Homo sapiens (human): 4311
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Entry
4311 CDS
T01001
Symbol
MME, CALLA, CD10, CMT2T, NEP, SCA43, SFE
Name
(RefSeq) membrane metalloendopeptidase
KO
K01389
neprilysin [EC:
3.4.24.11
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04614
Renin-angiotensin system
hsa04640
Hematopoietic cell lineage
hsa04974
Protein digestion and absorption
hsa05010
Alzheimer disease
Network
nt06460
Alzheimer disease
Element
N01415
NEP-mediated Abeta degradation
N01416
Mercury to NEP-mediated Abeta degradation
Disease
H00063
Spinocerebellar ataxia (SCA)
H00264
Charcot-Marie-Tooth disease
Drug target
Candoxatril:
D01070
Candoxatrilat:
D03349
Ecadotril:
D03929
Omapatrilat:
D01970
Racecadotril:
D08464
Sacubitril:
D10225
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
4311 (MME)
09152 Endocrine system
04614 Renin-angiotensin system
4311 (MME)
09154 Digestive system
04974 Protein digestion and absorption
4311 (MME)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
4311 (MME)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
4311 (MME)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
4311 (MME)
04090 CD molecules [BR:
hsa04090
]
4311 (MME)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.11 neprilysin
4311 (MME)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M13: neprilysin family
4311 (MME)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
4311 (MME)
CD molecules [BR:
hsa04090
]
Proteins
4311 (MME)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_M13_N
Peptidase_M13
Motif
Other DBs
NCBI-GeneID:
4311
NCBI-ProteinID:
NP_000893
OMIM:
120520
HGNC:
7154
Ensembl:
ENSG00000196549
Vega:
OTTHUMG00000158455
Pharos:
P08473
(Tclin)
UniProt:
P08473
Structure
PDB
LinkDB
All DBs
Position
3:155024202..155183729
Genome browser
AA seq
750 aa
AA seq
DB search
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
NT seq
2253 nt
NT seq
+upstream
nt +downstream
nt
atgggcaagtcagaaagtcagatggatataactgatatcaacactccaaagccaaagaag
aaacagcgatggactccactggagatcagcctctcggtccttgtcctgctcctcaccatc
atagctgtgacaatgatcgcactctatgcaacctacgatgatggtatttgcaagtcatca
gactgcataaaatcagctgctcgactgatccaaaacatggatgccaccactgagccttgt
acagactttttcaaatatgcttgcggaggctggttgaaacgtaatgtcattcccgagacc
agctcccgttacggcaactttgacattttaagagatgaactagaagtcgttttgaaagat
gtccttcaagaacccaaaactgaagatatagtagcagtgcagaaagcaaaagcattgtac
aggtcttgtataaatgaatctgctattgatagcagaggtggagaacctctactcaaactg
ttaccagacatatatgggtggccagtagcaacagaaaactgggagcaaaaatatggtgct
tcttggacagctgaaaaagctattgcacaactgaattctaaatatgggaaaaaagtcctt
attaatttgtttgttggcactgatgataagaattctgtgaatcatgtaattcatattgac
caacctcgacttggcctcccttctagagattactatgaatgcactggaatctataaagag
gcttgtacagcatatgtggattttatgatttctgtggccagattgattcgtcaggaagaa
agattgcccatcgatgaaaaccagcttgctttggaaatgaataaagttatggaattggaa
aaagaaattgccaatgctacggctaaacctgaagatcgaaatgatccaatgcttctgtat
aacaagatgacattggcccagatccaaaataacttttcactagagatcaatgggaagcca
ttcagctggttgaatttcacaaatgaaatcatgtcaactgtgaatattagtattacaaat
gaggaagatgtggttgtttatgctccagaatatttaaccaaacttaagcccattcttacc
aaatattctgccagagatcttcaaaatttaatgtcctggagattcataatggatcttgta
agcagcctcagccgaacctacaaggagtccagaaatgctttccgcaaggccctttatggt
acaacctcagaaacagcaacttggagacgttgtgcaaactatgtcaatgggaatatggaa
aatgctgtggggaggctttatgtggaagcagcatttgctggagagagtaaacatgtggtc
gaggatttgattgcacagatccgagaagtttttattcagactttagatgacctcacttgg
atggatgccgagacaaaaaagagagctgaagaaaaggccttagcaattaaagaaaggatc
ggctatcctgatgacattgtttcaaatgataacaaactgaataatgagtacctcgagttg
aactacaaagaagatgaatacttcgagaacataattcaaaatttgaaattcagccaaagt
aaacaactgaagaagctccgagaaaaggtggacaaagatgagtggataagtggagcagct
gtagtcaatgcattttactcttcaggaagaaatcagatagtcttcccagccggcattctg
cagccccccttctttagtgcccagcagtccaactcattgaactatgggggcatcggcatg
gtcataggacacgaaatcacccatggcttcgatgacaatggcagaaactttaacaaagat
ggagacctcgttgactggtggactcaacagtctgcaagtaactttaaggagcaatcccag
tgcatggtgtatcagtatggaaacttttcctgggacctggcaggtggacagcaccttaat
ggaattaatacactgggagaaaacattgctgataatggaggtcttggtcaagcatacaga
gcctatcagaattatattaaaaagaatggcgaagaaaaattacttcctggacttgaccta
aatcacaaacaactatttttcttgaactttgcacaggtgtggtgtggaacctataggcca
gagtatgcggttaactccattaaaacagatgtgcacagtccaggcaatttcaggattatt
gggactttgcagaactctgcagagttttcagaagcctttcactgccgcaagaattcatac
atgaatccagaaaagaagtgccgggtttggtga
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