KEGG   DRUG: AmpiroxicamHelp
Entry
D01397                      Drug                                   

Name
Ampiroxicam (JP17/INN);
Flucam (TN)
Formula
C20H21N3O7S
Exact mass
447.11
Mol weight
447.4616
Structure
Mol fileKCF fileDB search
Class
Anti-inflammatory
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01910  Antiinflammatory drug, oxicams
 DG01910  Antiinflammatory drug, oxicams
Enzyme substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1149
Product: D01397<JP>
Efficacy
Analgesic, Anti-inflammatory, Antirheumatic, COX inhibitor
Comment
Oxicams
Active form of prodrug: Piroxicam [DR:D00127]
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01397  Ampiroxicam (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01397  Ampiroxicam (JP17/INN) <JP>
    PTGS2 (COX2)
     D01397  Ampiroxicam (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01397  Ampiroxicam
  D01397  Ampiroxicam capsules
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D01397
 Anesthetics, analgesics and anti-inflammatory drugs
  D01397
Prodrugs [br08324.html]
 D01397
BRITE hierarchy
Other DBs
CAS: 99464-64-9
PubChem: 7848460
ChEBI: 31210
ChEMBL: CHEMBL1566249
LigandBox: D01397
NIKKAJI: J366.317E
LinkDB All DBs
KCF data Show

ATOM        31
            1   C8y C    27.9963  -14.0121
            2   N5x N    29.1858  -14.6984
            3   C8x C    30.3750  -14.0113
            4   C8x C    30.3745  -12.6380
            5   C8x C    29.1849  -11.9517
            6   C8x C    27.9959  -12.6388
            7   C8y C    22.0186  -14.7322
            8   C8y C    22.0186  -16.1207
            9   C8y C    23.2177  -14.0254
            10  C8x C    20.8133  -14.0445
            11  S2x S    23.2303  -16.8149
            12  C8x C    20.8133  -16.8211
            13  C8y C    24.4294  -14.7260
            14  O2a O    23.2115  -12.6560
            15  C8x C    19.6269  -14.7322
            16  N4y N    24.4420  -16.1269
            17  C8x C    19.6269  -16.1207
            18  C5a C    25.6157  -14.0318
            19  C1a C    25.6283  -16.8085
            20  O5a O    25.6094  -12.6624
            21  C1c C    22.0256  -11.9761
            22  O7a O    20.8437  -12.6549
            23  C7a C    19.6616  -11.9761
            24  O7a O    18.4798  -12.6549
            25  C1b C    17.2979  -11.9761
            26  C1a C    16.1158  -12.6549
            27  O6a O    19.6541  -10.6112
            28  C1a C    22.0250  -10.6132
            29  N1b N    26.8096  -14.7130
            30  O3c O    22.2404  -17.8048
            31  O3c O    24.2203  -17.8048
BOND        33
            1     7  10 1
            2     8  11 1
            3     8  12 1
            4     9  13 2
            5     9  14 1
            6    10  15 2
            7    11  16 1
            8    12  17 2
            9    13  18 1
            10   16  19 1
            11   18  20 2
            12   13  16 1
            13   15  17 1
            14    2   3 1
            15   14  21 1
            16    3   4 2
            17   21  22 1
            18    4   5 1
            19   22  23 1
            20    5   6 2
            21   23  24 1
            22    6   1 1
            23   24  25 1
            24   25  26 1
            25    1   2 2
            26   23  27 2
            27    7   8 2
            28   21  28 1
            29    7   9 1
            30   18  29 1
            31   29   1 1
            32   11  30 2
            33   11  31 2

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