (TN);
Detrusitol (TN)
Product
  Generic
Formula
C22H31NO. C4H6O6
Exact mass
475.257
Mol weight
475.5745
Structure
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2590
ATC code: G04BD07
Chemical structure group: DG00480
Product (DG00480): D01148<JP/US>
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Comment
Treatment of urinary incontinence
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD07 Tolterodine
      D01148  Tolterodine tartrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Tolterodine
    D01148  Tolterodine tartrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01148  Tolterodine tartrate (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00480  Tolterodine
    D01148  Tolterodine tartrate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00480  Tolterodine
    D01148  Tolterodine tartrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00480  Tolterodine
     D01148  Tolterodine tartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D01148  Tolterodine tartrate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01148
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01148
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01148
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00480  Tolterodine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00480  Tolterodine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00480  Tolterodine
Other DBs
CAS: 124937-52-6
PubChem: 7848211
ChEBI: 32245
LigandBox: D01148
NIKKAJI: J1.208.248G
LinkDB
KCF data

ATOM        34
            1   O6a O    22.5567  -17.4447
            2   C6a C    23.7680  -16.7435
            3   C1c C    24.9791  -17.4447
            4   C1c C    26.1905  -16.7435
            5   C6a C    27.4018  -17.4447
            6   O6a O    28.6130  -16.7435
            7   O6a O    23.7680  -15.3410
            8   O1a O    24.9791  -18.8472
            9   O1a O    26.1905  -15.3410
            10  O6a O    27.4018  -18.8472
            11  C1c C     9.8068  -16.8754
            12  N1c N    11.0205  -17.5762
            13  C1b C    12.2344  -16.8754
            14  C1b C    13.4481  -17.5762
            15  C1c C    14.6618  -16.8754
            16  C8y C    15.8756  -17.5762
            17  C8x C    17.0894  -16.8754
            18  C8y C    18.3032  -17.5762
            19  C1a C    19.5170  -16.8754
            20  C1a C     8.5930  -17.5762
            21  C1a C     9.8068  -15.4739
            22  C1c C    11.0205  -18.9775
            23  C1a C     9.7899  -19.6882
            24  C1a C    12.2175  -19.6687
            25  C8y C    14.6618  -15.4740
            26  C8y C    15.8756  -18.9774
            27  C8x C    18.3032  -18.9776
            28  C8x C    17.1102  -19.6905
            29  O1a O    14.6827  -19.6663
            30  C8x C    15.8607  -14.7817
            31  C8x C    15.8606  -13.3802
            32  C8x C    14.6468  -12.6795
            33  C8x C    13.4479  -13.3718
            34  C8x C    13.4480  -14.7733
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     3   8 1 #Up
            8     4   9 1 #Up
            9     5  10 2
            10   11  12 1
            11   12  13 1
            12   13  14 1
            13   15  14 1 #Down
            14   15  16 1
            15   16  17 1
            16   17  18 2
            17   18  19 1
            18   11  20 1
            19   11  21 1
            20   12  22 1
            21   22  23 1
            22   22  24 1
            23   15  25 1
            24   16  26 2
            25   18  27 1
            26   26  28 1
            27   28  27 2
            28   26  29 1
            29   25  30 2
            30   30  31 1
            31   31  32 2
            32   32  33 1
            33   33  34 2
            34   25  34 1

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