KEGG   DRUG: FebuxostatHelp
Entry
D01206                      Drug                                   

Name
Febuxostat (JAN/USAN/INN);
Uloric (TN);
Feburic (TN)
Product
Formula
C16H16N2O3S
Exact mass
316.0882
Mol weight
316.3748
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01503  Xanthine dehydrogenase inhibitor
Remark
Therapeutic category: 3949
ATC code: M04AA03
Chemical structure group: DG02878
Product (DG02878): D01206<JP/US>
Efficacy
Gout suppressant, Uric acid biosynthesis inhibitor, Xanthine oxidase inhibitor
  Disease
Gout [DS:H01532]
Comment
Management of hyperuricemia in patients with gout
Target
XDH [HSA:7498] [KO:K00106]
  Pathway
hsa00230  Purine metabolism
hsa04146  Peroxisome
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AA Preparations inhibiting uric acid production
     M04AA03 Febuxostat
      D01206  Febuxostat (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antigout Agents
  Febuxostat
   D01206  Febuxostat (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3949  Others
     D01206  Febuxostat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Xanthine dehydrogenase/oxidase
    XDH
     D01206  Febuxostat (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01206
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01206
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01206
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01206
BRITE hierarchy
Other DBs
CAS: 144060-53-7
PubChem: 7848269
ChEBI: 31596
ChEMBL: CHEMBL1164729
PDB-CCD: TEI[PDBj]
LigandBox: D01206
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8x C    16.2448  -15.8562
            2   C8y C    16.2448  -17.2564
            3   C8y C    17.4603  -17.9563
            4   C8x C    18.6686  -17.2564
            5   C8y C    18.6686  -15.8562
            6   C8x C    17.4603  -15.1562
            7   C8y C    19.8816  -15.1570
            8   C3b C    17.4620  -19.3565
            9   O2a O    15.0325  -17.9569
            10  C1b C    13.8197  -17.2575
            11  C1c C    12.6075  -17.9582
            12  C1a C    11.3946  -17.2587
            13  C1a C    12.6082  -19.3584
            14  S2x S    21.2083  -15.5955
            15  C8y C    22.0380  -14.4677
            16  C8y C    21.2218  -13.3302
            17  N5x N    19.8877  -13.7548
            18  C1a C    21.6625  -12.0012
            19  C6a C    23.4381  -14.4761
            20  O6a O    24.1311  -15.6927
            21  O6a O    24.1455  -13.2676
            22  N3a N    17.4539  -20.7566
BOND        23
            1     9  10 1
            2     5   6 2
            3    10  11 1
            4     6   1 1
            5    11  12 1
            6    11  13 1
            7     5   7 1
            8     1   2 2
            9     3   8 1
            10    2   3 1
            11    7  14 1
            12   14  15 1
            13   15  16 2
            14   16  17 1
            15   17   7 2
            16   16  18 1
            17    3   4 2
            18   15  19 1
            19    2   9 1
            20   19  20 2
            21    4   5 1
            22   19  21 1
            23    8  22 3

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