| Entry |
|
|---|
| Name |
Solifenacin succinate (JAN/USAN/INN);
Vesicare (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C23H26N2O2. C4H6O4
|
|---|
| Exact mass |
480.226
|
|---|
| Mol weight |
480.5528
|
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| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2590 |
| Product (DG00481): | D01269<JP/US> |
|
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| Efficacy |
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Comment |
Treatment for relief of symptoms of urinary frequency, urinary urgency, or urge urinary incontinence (UUI) associated with an overactive bladder
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Urinary antispasmodics
G04BD08 Solifenacin
D01269 Solifenacin succinate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Genitourinary Agents
Antispasmodics, Urinary
Solifenacin
D01269 Solifenacin succinate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D01269 Solifenacin succinate (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM3
D01269 Solifenacin succinate (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01269
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01269
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01269
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| Other DBs |
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| LinkDB |
 |
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| KCF data |
ATOM 35
1 C6a C 27.3377 -15.6723
2 C1b C 26.1211 -16.3800
3 O6a O 28.5603 -16.3800
4 O6a O 27.3377 -14.2742
5 C1b C 24.9102 -15.6781
6 C6a C 23.6994 -16.3858
7 O6a O 22.4826 -15.6840
8 O6a O 23.6994 -17.7839
9 C1y C 18.3613 -14.7461
10 C1x C 18.3613 -13.3364
11 C1y C 17.1446 -15.4538
12 C1x C 19.5662 -15.4538
13 C1x C 19.0456 -14.5531
14 C1x C 17.8349 -16.6589
15 C1x C 20.2564 -16.6589
16 N1y N 19.0398 -15.9627
17 C1x C 12.3002 -12.6575
18 C1x C 13.5080 -13.3573
19 N1y N 13.5080 -14.7568
20 C1y C 12.3002 -15.4565
21 C8y C 11.0852 -13.3573
22 C8y C 11.0852 -14.7568
23 C8x C 9.8734 -15.4565
24 C8x C 8.6613 -14.7568
25 C8x C 8.6613 -13.3573
26 C8x C 9.8734 -12.6575
27 C8y C 12.3020 -16.8560
28 C8x C 13.5154 -17.5532
29 C8x C 13.5171 -18.9527
30 C8x C 12.3061 -19.6540
31 C8x C 11.0932 -18.9558
32 C8x C 11.0913 -17.5563
33 C7a C 14.7205 -15.4555
34 O7a O 15.9321 -14.7549
35 O6a O 14.7216 -16.8550
BOND 38
1 6 7 1
2 6 8 2
3 1 2 1
4 1 3 1
5 1 4 2
6 2 5 1
7 5 6 1
8 21 17 1
9 17 18 1
10 18 19 1
11 19 20 1
12 20 22 1
13 9 10 1
14 21 22 2
15 22 23 1
16 23 24 2
17 24 25 1
18 25 26 2
19 26 21 1
20 9 11 1
21 20 27 1 #Up
22 9 12 1
23 10 13 1
24 11 14 1
25 12 15 1
26 13 16 1
27 27 28 2
28 28 29 1
29 29 30 2
30 30 31 1
31 31 32 2
32 32 27 1
33 14 16 1
34 19 33 1
35 15 16 1
36 33 34 1
37 33 35 2
38 11 34 1 #Down
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