KEGG   DRUG: Cyclofenil
Entry
D01281                      Drug                                   
Name
Cyclofenil (JAN/INN);
Sexovid (TN)
Formula
C23H24O4
Exact mass
364.1675
Mol weight
364.43
Structure
Simcomp
Class
Hormonal agent
 DG01619  Estrogen receptor antagonist/modulator
Remark
Therapeutic category: 2499
ATC code: G03GB01
Product: D01281<JP>
Efficacy
Ovulation inducing agent, Gonadotropin stimulant
Target
LHCGR [HSA:3973] [KO:K04248]
FSHR [HSA:2492] [KO:K04247]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04913  Ovarian steroidogenesis
hsa04917  Prolactin signaling pathway
Interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03G GONADOTROPINS AND OTHER OVULATION STIMULANTS
    G03GB Ovulation stimulants, synthetic
     G03GB01 Cyclofenil
      D01281  Cyclofenil (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D01281  Cyclofenil (JAN/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01619  Estrogen receptor antagonist/modulator
   D01281  Cyclofenil
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Follicle stimulating hormone
    FSHR
     D01281  Cyclofenil (JAN/INN) <JP>
   Lutropin-choriogonadotropic hormone
    LHCGR
     D01281  Cyclofenil (JAN/INN) <JP>
Other DBs
CAS: 2624-43-3
PubChem: 7848344
ChEBI: 31446
LigandBox: D01281
NIKKAJI: J3.393F
LinkDB
KCF data

ATOM        27
            1   C2y C    24.5158  -14.3724
            2   C2c C    24.5087  -15.7727
            3   C8y C    23.2925  -16.4668
            4   C8y C    25.7179  -16.4790
            5   C8x C    22.0843  -15.7608
            6   C8x C    20.8680  -16.4549
            7   C8y C    20.8610  -17.8553
            8   C8x C    22.0701  -18.5616
            9   C8x C    23.2864  -17.8675
            10  C8x C    25.7033  -17.8726
            11  C8x C    26.9125  -18.5789
            12  C8y C    28.1287  -17.8848
            13  C8x C    28.1358  -16.4844
            14  C8x C    26.9266  -15.7782
            15  O7a O    19.6447  -18.5492
            16  O7a O    29.3379  -18.5911
            17  C7a C    18.4354  -17.8429
            18  C1a C    17.2192  -18.5370
            19  O6a O    18.4426  -16.4425
            20  C7a C    30.5541  -17.8970
            21  C1a C    31.7634  -18.6033
            22  O6a O    30.4913  -16.4968
            23  C1x C    25.7320  -13.6783
            24  C1x C    25.7391  -12.2779
            25  C1x C    24.5299  -11.5716
            26  C1x C    23.3135  -12.2657
            27  C1x C    23.3066  -13.6661
BOND        29
            1    12  13 1
            2    13  14 2
            3    14   4 1
            4     5   6 1
            5     7  15 1
            6     6   7 2
            7    12  16 1
            8     7   8 1
            9    15  17 1
            10    8   9 2
            11   17  18 1
            12    9   3 1
            13   17  19 2
            14    2   3 1
            15   16  20 1
            16    1   2 2
            17   20  21 1
            18    2   4 1
            19   20  22 2
            20    3   5 2
            21    4  10 2
            22   10  11 1
            23   11  12 2
            24    1  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27   1 1

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