| Entry |
|
|---|
| Name |
Tadalafil (JAN/USAN/INN);
Adcirca (TN);
Cialis (TN);
Zalutia (TN)
|
|---|
| Product |
CIALIS (Aphena Pharma Solutions - Tennessee), ADCIRCA (Aphena Pharma Solutions - Tennessee), CIALIS (Aphena Pharma Solutions - Tennessee), CIALIS (Bryant Ranch Prepack), CIALIS (Bryant Ranch Prepack), CIALIS (Bryant Ranch Prepack), CIALIS (Cardinal Health), CIALIS (Dispensing Solutions), CIALIS (Eli Lilly and Company), CIALIS (PD-Rx Pharmaceuticals), CIALIS (Rebel Distributors Corp.), ADCIRCA (United Therapeutics Corporation) |
|---|
| Generic |
|
|---|
| Formula |
C22H19N3O4
|
|---|
| Exact mass |
389.1376
|
|---|
| Mol weight |
389.404
|
|---|
| Structure |
   |
|---|
| Class |
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
Enzyme substrate
DG01633 CYP3A substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Impotence therapy, Phosphodiesterase V inhibitor |
|---|
| Disease |
Pulmonary arterial hypertension [DS: H01621] |
|---|
| Comment |
Treatment of male erectile and female sexual dysfunction
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE08 Tadalafil
D02008 Tadalafil (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Genitourinary Agents
Benign Prostatic Hypertrophy Agents
Tadalafil
D02008 Tadalafil (JAN/USAN/INN)
Respiratory Tract/Pulmonary Agents
Pulmonary Antihypertensives
Tadalafil
D02008 Tadalafil (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D02008 Tadalafil (JAN/USAN/INN)
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D02008 Tadalafil (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Phosphodiesterase
PDE5
D02008 Tadalafil (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
Endocrine and hormonal agents
D02008
New drug approvals in the USA [br08319.html]
New Molecular Entity and New Therapeutic Biological Product Approvals
D02008
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02008
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02008
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02008
 |
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| Other DBs |
|
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| LinkDB |
 |
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| KCF data |
ATOM 29
1 N1y N 29.4582 -12.6733
2 C1x C 30.1741 -13.7777
3 C5x C 29.5963 -15.0632
4 N1y N 28.2326 -15.0448
5 C1y C 27.4708 -14.1585
6 C5x C 28.0566 -12.6389
7 C1y C 27.6549 -16.4236
8 C8y C 26.2912 -16.4518
9 C1x C 26.1152 -14.1159
10 C8y C 25.5294 -15.3555
11 O5x O 27.2788 -11.5908
12 O5x O 30.4201 -16.2432
13 C8y C 28.4706 -17.5343
14 C8x C 29.8722 -17.4755
15 C8x C 30.6960 -18.6089
16 C8y C 30.0724 -19.9725
17 C8y C 28.6250 -19.9694
18 C8x C 27.8471 -18.8281
19 O2x O 30.5829 -21.1851
20 C1x C 29.5192 -22.1306
21 O2x O 28.3012 -21.3988
22 C1a C 30.0900 -11.4256
23 C8y C 24.1928 -15.8284
24 C8y C 24.2058 -17.2380
25 N4x N 25.5595 -17.6699
26 C8x C 22.9827 -15.1426
27 C8x C 21.7866 -15.8747
28 C8x C 21.8003 -17.2924
29 C8x C 23.0561 -17.9701
BOND 34
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 5 9 1
10 10 8 2
11 9 10 1
12 6 11 2
13 3 12 2
14 7 13 1 #Down
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 16 19 1
22 19 20 1
23 20 21 1
24 17 21 1
25 1 22 1
26 10 23 1
27 23 24 1
28 24 25 1
29 25 8 1
30 23 26 2
31 26 27 1
32 27 28 2
33 28 29 1
34 24 29 2
|
|---|
