| Entry |
|
|---|
| Name |
Doxapram hydrochloride (USP);
Doxapram hydrochloride hydrate (JP18);
Dopram (TN) |
|---|
| Product |
|
|---|
| Formula |
C24H30N2O2. HCl. H2O
|
|---|
| Exact mass |
432.2180
|
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| Mol weight |
432.98
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02925 CYP3A5 substrate
|
|---|
| Remark |
| Therapeutic category: | 2219 |
| Product (DG01119): | D01872<JP/US> |
|
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| Efficacy |
Respiratory stimulant |
|---|
| Comment |
Doxapram stimulates carotid body.
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R07 OTHER RESPIRATORY SYSTEM PRODUCTS
R07A OTHER RESPIRATORY SYSTEM PRODUCTS
R07AB Respiratory stimulants
R07AB01 Doxapram
D01872 Doxapram hydrochloride (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
221 Respiratory stimulants
2219 Others
D01872 Doxapram hydrochloride (USP); Doxapram hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01119 Doxapram
D01872 Doxapram hydrochloride
DG02925 CYP3A5 substrate
DG01119 Doxapram
D01872 Doxapram hydrochloride
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01872 Doxapram hydrochloride hydrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01872
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01119 Doxapram
DG02925 CYP3A5 substrate
DG01119 Doxapram
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 X Cl 37.8738 -14.8648
2 O0 O 38.2758 -16.4748
3 C8x C 25.4800 -14.9800
4 C8x C 25.4800 -16.3800
5 C8x C 26.6924 -17.0800
6 C8x C 27.9049 -16.3800
7 C8y C 27.9049 -14.9800
8 C8x C 26.6924 -14.2800
9 C8x C 30.3297 -16.3800
10 C8y C 30.3297 -14.9800
11 C1z C 29.1173 -14.2800
12 C8x C 31.5422 -17.0800
13 C8x C 32.7546 -16.3800
14 C8x C 32.7546 -14.9800
15 C8x C 31.5422 -14.2800
16 C1y C 30.2616 -13.4729
17 C1x C 29.8480 -12.1354
18 N1y N 28.4482 -12.1154
19 C5x C 27.9966 -13.4405
20 C1b C 27.6300 -10.9542
21 C1a C 26.2300 -10.9542
22 O5x O 26.5966 -13.4405
23 C1b C 31.6616 -13.4729
24 C1b C 32.3706 -12.2458
25 N1y N 33.7400 -12.2463
26 C1x C 34.4411 -13.4618
27 C1x C 35.8411 -13.4623
28 O2x O 36.5416 -12.2502
29 C1x C 35.8405 -11.0347
30 C1x C 34.4405 -11.0342
BOND 31
1 3 4 2
2 4 5 1
3 5 6 2
4 6 7 1
5 7 8 2
6 3 8 1
7 9 10 1
8 10 11 1
9 7 11 1
10 9 12 2
11 12 13 1
12 13 14 2
13 14 15 1
14 10 15 2
15 11 16 1
16 16 17 1
17 17 18 1
18 18 19 1
19 11 19 1
20 18 20 1
21 20 21 1
22 19 22 2
23 16 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 26 27 1
28 27 28 1
29 28 29 1
30 29 30 1
31 25 30 1
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