KEGG   DRUG: Fondaparinux sodiumHelp
Entry
D01844                      Drug                                   

Name
Fondaparinux sodium (JAN/USAN/INN);
Arixtra (TN)
Product
  Generic
Formula
C31H43N3O49S8. 10Na
Exact mass
1726.7708
Mol weight
1728.0815
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01662  Factor Xa inhibitor
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
Remark
Therapeutic category: 3339
ATC code: B01AX05
Product: D01844<JP/US>
Efficacy
Antithrombotic, Factor Xa inhibitor
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Drug interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AX Other antithrombotic agents
     B01AX05 Fondaparinux
      D01844  Fondaparinux sodium (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Anticoagulants
   Fondaparinux
    D01844  Fondaparinux sodium (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3339  Others
     D01844  Fondaparinux sodium (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Immune system
   Complement and coagulation
    F10
     D01844  Fondaparinux sodium (JAN/USAN/INN) <JP/US>
    SERPINC1 (AT3)
     D01844  Fondaparinux sodium (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01844
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01844
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01844
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01844
BRITE hierarchy
Other DBs
CAS: 114870-03-0
PubChem: 7848906
ChEBI: 31632
ChEMBL: CHEMBL1200644
DrugBank: DB00569
LigandBox: D01844
NIKKAJI: J1.878.798I
LinkDB All DBs
KCF data Show

ATOM        101
            1   C1y C    19.9001  -15.0491
            2   C1y C    19.9001  -16.4350
            3   C1y C    21.1004  -17.1280
            4   C1y C    22.3007  -16.4350
            5   O2x O    22.3007  -15.0491
            6   C1y C    21.1004  -14.3561
            7   O2a O    23.5010  -17.1280
            8   C1y C    24.7012  -16.4350
            9   C1y C    24.7012  -15.0491
            10  O1a O    23.5010  -14.3561
            11  C1y C    25.9015  -17.1280
            12  O2x O    27.1018  -16.4350
            13  C1y C    27.1018  -15.0491
            14  C1y C    25.9015  -14.3561
            15  O2a O    28.3020  -17.1280
            16  C1y C    29.5023  -16.4350
            17  C1y C    29.5023  -15.0491
            18  O2a O    28.3020  -14.3561
            19  C1y C    30.7026  -17.1280
            20  C1y C    31.9029  -16.4350
            21  O2x O    31.9029  -15.0491
            22  C1y C    30.7026  -14.3561
            23  O2a O    33.1032  -17.1280
            24  C1y C    34.3034  -16.4350
            25  C1y C    34.3034  -15.0491
            26  O1a O    33.1032  -14.3561
            27  C1y C    35.5037  -17.1280
            28  O2x O    36.7040  -16.4350
            29  C1y C    36.7040  -15.0491
            30  C1y C    35.5037  -14.3561
            31  O1a O    37.9042  -17.1280
            32  C1y C    39.1045  -16.4350
            33  C1y C    39.1045  -15.0491
            34  O2a O    37.9042  -14.3561
            35  C1y C    40.3048  -17.1280
            36  C1y C    41.5050  -16.4350
            37  O2x O    41.5050  -15.0491
            38  C1y C    40.3048  -14.3561
            39  O1a O    18.6999  -17.1280
            40  C1b C    21.1004  -12.9703
            41  O1a O    25.9015  -12.9704
            42  C1b C    30.7026  -12.9701
            43  O2a O    35.5037  -12.9701
            44  C1b C    40.3048  -12.9705
            45  O1a O    18.6999  -14.3561
            46  N1b N    21.1004  -18.5138
            47  C6a C    25.9015  -19.2067
            48  N1b N    30.7026  -18.8605
            49  O2a O    42.7172  -17.1350
            50  N1b N    40.3048  -18.8601
            51  C6a C    35.5037  -18.5140
            52  C1a C    43.9069  -16.4481
            53  S4a S    19.8835  -19.2165
            54  O1d O    18.6832  -19.9094
            55  O1d O    20.5765  -20.4167 #-
            56  O1d O    19.1905  -18.0164
            57  O2a O    22.2840  -12.2868
            58  S4a S    23.4842  -11.5938
            59  O1d O    24.6846  -10.9008
            60  O1d O    24.4689  -12.5787
            61  O1d O    22.5093  -10.6187 #-
            62  O2a O    41.4818  -12.2908
            63  S4a S    42.6820  -11.5979
            64  O1d O    43.8822  -10.9049
            65  O1d O    41.9874  -10.3949 #-
            66  O1d O    43.3733  -12.7951
            67  S4a S    36.6954  -12.2822
            68  O2a O    31.9089  -12.2737
            69  S4a S    33.1091  -11.5807
            70  O1d O    34.3094  -10.8877
            71  O1d O    32.4247  -10.3947 #-
            72  O1d O    33.8100  -12.7952
            73  O1d O    37.8956  -11.5892 #-
            74  O1d O    35.9942  -11.0673
            75  O1d O    37.3796  -13.4678
            76  S4a S    28.3020  -18.5140
            77  O1d O    28.3020  -19.8999 #-
            78  O1d O    29.6711  -18.5140
            79  O1d O    26.8992  -18.5140
            80  O6a O    36.6954  -19.2019 #-
            81  O6a O    34.2948  -19.2120
            82  O6a O    27.1224  -19.9118
            83  O6a O    24.7219  -19.8879 #-
            84  S4a S    31.9089  -19.5569
            85  S4a S    41.4818  -19.5398
            86  O1d O    33.1091  -20.2499 #-
            87  O1d O    31.2125  -20.7633
            88  O1d O    32.5982  -18.3628
            89  O1d O    42.6820  -20.2328
            90  O1d O    40.7757  -20.7633
            91  O1d O    42.1610  -18.3627 #-
            92  Z   Na   20.5931  -10.6140 #+
            93  Z   Na   22.1177  -20.4543 #+
            94  Z   Na   40.0658  -10.4061 #+
            95  Z   Na   30.3641  -10.4061 #+
            96  Z   Na   37.5711  -10.4754 #+
            97  Z   Na   28.2852  -20.9394 #+
            98  Z   Na   37.6404  -19.9692 #+
            99  Z   Na   24.4738  -20.9394 #+
            100 Z   Na   43.6693  -18.3754 #+
            101 Z   Na   34.5220  -20.5236 #+
BOND        95
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1 #Down
            8     8   7 1 #Up
            9     8   9 1
            10    9  10 1 #Down
            11    8  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  14 1
            16   16  15 1 #Up
            17   16  17 1
            18   17  18 1 #Down
            19   13  18 1 #Down
            20   16  19 1
            21   20  19 1
            22   20  21 1
            23   21  22 1
            24   17  22 1
            25   20  23 1 #Down
            26   24  23 1 #Up
            27   24  25 1
            28   25  26 1 #Down
            29   24  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   25  30 1
            34   32  31 1 #Up
            35   32  33 1
            36   33  34 1 #Down
            37   29  34 1 #Down
            38   32  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   33  38 1
            43    2  39 1 #Up
            44    6  40 1 #Up
            45   14  41 1 #Up
            46   22  42 1 #Up
            47   30  43 1 #Up
            48   38  44 1 #Up
            49    1  45 1 #Down
            50    3  46 1 #Down
            51   11  47 1 #Down
            52   19  48 1 #Down
            53   36  49 1 #Down
            54   35  50 1 #Down
            55   27  51 1 #Up
            56   49  52 1
            57   46  53 1
            58   53  54 2
            59   53  55 1
            60   53  56 2
            61   40  57 1
            62   57  58 1
            63   58  59 2
            64   58  60 2
            65   58  61 1
            66   44  62 1
            67   62  63 1
            68   63  64 2
            69   63  65 1
            70   63  66 2
            71   43  67 1
            72   42  68 1
            73   68  69 1
            74   69  70 2
            75   69  71 1
            76   69  72 2
            77   67  73 1
            78   67  74 2
            79   67  75 2
            80   15  76 1
            81   76  77 1
            82   76  78 2
            83   76  79 2
            84   51  80 1
            85   51  81 2
            86   47  82 2
            87   47  83 1
            88   48  84 1
            89   50  85 1
            90   84  86 1
            91   84  87 2
            92   84  88 2
            93   85  89 2
            94   85  90 2
            95   85  91 1

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