| Entry |
|
|---|
| Name |
Midodrine hydrochloride (JAN/USP);
Pro-Amatine (TN) |
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| Product |
|
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| Generic |
MIDODRINE HCL (Cardinal Health 107), MIDODRINE HYDROCHLORIDE (Advagen Pharma Limited), MIDODRINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), MIDODRINE HYDROCHLORIDE (Alembic Pharmaceuticals), MIDODRINE HYDROCHLORIDE (American Health Packaging), MIDODRINE HYDROCHLORIDE (Apotex Corp), MIDODRINE HYDROCHLORIDE (Aurobindo Pharma Limited), MIDODRINE HYDROCHLORIDE (AvKARE), MIDODRINE HYDROCHLORIDE (AvPAK), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Cardinal Health 107), MIDODRINE HYDROCHLORIDE (Cardinal Health 107), MIDODRINE HYDROCHLORIDE (Drug Ocean LLC), MIDODRINE HYDROCHLORIDE (Golden State Medical Supply), MIDODRINE HYDROCHLORIDE (Lifestar Pharma LLC), MIDODRINE HYDROCHLORIDE (Major Pharmaceuticals), MIDODRINE HYDROCHLORIDE (McKesson Corporation DBA SKY Packaging), MIDODRINE HYDROCHLORIDE (Mylan Institutional), MIDODRINE HYDROCHLORIDE (Mylan Pharmaceuticals), MIDODRINE HYDROCHLORIDE (NCS HealthCare of KY), MIDODRINE HYDROCHLORIDE (NCS HealthCare of KY), MIDODRINE HYDROCHLORIDE (Novugen Pharma (USA) LLC), MIDODRINE HYDROCHLORIDE (Par Pharmaceutical), MIDODRINE HYDROCHLORIDE (Proficient Rx LP), MIDODRINE HYDROCHLORIDE (Rising Pharmaceuticals), MIDODRINE HYDROCHLORIDE (TruPharma), MIDODRINE HYDROCHLORIDE (Upsher-Smith laboratories), MIDODRINE HYDROCHLORIDE (Xiromed), MIDODRINE HYDROCHLORIDE (Zydus Lifesciences Limited), MIDODRINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)) |
|---|
| Formula |
C12H18N2O4. HCl
|
|---|
| Exact mass |
290.1033
|
|---|
| Mol weight |
290.74
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 2160 |
| Product (DG00224): | D01307<JP/US> |
|
|---|
| Efficacy |
Antihypotensive, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Phenethylamine derivative
Active form of prodrug: Deglymidodrine [CPD: C21521]
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA17 Midodrine
D01307 Midodrine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Alpha-adrenergic Agonists
Midodrine
D01307 Midodrine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
216 Vasoconstrictors
2160 Vasoconstrictors
D01307 Midodrine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG00224 Midodrine
D01307 Midodrine hydrochloride
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG00224 Midodrine
D01307 Midodrine hydrochloride
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00224 Midodrine
D01307 Midodrine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01307 Midodrine hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01307
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG00224 Midodrine
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG00224 Midodrine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00224 Midodrine
Prodrugs [br08324.html]
DG00224
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 19
1 X Cl 27.9649 -19.4803
2 C8y C 17.4300 -16.0300
3 C8x C 17.4300 -17.4300
4 C8x C 18.6200 -18.1300
5 C8y C 19.8800 -17.4300
6 C8y C 19.8800 -16.0300
7 C8x C 18.6200 -15.3300
8 C1c C 21.0700 -15.3300
9 C1b C 22.2600 -16.0300
10 O1a O 21.0700 -13.9300
11 N1b N 23.4500 -15.3300
12 C5a C 24.7100 -16.0300
13 C1b C 25.9000 -15.3300
14 N1a N 27.0900 -16.0300
15 O5a O 24.7100 -17.4300
16 O2a O 16.1700 -15.3300
17 C1a C 14.9800 -16.0300
18 O2a O 21.0700 -18.1300
19 C1a C 21.0700 -19.5300
BOND 18
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 6 8 1
8 8 9 1
9 8 10 1
10 9 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 12 15 2
15 2 16 1
16 16 17 1
17 5 18 1
18 18 19 1
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