KEGG   DRUG: Oleandomycin phosphate
Entry
D02186                      Drug                                   
Name
Oleandomycin phosphate (JAN);
Matromycin (TN)
Formula
C35H61NO12. H3PO4
Exact mass
785.3963
Mol weight
785.85
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Remark
ATC code: J01FA05
Chemical structure group: DG00603
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA05 Oleandomycin
      D02186  Oleandomycin phosphate (JAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00603  Oleandomycin
     D02186  Oleandomycin phosphate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02186  Oleandomycin phosphate (JAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00603  Oleandomycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00603  Oleandomycin
Other DBs
CAS: 7060-74-4
PubChem: 7849246
LigandBox: D02186
NIKKAJI: J231.526B
LinkDB
KCF data

ATOM        53
            1   C1z C    19.6948  -12.4878
            2   C1x C    19.6948  -11.0425
            3   O2x O    20.9070  -11.7884
            4   C1x C    19.6948  -13.8864
            5   C5x C    18.4827  -11.7884
            6   C1y C    20.9070  -14.5857
            7   C1y C    17.2705  -12.4878
            8   O5x O    18.4827  -10.3898
            9   C1y C    20.9070  -15.9843
            10  C1a C    22.1191  -13.8864
            11  C1y C    17.2705  -13.8864
            12  C1a C    16.0584  -11.7884
            13  C1y C    19.6948  -16.6837
            14  O2a O    22.1191  -16.6837
            15  C1y C    16.0584  -14.5857
            16  O1a O    18.4827  -14.5857
            17  C1y C    19.6948  -18.0823
            18  C1a C    18.8327  -15.6343
            19  C1y C    23.5178  -16.6370
            20  C1y C    16.0584  -15.9843
            21  C1a C    14.8463  -13.8864
            22  O2a O    20.9070  -18.7816
            23  C1y C    18.4827  -18.7816
            24  C1y C    24.2171  -15.4249
            25  O2x O    24.2637  -17.8492
            26  O7x O    17.2705  -16.6837
            27  C1a C    14.8463  -16.6837
            28  C1y C    22.1191  -19.4809
            29  C7x C    17.2705  -18.0823
            30  C1a C    18.4827  -20.1802
            31  C1y C    25.6156  -15.4249
            32  O1a O    23.4711  -14.2127
            33  C1y C    25.6156  -17.8726
            34  C1x C    22.1191  -20.8795
            35  O2x O    23.3313  -18.7816
            36  O6a O    16.0584  -18.7816
            37  C1x C    26.3149  -16.5904
            38  N1c N    26.2683  -14.1661
            39  C1a C    27.0142  -18.2688
            40  C1y C    23.3313  -21.5322
            41  C1y C    24.5434  -19.4809
            42  C1a C    25.5225  -13.0006
            43  C1a C    27.6669  -14.1661
            44  C1y C    24.5434  -20.8795
            45  O2a O    23.3313  -22.9309
            46  C1a C    25.7555  -18.7816
            47  O1a O    25.7555  -21.5322
            48  C1a C    22.1191  -23.6302
            49  P1b P    31.0332  -21.1167
            50  O1c O    31.0332  -19.7167
            51  O1c O    32.4332  -21.1167
            52  O1c O    29.6332  -21.1167
            53  O1c O    31.0332  -22.5167
BOND        55
            1     1   2 1
            2     1   3 1 #Up
            3     1   4 1
            4     1   5 1
            5     4   6 1
            6     5   7 1
            7     5   8 2
            8     6   9 1
            9     6  10 1 #Down
            10    7  11 1
            11    7  12 1 #Up
            12    9  13 1
            13    9  14 1 #Down
            14   11  15 1
            15   11  16 1 #Up
            16   13  17 1
            17   13  18 1 #Down
            18   19  14 1 #Up
            19   15  20 1
            20   15  21 1 #Down
            21   17  22 1 #Down
            22   17  23 1
            23   19  24 1
            24   19  25 1
            25   20  26 1
            26   20  27 1 #Down
            27   28  22 1 #Down
            28   23  29 1
            29   23  30 1 #Up
            30   24  31 1
            31   24  32 1 #Down
            32   25  33 1
            33   28  34 1
            34   28  35 1
            35   29  36 2
            36   31  37 1
            37   31  38 1 #Up
            38   33  39 1 #Up
            39   34  40 1
            40   35  41 1
            41   38  42 1
            42   38  43 1
            43   40  44 1
            44   40  45 1 #Up
            45   41  46 1 #Up
            46   44  47 1 #Down
            47   45  48 1
            48    2   3 1
            49   26  29 1
            50   33  37 1
            51   41  44 1
            52   49  50 2
            53   49  51 1
            54   49  52 1
            55   49  53 1

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KEGG   DRUG: Troleandomycin
Entry
D01322                      Drug                                   
Name
Troleandomycin (USAN/INN);
Triacetyloleandomycin (JAN);
TAO;
Tao (TN)
Formula
C41H67NO15
Exact mass
813.4511
Mol weight
813.97
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Remark
Same as: C12753
ATC code: J01FA08
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA08 Troleandomycin
      D01322  Troleandomycin (USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    D01322  Troleandomycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01322  Troleandomycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    D01322  Troleandomycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D01322  Troleandomycin (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01322
Other DBs
CAS: 2751-09-9
PubChem: 7848385
ChEBI: 45735
LigandBox: D01322
NIKKAJI: J7.904I
LinkDB
KCF data

ATOM        57
            1   C1z C    21.0419  -12.6310
            2   C1x C    21.1002  -11.2073
            3   O2x O    22.3239  -11.9250
            4   C1x C    21.0419  -14.0309
            5   C5x C    19.8302  -11.9250
            6   C1y C    22.2597  -14.7193
            7   C1y C    18.6242  -12.6310
            8   O5x O    19.8302  -10.5367
            9   C1y C    22.2597  -16.1194
            10  C1a C    23.4598  -14.0251
            11  C1y C    18.6242  -14.0309
            12  C1a C    17.4123  -11.9250
            13  C1y C    21.0419  -16.8193
            14  O2a O    23.7339  -17.0293
            15  C1y C    17.4123  -14.7193
            16  C1y C    21.0419  -18.2136
            17  C1a C    19.8302  -16.1194
            18  C1y C    25.8399  -16.7900
            19  C1y C    17.4123  -16.1194
            20  C1a C    16.2065  -14.0251
            21  O2a O    22.2597  -18.9078
            22  C1y C    19.8302  -18.9078
            23  C1y C    26.5164  -15.5723
            24  O2x O    26.5576  -17.9842
            25  O7x O    18.6242  -16.8193
            26  C1a C    16.2005  -16.8253
            27  C1y C    22.3456  -20.5820
            28  C7x C    18.6242  -18.2136
            29  C1a C    19.8302  -20.3019
            30  C1y C    27.9107  -15.5487
            31  O7a O    25.7869  -14.3663
            32  C1y C    27.9458  -17.9606
            33  C1x C    22.3456  -21.9879
            34  O2x O    23.5516  -19.8878
            35  O6a O    17.4123  -18.9078
            36  C1x C    28.6224  -16.7429
            37  N1c N    28.5871  -14.3310
            38  C1y C    23.5516  -22.6762
            39  C1y C    24.7576  -20.5820
            40  C1a C    29.9754  -14.3774
            41  C1y C    24.7576  -21.9879
            42  O2a O    23.5576  -24.0704
            43  C1a C    25.9635  -19.8878
            44  O7a O    25.9635  -22.6762
            45  C1a C    22.3516  -24.7703
            46  C7a C    25.7792  -12.9563
            47  C1a C    26.9940  -12.2459
            48  O6a O    24.5564  -12.2594
            49  O7a O    16.6995  -12.9760
            50  C7a C    15.4768  -12.2723
            51  O6a O    15.4749  -10.8648
            52  C1a C    14.2589  -12.9775
            53  C7a C    27.1790  -21.9665
            54  C1a C    28.4014  -22.6641
            55  O6a O    27.1720  -20.5591
            56  C1a C    28.5871  -12.9310
            57  C1a C    28.6749  -19.1754
BOND        60
            1     7  11 1
            2     7  12 1 #Up
            3     9  13 1
            4     9  14 1 #Down
            5    11  15 1
            6    13  16 1
            7    13  17 1 #Down
            8    18  14 1 #Up
            9    15  19 1
            10   15  20 1 #Down
            11   16  21 1 #Down
            12   16  22 1
            13   18  23 1
            14   18  24 1
            15   19  25 1
            16   19  26 1 #Down
            17   27  21 1 #Down
            18   22  28 1
            19   22  29 1 #Up
            20   23  30 1
            21   23  31 1 #Down
            22   24  32 1
            23   27  33 1
            24   27  34 1
            25   28  35 2
            26   30  36 1
            27   30  37 1 #Up
            28   33  38 1
            29   34  39 1
            30   37  40 1
            31   38  41 1
            32   38  42 1 #Up
            33   39  43 1 #Up
            34   41  44 1 #Down
            35   42  45 1
            36    2   3 1
            37   25  28 1
            38   32  36 1
            39   39  41 1
            40   31  46 1
            41    1   2 1
            42   46  47 1
            43    1   3 1 #Up
            44   46  48 2
            45    1   4 1
            46   11  49 1 #Up
            47    1   5 1
            48   49  50 1
            49    4   6 1
            50   50  51 2
            51    5   7 1
            52   50  52 1
            53    5   8 2
            54   44  53 1
            55    6   9 1
            56   53  54 1
            57    6  10 1 #Down
            58   53  55 2
            59   37  56 1
            60   32  57 1 #Up

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