KEGG   DRUG: LuliconazoleHelp
Entry
D01980                      Drug                                   

Name
Luliconazole (JAN/USAN/INN);
Lulicon (TN);
Luzu (TN)
Product
Formula
C14H9Cl2N3S2
Exact mass
352.9615
Mol weight
354.2774
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antifungal
 DG01883  Imidazole antifungal
Metabolizing enzyme inhibitor
 DG02892  CYP2B6 inhibitor
 DG01641  CYP2C8 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: C13478
Therapeutic category: 2655 6290
ATC code: D01AC18
Product: D01980<JP/US>
Efficacy
Antifungal
Comment
Imidazole derivative
Treatment of fungal infections
Target
sterol 14alpha-demethylase [KO:K05917]
Interaction
CYP inhibition: CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC18 Luliconazole
      D01980  Luliconazole (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antifungals
  Luliconazole
   D01980  Luliconazole (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2655  Imidazoles
     D01980  Luliconazole (JAN/USAN/INN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D01980  Luliconazole (JAN/USAN/INN)
Antiinfectives [br08350.html]
 Antifungals
  D01980
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01980
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01980
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01980
BRITE hierarchy
Other DBs
CAS: 187164-19-8
PubChem: 7849042
ChEBI: 34825
ChEMBL: CHEMBL2105689
LigandBox: D01980
NIKKAJI: J937.034J
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8x C    28.1477  -19.2608
            2   C8y C    28.1477  -20.7024
            3   C8x C    29.3567  -21.3535
            4   C8y C    30.5658  -20.6559
            5   C8y C    30.5658  -19.2608
            6   C8x C    29.3567  -18.5633
            7   X   Cl   31.7750  -21.3535
            8   C1y C    31.7750  -18.5633
            9   S2x S    33.1236  -18.5633
            10  C2y C    33.5887  -17.2146
            11  S2x S    32.4726  -16.4240
            12  C1x C    31.3100  -17.2146
            13  C2c C    34.7977  -16.5170
            14  X   Cl   26.9386  -21.4000
            15  C3b C    36.0281  -17.2277
            16  N4y N    34.7983  -15.1402
            17  C8x C    35.9389  -14.3121
            18  N5x N    35.5038  -12.9715
            19  C8x C    34.0944  -12.9710
            20  C8x C    33.6584  -14.3113
            21  N3a N    37.2352  -17.9343
BOND        23
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     4   7 1
            5     8   5 1 #Down
            6     5   6 2
            7     6   1 1
            8     1   2 2
            9    11  12 1
            10   12   8 1
            11    8   9 1
            12   13  10 2
            13    9  10 1
            14   10  11 1
            15    2  14 1
            16   13  15 1
            17   13  16 1
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   16  20 1
            23   15  21 3

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