KEGG   DRUG: FosfluconazoleHelp
Entry
D01429                      Drug                                   

Name
Fosfluconazole (JAN/INN);
Prodif (TN)
Formula
C13H13F2N6O4P
Exact mass
386.0704
Mol weight
386.2507
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antifungal
 DG01523  Triazole antifungal
Enzyme substrate
 DG01633  CYP3A substrate
Enzyme inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
 DG02852  CYP3A inhibitor
  DG01522  CYP3A4 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Therapeutic category: 6290
ATC code: D01AC15 J02AC01
Chemical structure group: DG00371
Product (DG00371): D00322<JP/US> D01429<JP>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Triazole derivative
Active form of prodrug: Fluconazole [DR:D00322]
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC15 Fluconazole
      D01429  Fosfluconazole (JAN/INN) <JP>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole derivatives
     J02AC01 Fluconazole
      D01429  Fosfluconazole (JAN/INN) <JP>
USP drug classification [BR:br08302]
 Antifungals
  Fluconazole
   D01429  Fosfluconazole (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D01429  Fosfluconazole (JAN/INN)
Antiinfectives [br08350.html]
 Antifungals
  D01429
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01429
Prodrugs [br08324.html]
 D01429
Prodrugs [br08324.html]
 DG00371
BRITE hierarchy
Other DBs
CAS: 194798-83-9
PubChem: 7848492
ChEBI: 31634
ChEMBL: CHEMBL1908301
DrugBank: DB00196
LigandBox: D01429
NIKKAJI: J1.645.469I
LinkDB All DBs
KCF data Show

ATOM        26
            1   C8x C    30.1700  -12.4600
            2   C8x C    30.1700  -13.8600
            3   C8y C    31.2900  -14.5600
            4   C8y C    32.4800  -13.8600
            5   C8x C    32.4800  -12.4600
            6   C8y C    31.2900  -11.7600
            7   X   F    31.2900  -10.4300
            8   X   F    33.7400  -14.5600
            9   C1d C    31.2900  -16.7300
            10  C1b C    30.1000  -17.4300
            11  C1b C    32.4800  -17.3600
            12  N4y N    28.9800  -16.7300
            13  N4y N    33.6700  -16.7300
            14  C8x C    28.9800  -15.3300
            15  C8x C    33.6700  -15.3300
            16  N5x N    27.6500  -14.9100
            17  C8x C    26.8100  -16.0300
            18  N5x N    27.6500  -17.1500
            19  N5x N    34.9300  -17.1500
            20  C8x C    35.7700  -16.0300
            21  N5x N    34.9300  -14.9100
            22  O2b O    31.2900  -18.0600
            23  P1b P    31.2900  -19.4600
            24  O1c O    31.2900  -20.7900
            25  O1c O    32.6900  -19.4600
            26  O1c O    29.9600  -19.4600
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     4   8 1
            9     3   9 1
            10    9  10 1
            11    9  11 1
            12   10  12 1
            13   11  13 1
            14   12  14 1
            15   13  15 1
            16   14  16 2
            17   16  17 1
            18   17  18 2
            19   12  18 1
            20   13  19 1
            21   19  20 2
            22   20  21 1
            23   15  21 2
            24    9  22 1
            25   22  23 1
            26   23  24 2
            27   23  25 1
            28   23  26 1

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