KEGG   DRUG: Clocortolone pivalateHelp
Entry
D02287                      Drug                                   

Name
Clocortolone pivalate (USP);
Cloderm (TN)
Product
  Generic
Formula
C27H36ClFO5
Exact mass
494.2235
Mol weight
495.0231
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: D07AB21
Chemical structure group: DG00416
Product (DG00416): D02287<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Comment
Prednisolone [DR:D00427] derivative
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB21 Clocortolone
      D02287  Clocortolone pivalate (USP) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Clocortolone
   D02287  Clocortolone pivalate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02287  Clocortolone pivalate (USP) <US>
BRITE hierarchy
Other DBs
CAS: 34097-16-0
PubChem: 7849346
ChEBI: 59583
ChEMBL: CHEMBL1200975
DrugBank: DB00838
LigandBox: D02287
NIKKAJI: J28.616H
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C    12.6685  -17.5689
            2   C5x C    12.6685  -18.9302
            3   C2x C    13.8474  -19.6110
            4   C2y C    15.0263  -18.9302
            5   C1z C    15.0263  -17.5689
            6   C2x C    13.8474  -16.8882
            7   C1y C    16.2054  -19.6110
            8   C1x C    17.3843  -18.9302
            9   C1y C    17.3843  -17.5689
            10  C1z C    16.2054  -16.8882
            11  C1y C    18.5632  -16.8882
            12  C1z C    18.5632  -15.5269
            13  C1x C    17.3843  -14.8462
            14  C1y C    16.2054  -15.5269
            15  C1x C    20.9212  -16.8882
            16  C1y C    20.9212  -15.5269
            17  C1y C    19.7422  -14.8462
            18  X   F    16.2079  -20.9723
            19  X   Cl   16.2079  -18.2496
            20  C1a C    22.1048  -14.8436
            21  C1a C    18.5008  -14.1656
            22  C1a C    15.0281  -16.2076
            23  O5x O    11.4895  -19.6110
            24  O1a O    15.0284  -14.8474
            25  C5a C    19.7419  -13.4412
            26  O5a O    18.4903  -12.7187
            27  C1b C    20.9567  -12.7394
            28  O7a O    22.1639  -13.4361
            29  C7a C    23.3755  -12.7361
            30  C1d C    24.5857  -13.4344
            31  O6a O    23.3753  -11.3052
            32  C1a C    25.7957  -12.7352
            33  C1a C    23.5787  -14.4413
            34  C1a C    25.5925  -14.4413
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    7  18 1 #Down
            22   10  19 1 #Down
            23   16  20 1 #Down
            24   12  21 1 #Up
            25    5  22 1 #Up
            26    2  23 2
            27   14  24 1 #Up
            28   17  25 1 #Up
            29   25  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 1
            36   30  33 1
            37   30  34 1

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