KEGG   DRUG: Fondaparinux sodium
Entry
D01844                      Drug                                   

Name
Fondaparinux sodium (JAN/USP/INN);
Arixtra (TN)
Product
  Generic
Formula
C31H43N3O49S8. 10Na
Exact mass
1726.7708
Mol weight
1728.0815
Structure
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
Remark
Therapeutic category: 3339
ATC code: B01AX05
Product: D01844<JP/US>
Efficacy
Antithrombotic, Factor Xa inhibitor
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AX Other antithrombotic agents
     B01AX05 Fondaparinux
      D01844  Fondaparinux sodium (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Factor Xa Inhibitors, Indirect
    Fondaparinux
     D01844  Fondaparinux sodium (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3339  Others
     D01844  Fondaparinux sodium (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    F10
     D01844  Fondaparinux sodium (JAN/USP/INN) <JP/US>
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D01844  Fondaparinux sodium (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01844
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01844
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01844
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01844
Other DBs
CAS: 114870-03-0
PubChem: 7848906
ChEBI: 31632
ChEMBL: CHEMBL1200644
DrugBank: DB00569
LigandBox: D01844
NIKKAJI: J1.878.798I
LinkDB
KCF data

ATOM        101
            1   C1y C    19.9001  -15.0491
            2   C1y C    19.9001  -16.4350
            3   C1y C    21.1004  -17.1280
            4   C1y C    22.3007  -16.4350
            5   O2x O    22.3007  -15.0491
            6   C1y C    21.1004  -14.3561
            7   O2a O    23.5010  -17.1280
            8   C1y C    24.7012  -16.4350
            9   C1y C    24.7012  -15.0491
            10  O1a O    23.5010  -14.3561
            11  C1y C    25.9015  -17.1280
            12  O2x O    27.1018  -16.4350
            13  C1y C    27.1018  -15.0491
            14  C1y C    25.9015  -14.3561
            15  O2a O    28.3020  -17.1280
            16  C1y C    29.5023  -16.4350
            17  C1y C    29.5023  -15.0491
            18  O2a O    28.3020  -14.3561
            19  C1y C    30.7026  -17.1280
            20  C1y C    31.9029  -16.4350
            21  O2x O    31.9029  -15.0491
            22  C1y C    30.7026  -14.3561
            23  O2a O    33.1032  -17.1280
            24  C1y C    34.3034  -16.4350
            25  C1y C    34.3034  -15.0491
            26  O1a O    33.1032  -14.3561
            27  C1y C    35.5037  -17.1280
            28  O2x O    36.7040  -16.4350
            29  C1y C    36.7040  -15.0491
            30  C1y C    35.5037  -14.3561
            31  O1a O    37.9042  -17.1280
            32  C1y C    39.1045  -16.4350
            33  C1y C    39.1045  -15.0491
            34  O2a O    37.9042  -14.3561
            35  C1y C    40.3048  -17.1280
            36  C1y C    41.5050  -16.4350
            37  O2x O    41.5050  -15.0491
            38  C1y C    40.3048  -14.3561
            39  O1a O    18.6999  -17.1280
            40  C1b C    21.1004  -12.9703
            41  O1a O    25.9015  -12.9704
            42  C1b C    30.7026  -12.9701
            43  O2a O    35.5037  -12.9701
            44  C1b C    40.3048  -12.9705
            45  O1a O    18.6999  -14.3561
            46  N1b N    21.1004  -18.5138
            47  C6a C    25.9015  -19.2067
            48  N1b N    30.7026  -18.8605
            49  O2a O    42.7172  -17.1350
            50  N1b N    40.3048  -18.8601
            51  C6a C    35.5037  -18.5140
            52  C1a C    43.9069  -16.4481
            53  S4a S    19.8835  -19.2165
            54  O1d O    18.6832  -19.9094
            55  O1d O    20.5765  -20.4167 #-
            56  O1d O    19.1905  -18.0164
            57  O2a O    22.2840  -12.2868
            58  S4a S    23.4842  -11.5938
            59  O1d O    24.6846  -10.9008
            60  O1d O    24.4689  -12.5787
            61  O1d O    22.5093  -10.6187 #-
            62  O2a O    41.4818  -12.2908
            63  S4a S    42.6820  -11.5979
            64  O1d O    43.8822  -10.9049
            65  O1d O    41.9874  -10.3949 #-
            66  O1d O    43.3733  -12.7951
            67  S4a S    36.6954  -12.2822
            68  O2a O    31.9089  -12.2737
            69  S4a S    33.1091  -11.5807
            70  O1d O    34.3094  -10.8877
            71  O1d O    32.4247  -10.3947 #-
            72  O1d O    33.8100  -12.7952
            73  O1d O    37.8956  -11.5892 #-
            74  O1d O    35.9942  -11.0673
            75  O1d O    37.3796  -13.4678
            76  S4a S    28.3020  -18.5140
            77  O1d O    28.3020  -19.8999 #-
            78  O1d O    29.6711  -18.5140
            79  O1d O    26.8992  -18.5140
            80  O6a O    36.6954  -19.2019 #-
            81  O6a O    34.2948  -19.2120
            82  O6a O    27.1224  -19.9118
            83  O6a O    24.7219  -19.8879 #-
            84  S4a S    31.9089  -19.5569
            85  S4a S    41.4818  -19.5398
            86  O1d O    33.1091  -20.2499 #-
            87  O1d O    31.2125  -20.7633
            88  O1d O    32.5982  -18.3628
            89  O1d O    42.6820  -20.2328
            90  O1d O    40.7757  -20.7633
            91  O1d O    42.1610  -18.3627 #-
            92  Z   Na   20.5931  -10.6140 #+
            93  Z   Na   22.1177  -20.4543 #+
            94  Z   Na   40.0658  -10.4061 #+
            95  Z   Na   30.3641  -10.4061 #+
            96  Z   Na   37.5711  -10.4754 #+
            97  Z   Na   28.2852  -20.9394 #+
            98  Z   Na   37.6404  -19.9692 #+
            99  Z   Na   24.4738  -20.9394 #+
            100 Z   Na   43.6693  -18.3754 #+
            101 Z   Na   34.5220  -20.5236 #+
BOND        95
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1 #Down
            8     8   7 1 #Up
            9     8   9 1
            10    9  10 1 #Down
            11    8  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  14 1
            16   16  15 1 #Up
            17   16  17 1
            18   17  18 1 #Down
            19   13  18 1 #Down
            20   16  19 1
            21   20  19 1
            22   20  21 1
            23   21  22 1
            24   17  22 1
            25   20  23 1 #Down
            26   24  23 1 #Up
            27   24  25 1
            28   25  26 1 #Down
            29   24  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   25  30 1
            34   32  31 1 #Up
            35   32  33 1
            36   33  34 1 #Down
            37   29  34 1 #Down
            38   32  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   33  38 1
            43    2  39 1 #Up
            44    6  40 1 #Up
            45   14  41 1 #Up
            46   22  42 1 #Up
            47   30  43 1 #Up
            48   38  44 1 #Up
            49    1  45 1 #Down
            50    3  46 1 #Down
            51   11  47 1 #Down
            52   19  48 1 #Down
            53   36  49 1 #Down
            54   35  50 1 #Down
            55   27  51 1 #Up
            56   49  52 1
            57   46  53 1
            58   53  54 2
            59   53  55 1
            60   53  56 2
            61   40  57 1
            62   57  58 1
            63   58  59 2
            64   58  60 2
            65   58  61 1
            66   44  62 1
            67   62  63 1
            68   63  64 2
            69   63  65 1
            70   63  66 2
            71   43  67 1
            72   42  68 1
            73   68  69 1
            74   69  70 2
            75   69  71 1
            76   69  72 2
            77   67  73 1
            78   67  74 2
            79   67  75 2
            80   15  76 1
            81   76  77 1
            82   76  78 2
            83   76  79 2
            84   51  80 1
            85   51  81 2
            86   47  82 2
            87   47  83 1
            88   48  84 1
            89   50  85 1
            90   84  86 1
            91   84  87 2
            92   84  88 2
            93   85  89 2
            94   85  90 2
            95   85  91 1

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