KEGG   DRUG: CladribineHelp
Entry
D01370                      Drug                                   

Name
Cladribine (JAN/USAN/INN);
Leustatin (TN)
Product
  Generic
Formula
C10H12ClN5O3
Exact mass
285.0629
Mol weight
285.687
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
Remark
Therapeutic category: 4291
ATC code: L01BB04
Product: D01370<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Hairy-cell leukemia [DS:H00006]
Target
RRM1 [HSA:6240] [KO:K10807]
DNA polymerase
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
Interaction
Drug interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BB Purine analogues
     L01BB04 Cladribine
      D01370  Cladribine (JAN/USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D01370  Cladribine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Ribonucleoside-diphosphate reductase
    RRM1
     D01370  Cladribine (JAN/USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D01370
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01370
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01370
BRITE hierarchy
Other DBs
CAS: 4291-63-8
PubChem: 7848433
ChEBI: 567361
ChEMBL: CHEMBL1619
DrugBank: DB00242
PDB-CCD: CL9[PDBj]
LigandBox: D01370
NIKKAJI: J446.344G
LinkDB All DBs
KCF data Show

ATOM        19
            1   C1y C    13.2977  -19.5392
            2   C1x C    14.6838  -19.5392
            3   C1y C    15.1121  -18.2209
            4   O2x O    13.9907  -17.4062
            5   C1y C    12.8694  -18.2209
            6   N5x N    17.5130  -19.6070
            7   C8y C    17.5130  -18.2209
            8   N4y N    16.3126  -17.5278
            9   C1b C    11.6689  -17.5278
            10  O1a O    10.4685  -18.2209
            11  O1a O    12.4829  -20.6606
            12  C8y C    18.7133  -20.3000
            13  N5x N    19.9138  -19.6070
            14  C8y C    19.9138  -18.2209
            15  C8y C    18.7133  -17.5278
            16  C8x C    16.7284  -16.1436
            17  N5x N    18.2975  -16.1432
            18  X   Cl   18.7133  -21.6877
            19  N1a N    21.1159  -17.5266
BOND        21
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     6   7 1
            7     7   8 1
            8     3   8 1 #Up
            9     5   9 1 #Up
            10    9  10 1
            11    1  11 1 #Down
            12    6  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16    7  15 2
            17    8  16 1
            18   15  17 1
            19   16  17 2
            20   12  18 1
            21   14  19 1

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