Homo sapiens (human): 4311 Help Entry 4311              CDS       T01001                                  Symbol MME, CALLA, CD10, CMT2T, NEP, SCA43, SFE Name (RefSeq) membrane metalloendopeptidase   KO K01389   neprilysin [EC:3.4.24.11] Organism hsa  Homo sapiens (human) Pathway hsa04614   Renin-angiotensin system hsa04640   Hematopoietic cell lineage hsa04974   Protein digestion and absorption hsa05010   Alzheimer disease Network nt06460  Alzheimer disease   Element N01415   NEP-mediated Abeta degradation N01416   Mercury to NEP-mediated Abeta degradation Disease H00063   Spinocerebellar ataxia (SCA) H00264   Charcot-Marie-Tooth disease Drug target Candoxatril:  D01070 Candoxatrilat:  D03349 Ecadotril:  D03929 Omapatrilat:  D01970 Racecadotril:  D08464 Sacubitril:  D10225 Valsartan and sacubitril:  D10226<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     4311 (MME)   09152 Endocrine system    04614 Renin-angiotensin system     4311 (MME)   09154 Digestive system    04974 Protein digestion and absorption     4311 (MME)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     4311 (MME)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     4311 (MME)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     4311 (MME)    04090 CD molecules [BR:hsa04090]     4311 (MME) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.24  Metalloendopeptidases     3.4.24.11  neprilysin      4311 (MME) Peptidases and inhibitors [BR:hsa01002]  Metallo peptidases   Family M13: neprilysin family    4311 (MME) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    4311 (MME) CD molecules [BR:hsa04090]  Proteins   4311 (MME) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_M13_N Peptidase_M13 M157_N_1 PEX14-like_2nd Motif Other DBs NCBI-GeneID:  4311 NCBI-ProteinID:  NP_000893 OMIM:  120520 HGNC:  7154 Ensembl:  ENSG00000196549 UniProt:  P08473 Structure PDBPDBj LinkDB All DBs Position 3:155024202..155183729 Genome browser AA seq 750 aa AA seqDB search MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW NT seq 2253 nt NT seq  +upstreamnt  +downstreamnt atgggcaagtcagaaagtcagatggatataactgatatcaacactccaaagccaaagaag aaacagcgatggactccactggagatcagcctctcggtccttgtcctgctcctcaccatc atagctgtgacaatgatcgcactctatgcaacctacgatgatggtatttgcaagtcatca gactgcataaaatcagctgctcgactgatccaaaacatggatgccaccactgagccttgt acagactttttcaaatatgcttgcggaggctggttgaaacgtaatgtcattcccgagacc agctcccgttacggcaactttgacattttaagagatgaactagaagtcgttttgaaagat gtccttcaagaacccaaaactgaagatatagtagcagtgcagaaagcaaaagcattgtac aggtcttgtataaatgaatctgctattgatagcagaggtggagaacctctactcaaactg ttaccagacatatatgggtggccagtagcaacagaaaactgggagcaaaaatatggtgct tcttggacagctgaaaaagctattgcacaactgaattctaaatatgggaaaaaagtcctt attaatttgtttgttggcactgatgataagaattctgtgaatcatgtaattcatattgac caacctcgacttggcctcccttctagagattactatgaatgcactggaatctataaagag gcttgtacagcatatgtggattttatgatttctgtggccagattgattcgtcaggaagaa agattgcccatcgatgaaaaccagcttgctttggaaatgaataaagttatggaattggaa aaagaaattgccaatgctacggctaaacctgaagatcgaaatgatccaatgcttctgtat aacaagatgacattggcccagatccaaaataacttttcactagagatcaatgggaagcca ttcagctggttgaatttcacaaatgaaatcatgtcaactgtgaatattagtattacaaat gaggaagatgtggttgtttatgctccagaatatttaaccaaacttaagcccattcttacc aaatattctgccagagatcttcaaaatttaatgtcctggagattcataatggatcttgta agcagcctcagccgaacctacaaggagtccagaaatgctttccgcaaggccctttatggt acaacctcagaaacagcaacttggagacgttgtgcaaactatgtcaatgggaatatggaa aatgctgtggggaggctttatgtggaagcagcatttgctggagagagtaaacatgtggtc gaggatttgattgcacagatccgagaagtttttattcagactttagatgacctcacttgg atggatgccgagacaaaaaagagagctgaagaaaaggccttagcaattaaagaaaggatc ggctatcctgatgacattgtttcaaatgataacaaactgaataatgagtacctcgagttg aactacaaagaagatgaatacttcgagaacataattcaaaatttgaaattcagccaaagt aaacaactgaagaagctccgagaaaaggtggacaaagatgagtggataagtggagcagct gtagtcaatgcattttactcttcaggaagaaatcagatagtcttcccagccggcattctg cagccccccttctttagtgcccagcagtccaactcattgaactatgggggcatcggcatg gtcataggacacgaaatcacccatggcttcgatgacaatggcagaaactttaacaaagat ggagacctcgttgactggtggactcaacagtctgcaagtaactttaaggagcaatcccag tgcatggtgtatcagtatggaaacttttcctgggacctggcaggtggacagcaccttaat ggaattaatacactgggagaaaacattgctgataatggaggtcttggtcaagcatacaga gcctatcagaattatattaaaaagaatggcgaagaaaaattacttcctggacttgaccta aatcacaaacaactatttttcttgaactttgcacaggtgtggtgtggaacctataggcca gagtatgcggttaactccattaaaacagatgtgcacagtccaggcaatttcaggattatt gggactttgcagaactctgcagagttttcagaagcctttcactgccgcaagaattcatac atgaatccagaaaagaagtgccgggtttggtga

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