KEGG   DRUG: OmapatrilatHelp
Entry
D01970                      Drug                                   

Name
Omapatrilat (JAN/USAN/INN);
BMS 186716
Formula
C19H24N2O4S2
Exact mass
408.1177
Mol weight
408.5349
Structure
Mol fileKCF fileDB search
Efficacy
Antihypertensive, Neprilysin inhibitor
Comment
Treatment of hypertension and congestive heart failure
Target
MME (CD10) [HSA:4311] [KO:K01389]
  Pathway
hsa04614  Renin-angiotensin system
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Metallo peptidases
    MME (CD10)
     D01970  Omapatrilat (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 167305-00-2
PubChem: 7849032
ChEMBL: CHEMBL289556
DrugBank: DB00886
PDB-CCD: FT8[PDBj]
LigandBox: D01970
LinkDB All DBs
KCF data Show

ATOM        27
            1   C1x C    33.2960  -19.1343
            2   C1y C    33.6217  -17.7852
            3   C1x C    34.1799  -20.2507
            4   C5x C    34.8777  -17.1805
            5   S2x S    35.5754  -20.2507
            6   N1y N    36.1337  -17.7852
            7   C1y C    36.4593  -19.1343
            8   C1x C    37.8031  -19.5306
            9   C1x C    38.8182  -18.5649
            10  C1x C    38.4925  -17.2158
            11  C1y C    37.1488  -16.8196
            12  O5x O    34.8748  -15.7799
            13  N1b N    32.5286  -16.9022
            14  C5a C    31.3216  -17.5855
            15  C1c C    30.1239  -16.8752
            16  C1b C    28.9104  -17.5568
            17  C8y C    27.7134  -16.8469
            18  O5a O    31.3050  -18.9988
            19  S1a S    30.1404  -15.4730
            20  C8x C    27.7298  -15.4451
            21  C8x C    26.5249  -14.7305
            22  C8x C    25.3033  -15.4166
            23  C8x C    25.2869  -16.8185
            24  C8x C    26.4920  -17.5332
            25  C6a C    37.1488  -15.4196
            26  O6a O    38.3857  -14.7056
            27  O6a O    35.9441  -14.7238
BOND        29
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     5   7 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    6  11 1
            13    4  12 2
            14    2  13 1 #Down
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   14  18 2
            20   15  19 1 #Down
            21   17  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   17  24 1
            27   11  25 1 #Down
            28   25  26 1
            29   25  27 2

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